Maimoona Zariwala, PhD

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Maimoona
Maimoona Zariwala, PhD, Research Assistant Professor of Pathology

Research Focus

Dr. Maimoona Zariwala has worked over the past decade to define the genetic basis of ciliopathies, with a focus on Primary Ciliary Dyskinesia (PCD). She is co-Investigator on two grants related to ciliary diseases, and recently had a proposal accepted by the NHLBI/NIH Exome.

Biographical Sketch

Education

(1984) St. Xavier’s College, Univ. of Bombay, India B.Sc., Biochemistry.
(1986) Institute of Science, Univ. of Bombay, India M.Sc., Biochemistry.
(1990) Cancer Research Institute, Tata Memorial Ctr., Ph.D., Biochemistry, University of Bombay, Mumbai, India.
(2002) University of North Carolina at Chapel Hill, NC ABMG Certified Clinical Molecular Genetics.

Professional Experience

(1/2007-Present) Adjunct Faculty, Clinical Molecular Path. Lab., Dept. of Pathology & Lab. Medicine, The University of North Carolina at Chapel Hill
(4/2003-Present) Research Assistant Professor, Department of Pathology and Laboratory Medicine, The University of North Carolina at Chapel Hill
(7/1999-6/2002) Clinical Molecular Genetics Fellow, Dept. of Pathology, UNC-CH, Dr. L. Silverman.
(9/1994-9/1998) Post-doctoral Fellow, UNC-CH, Dr. Yue Xiong. Studies of a novel member of the cyclin E subfamily and mutation detection of the p16 (INK4) gene family.
(9/1994-3/2003) Research Associate (03/2001-3/2003) and Post-doctoral Fellow (9/1998-02/2001) at UNC-CH, Dr. M Knowles. Project involved genetic causes of Primary Ciliary Dyskinesia.
(2/1994-9/1994) Research Associate at Oklahoma State Univ., Stillwater, Dr. G. Ostrander. Project involved studies of molecular aspects of Rb tumor suppressor gene in fish.
(5/1991-12/1993) Post-doctoral Fellow at the Institute of Neuropathology, University Hospital, Zurich with Prof. Paul Kleihues. This project involved the analysis of the p53 tumor suppressor gene.
(11/1986-11/1990) Doctoral student, Cancer Res. Inst., Univ. of Bombay, Dr. S.V. Bhide, and is related to tobacco related carcinogens. Title Ph.D. Thesis: Modulatory Factors of Chemical Carcinogenesis.

Honors and Awards

(1984-1986) Daxina Merit Scholarship, Institute of Science, Mumbai, India.
(1986-1990) Junior/Senior Research Fellowship, Cancer Research Institute, India.

Publications

Please see Pubmed feed in the righthand column for links to current publications.

Research Project Support

Ongoing Projects

9 U54 HL096458-06 (Knowles) 8/1/04-7/31/2014 NIH/NHLBI  Role: Co-Investigator
Genetic Disorders of Mucociliary Clearance
The major goal of this project is to establish a network of geographically-dispersed clinical research sites that
are designed to study rare diseases of the airways, including primary ciliary dyskinesia (PCD).

5 R01 HL071798-06 (Knowles) 1/1/05-12/31/2013 NIH/NHLBI Role: Co-Investigator
Pathogenesis of PCD Lung Disease
The major goals of this project are to define the ciliary physiologic phenotype of PCD, and investigate the
molecular, pathogenesis of lung disease associated with defective MCC.

NHLBI/NHGRI (Nickerson/Shendure) 1/7/2010, Role: Principal Investigator
Whole Exome-Project
Whole exome analysis will be performed on samples from 24 UNC subjects with primary ciliary dyskinesia
(PCD / Kartagener syndrome. There is no salary support but the analysis expense is equivalent to $200,000.

Completed Projects

U54 154 RR019480-05 (Knowles) 8/6/04-7/31/09 NIH/ORD/NCRR Role: Co-Investigator
Genetic Disorders of Mucociliary Clearance
The major goal of this project is to establish a network of geographically-dispersed clinical research sites that
are designed to study rare diseases of the airways.

CETT NIH/ORD 9/1/06-8/31/07 Role: Principal Investigator
Development of clinical genetic test for primary ciliary dyskinesia
The major goal of this project is to transfer the research based genetic tests for primary ciliary dyskinesia to the CLIA approved lab.

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Contact Information

7123 Thurston-Bowles Bldg.
The University of North Carolina at Chapel Hill
Campus Box #7248
Chapel Hill, NC 27599
Phone: (919) 966-7050
Phone: (919) 966-7065
Fax: (919) 966-7524
Email: 
maimoona_zariwala@med.unc.edu

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