UNC has developed the capacity to measure the respiratory microbiome with 16S-454 pyrosequencing technologies (see Figure 22). This technique has already been applied to studies of acute exacerbations in CF and COPD and measurement of antibiotic effects.
In sum, the UNC CF Center has a diverse array of capabilities for performing first in man Phase I clinical studies of novel therapeutic agents and is highly motivated to perform such studies.
|Figure 22. 16S pyrosequencing analyses of human respiratory microbiome. Distribution of microbiome of CF (L) and normal (R) induced sputum as determined by 16S-454 pyrosequencing.|
Questions? If you are interested in learning more about how the UNC CF Center can help further your research, or are interested in collaborating with us, please contact our CF Center Director, Dr. Richard Boucher:
7011 Thurston-Bowles Bldg.
The University of North Carolina at Chapel Hill
Campus Box #7248
Phone: (919) 966-1077
Fax: (919) 966-5178