Yogesh Saini, PhD

Saini2
Yogesh Saini, PhD, Postdoctoral Research Associate

Yogesh Saini, DVM, MVS, PhD, is a Postdoctoral Research Associate in the laboratory of Dr. Richard C Boucher.

Research Focus

  1. The role of macrophages in the pathophysiology of muco-obstructive airway diseases.
  2. Communication between airway epithelia and pulmonary macrophages.

Biographical Sketch

Education

(2009) Dual-PhD Genetics and Environmental Toxicology. Michigan State University, East Lansing, MI. Thesis title: “The role of hypoxia inducible factors in lung development and cobalt-induced lung injury.”

(2003) Master of Veterinary Science (MVSc), With Honors, Animal Biochemistry (Major) with Animal Biotechnology (Minor), G. B. Pant University, Pantnagar, U.P. 263145, India. Master’s Dissertation title: “Standardization of immunological tests for pregnancy diagnosis in mares."

(2001) Doctor of Veterinary Medicine (DVM), Himachal Pradesh Agricultural University, Palampur, HP, India.

Research Experience

(07/10-Present) Postdoctoral Res. Associate, University of North Carolina, NC.
(03/10-06/10) Postdoctoral Res. Associate, Washington University in St. Louis, MO.
(12/09- 02/10) Postdoctoral Researcher, Michigan State University, MI.
(08/05-12/09) Graduate Research Assistant, Michigan State University, MI.
(09/03-08/05) Senior Research Fellow, Indian Veterinary Research Institute, India.
(07/03-09/03) Junior Research Fellow, HP Agricultural University, Palampur.
(09/01-07/03) Junior Research Fellow, G. B. Pant University, Pantnagar, India.
(03/99-09/01) Veterinary Clinics and Internship.

Certifications

(2001-Present) Himachal Pradesh Veterinary Council
(2001-Present) Veterinary Council of India

Honors and Awards

  • The Roger O. McClellan Research Award for Comparative & Veterinary and Toxicologic & Exploratory Pathology specialty sections at Society of Toxicology Conference, 2010 at Salt Lake City, USA.
  • Dissertation Completion Fellowship from Genetics Program, Michigan State University during Fall, 2009.
  • Graduate Research Award “First Place” in Metal Speciality Section at Society of Toxicology Conference, 2009 at Baltimore, USA.
  • Dissertation Completion Fellowship from Graduate school, Michigan State University during Summer, 2009.
  • Junior Investigator Travel Fellowship from The New York Academy of Sciences to attend “Hypoxia and Consequences: From Molecule and Malady” meeting, The New York Academy of Sciences, 2009 at New York, USA.
  • Student/Postdoctoral-Young Investigator Merit Award by Association of Scientists of Indian Origin (ASIO) at Society of Toxicology Conference, 2009 at Baltimore, USA.
  • Graduate Student Travel Award from Society of Toxicology to attend Society of Toxicology Conference, 2009 at Baltimore, USA.
  • Travel Fellowship from Graduate School, Michigan State University to attend Society of Toxicology Conference, 2009 at Baltimore, USA.
  • Travel Fellowship from Genetics Program to attend “Hypoxia and Consequences: From Molecule and Malady” meeting, The New York Academy of Sciences, 2009 at New York, USA.
  • Best Poster Presentation Award by a Graduate Student, Phi Zeta Research Day, College of Veterinary Medicine, Michigan State University, 2008
  • Travel Fellowship from Center for integrative toxicology to attend Society of Toxicology Conference, 2008 at Seattle, USA.
  • Qualified national level CSIR (Council for Scientific and Industrial Research)
    -Human Resource Development Group Junior Research Fellowship (JRF) for PhD (2002-2003) held on 23rd June 2002.
  • Qualified national level National Eligibility Test (NET) for Lectureship conducted by CSIR-UGC held on 22nd December 2002.
  • Qualified national level National Eligibility Test (NET) for Lectureship conducted by Indian Council for Agricultural Research (ICAR).
  • Awarded fellowship as Junior Research Fellowship (JRF) under Department of Biotechnology (DBT), New Delhi, sponsored project entitled “Development of PCR based assay for molecular diagnosis of Chlamydia psittaci”.
  • Awarded Junior Research Fellowship (JRF), sponsored by ICAR for pursuing MVSc.
  • Recipient of College Merit Scholarship in the First and Second professional B.V.Sc. & A.H. in the academic year of 1996-1997 and 1997-1998 respectively.

Publications

Please see Pubmed feed in the righthand column for links to current publications.

Erica M. Sparkenbaugh, Yogesh saini, John J LaPres, Jane Maddox, PE Ganey and Robert A. Roth. The Role of Hypoxia Inducible Factor-1 alpha (HIF-1α) in Acetaminophen Hepatotoxicity. J Pharmacol Exp Ther. 2011 Aug;338(2):492-502.

Sonika Patial, Shipra Shahi, Yogesh Saini, Daniel M. Appledorn, John J. LaPres, Andrea Amalfitano and Narayanan Parameswaran. G-protein coupled receptor kinase 5 (GRK5) regulates LPS induced NFκB pathway and is necessary for the production of pro inflammatory cytokines and chemokines in LPS induced septic shock model of mice. Journal of Cellular Physiology, 2011 May; 226 (5): 1323-33.

Sonika Patial, Yogesh Saini, Daniel M. Appledorn, Gerald W. Dorn, John J Lapres, Andrea Amalfitano, Patricia Senagore and Narayanan Parameswaran. Myeloid-specific GPCR kinase-2 negatively regulates NFκB1p105-ERK pathway and limits endotoxemic shock in mice. Journal of Cellular Physiology, 2011 Mar; 226 (3): 627-37.

Yogesh Saini, Krista K. Greenwood, Christian Merrill, Kyung Y. Kim, Sonika Patial, Jack R. Harkema, John J. LaPres. Acute Cobalt-Induced Lung Injury and the Role of Hypoxia Inducible Factor 1α (HIF1α) in Modulating Inflammation. Toxicological sciences, 2010 Aug; 116 (2), 673-681.

Yogesh Saini, Kyung Y. Kim, Lori Bramble, Ryan Lewandowski, Jack R. Harkema, John J. LaPres. Role of Hypoxia Inducible Factor 1 alpha (HIF1α) in cobalt-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2010 Feb; 298(2):L139-47.

Yogesh Saini, Jack R. Harkema, John J. LaPres. HIF1α is essential for normal intrauterine differentiation of alveolar epithelium and surfactant production in the newborn lung of mice. Journal of Biological Chemistry, 2008 Nov 28; 283(48):33650-33657.

Sonika Patial, V.K. Chaturvedi, A. Rai, M. Saini, Rajesh Chandra, Yogesh Saini and Praveen K. Gupta. Virus neutralizing antibody response in mice and dogs with a bicistronic DNA vaccine encoding rabies virus glycoprotein and canine parvovirus VP2. Vaccine, 2007 May; 25:4020-4028.

Professional Activities

Nominated as Web Site Liaison and ToXchange Community Site Administrator for Comparative and Veterinary Specialty Section, Society for Toxicology, 2011-Present.

Elected as Postdoctoral Representative for Comparative and Veterinary Specialty Section, Society for Toxicology, 2011-Present.

Invited Oral Presentation Judge in University Research Day organized at The University of North Carolina, Chapel Hill, 2011.

Volunteered in Continuing Education session entitled “ Technologies and Tools for Toxicity Testing in the 21st Century” at the Society of Toxicology, 2010 at Salt Lake City, USA.

Served as a Chairperson in the poster session entitled “In Vitro-Metals” at the Society of Toxicology Conference, 2009 at Baltimore, USA.

Volunteered in Continuing Education session entitled “Immunology for toxicologists” at the Society of Toxicology Conference, 2009 at Baltimore, USA.

Served as a Poster judge in The Merck-Merial NIH Veterinary Scholars Symposium held at Michigan State University, 2008.

Professional Presentations

A Livraghi-Butrico, EA Duncan, Yogesh Saini, H Dang, CM Doerschuk, WK O’Neal, RC Boucher. Mechanisms of host defense during airway mucus obstruction in Scnn1b transgenic mice, a mouse model of COPD. Aspen Lung Conference, 2011.

Shipra Shahi, Sonika Patial, Yogesh Saini, Daniel Appledorn, John Lapres, Andrea Amalfitano, and Narayanan Parameswaran. G-protein coupled receptor kinase-5 mediates Toll-like receptor-4-induced NF B activation in primary macrophages and in vivo in mice. AAI Annual Meeting Abstract published in J. Immunol., Apr 2010; 184: 94.11.

Yogesh Saini, Daher Aibo, Krista Greenwood, Lori Bramble, Jack R. Harkema and John J. LaPres. The role of hypoxia inducible factors 1 alpha (HIF1α) in cobalt-induced acute and sub-chronic lung inflammation. The Toxicologist, 1569 (325), 2010 (Abstract and Oral Presentation).

Yogesh Saini, Jack R. Harkema, John J. LaPres. The role of hypoxia inducible factors 1 alpha (HIF1α) in cobalt-induced acute and sub-chronic lung inflammation. Michigan Society of Toxicology meeting, 2009. (Abstract and Poster Presentation).

Erica M. Sparkenbaugh, Yogesh saini, John J LaPres, Jane Maddox, PE Ganey and Robert A. Roth. HIF1α deletion protects mice from acetaminophen hepatotoxicity and reduces activation of the hemostatic system. Michigan Society of Toxicology meeting, 2009. (Poster)

Yogesh Saini, Jack R. Harkema, John J. LaPres. The role of two hypoxia inducible factors (HIF1α and HIF2α) in murine lung development. Phi-zeta Day, 2009 (Abstract and Poster Presentation).

Yogesh Saini, Jack R. Harkema, John J. LaPres. The role of hypoxia inducible factors 1 alpha (HIF1α) in cobalt-induced lung inflammation. Phi-zeta Day, 2009 (Abstract and Oral Presentation).

Sonika Patial, Yogesh Saini, Daniel M. Appledorn, Gerald W. Dorn, John J Lapres, Andrea Amalfitano, Patricia Senagore and Narayanan Parameswaran. Myeloid-specific

G-protein coupled receptor kinase 2 (GRK2) is a negative regulator of inflammatory response in LPS-induced septic shock model of mice. MSU CVM Phi Zeta Research Day, 2009 (Abstract and Poster Presentation)

Yogesh Saini, Kyung Y. Kim, Jack R. Harkema, John J. LaPres. Hypoxia inducible factor 1 alpha (hif1α) protects mice lungs from cobalt-induced injury. Hypoxia and Consequences: From Molecule and Malady, The New York Academy of Sciences, 2009
(Abstract and Poster Presentation).

Yogesh Saini, Daher I. Aibo, Kyung Y. Kim, Jack R. Harkema, John J. LaPres. Hypoxia inducible factor 1 alpha (hif1α) mediates ozone-induced lung injury in mice. Hypoxia and Consequences: From Molecule and Malady, The New York Academy of Sciences, 2009 (Abstract and Poster Presentation).

Yogesh Saini, Kyung Y. Kim, Jack R. Harkema, John J. LaPres. Hypoxia inducible factor 1 alpha (hif1α) protects mice lungs from cobalt-induced injury. The Toxicologist, 1569 (325), 2009.

Yogesh Saini, Daher I. Aibo, Kyung Y. Kim, Jack R. Harkema, John J. LaPres. Hypoxia inducible factor 1 alpha (hif1α) mediates ozone-induced lung injury in mice. The Toxicologist, 2087 (434), 2009.

Yogesh Saini, Jack R. Harkema, John J. LaPres. HIF1α is essential for normal intrauterine differentiation of alveolar epithelium and surfactant production in the newborn lung of mice. Phi-zeta Day, 2008 (Abstract and Poster Presentation).

Yogesh Saini, Jack R. Harkema, John J. LaPres. Understanding Cobalt Chloride-Induced Lung Injury through Cytometric, Metabolomic, Proteomic, and Histological Analysis of Bronchioalveolar Lavage Fluid (BALF). The Toxicologist, 2092 (430), 2008.

Sonika Patial, Praveen K. Gupta, A. Rai, V. K. Chaturvedi, Yogesh Saini and A.K. Tiwari. Bivalent DNA vaccine encoding Rabies virus glycoprotein and Canine parvovirus VP2 genes confers immune responses and protection comparable to monovalent DNA vaccines. International Symposium on Management of Vector-Borne Viruses 7-10 February 2006.

Membership

(2010-present) Regular Member: American Physiological Society
(2009-present) Sigma Xi Society
(2009-present) New York Academy of Sciences
(2007-present) Society of Toxicology
(2008-present) Association of Scientists of Indian Origin -SOT
(2009-present) Comparative and Veterinary Specialty Section-SOT
(2001-present) Himachal Veterinary Council/ Veterinary Council of India.

Contact Information

7013 Thurston-Bowles Bldg.
The University of North Carolina at Chapel Hill
Campus Box #7248
Chapel Hill, NC 27599
Phone: (919) 966-9142
Email: sainiyog@gmail.com

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