John Sheridan is a graduate student in the laboratory of Dr. Robert Tarran.
My work focuses on the Ca2+ sensing protein, STIM1, and the Ca2+-activated Cl- channel (CaCC). Upon endoplasmic reticulum Ca2+ depletion, STIM1 can induce the influx of Ca2+ by activating the Ca2+ release-activated Ca2+ (CRAC) channel. This process has been studies in various cell types, but how STIM1 functions in polarized airway epithelial cells is not fully understood. The influx of Ca2+ is an important step in activation of CaCC, which acts as an alternative Cl- channel from CFTR and helps regulate the airway surface liquid. Recently, Ano1 has been identified as an essential subunit of CaCC, but little is known about the oligomeric structure of CaCC. Determining CaCC subunit assembly is an important first step to better understand how the channel functions and in the development of therapeutically beneficial drugs.
Contact Information7125 Thurston-Bowles Bldg.
The University of North Carolina at Chapel Hill
Campus Box #7248
Chapel Hill, NC 27599
Phone: (919) 966-7053