Samir Kelada, PhD

Research Education Contact

Samir Kelada, PhD

Research Focus

Broadly speaking, the Kelada Lab is interested in identifying the combination of genetic and environmental risk factors that leads to asthma. We are specifically focused on identifying genetic variants that affect responses to inhaled allergens, such as house dust mite (HDM) allergen. To identify these interactions, we study both human populations and mouse models of asthma, and we leverage genetic, genomic, and bioinformatic approaches.

There is some overlap in the pathophysiology of asthma and cystic fibrosis. Mucous hyper-secretion is one of these shared features, and we work with CF center faculty to understand what genes control mucous production and secretion. Likewise, we work with investigators in the Center for Airways Disease (headed by Dr. Claire Doerschuk) to understand the molecular mechanisms of asthma that are shared with other airway diseases such as chronic obstructive pulmonary disease.

We are part of the Department of Genetics, the Carolina Center for Genome Sciences, and are located in the Genetic Medicine Building.


1997 B.S. Biochemistry,
University of Michigan, Ann Arbor, MI
2000 M.P.H. Environmental Health,
University of Michigan, Ann Arbor, MI
2006 Ph.D. Toxicology,
University of Washington, Seattle
2006-2012 Post-doctoral fellowship Genetics/Genomics,
National Human Genome Research Institute, National Institutes of Health, Bethesda, MD

Contact Information

5072 Genetic Medicine Bldg.
The University of North Carolina at Chapel Hill
Chapel Hill, NC 27599-7264
Campus Box #7264
Phone: (919) 926-2148