|Figure 17. Whole histologic sections of βENaC and wild type (WT) mice, stained with AB-PAS. Note mucus-obstructed airway in βENac-Tg mice (upper left). Mucus obstruction is cleared with treatment with ENaC blocker (upper right). WT controls shown below. See full-size image...|
The UNC CF Center has numerous animal models of lung diseases, including the first “CF mouse” (UNCtm null). Current gene-targeted models include MUC1, 4, and 16 -/- mice, P2Y2-R -/- and P2Y4-R -/- mice, and pannexin -/- mice.
In addition, the UNC CF Center has the muco-obstructive βENaC transgenic mouse. βENaC mice have been crossed onto multiple strains and differing levels of transgene expression have developed. The mice exhibit a phenotype of airway surface liquid volume depletion, mucus hyperconcentration and adhesion, inflammation, early bacterial infection, airway re-modeling, and emphysema. βENaC mice have been used for multiple drug studies, including ENaC blockers (Figure 17), steroids, macrolides, and inhaled osmolytes.
Questions? If you are interested in learning more about how the UNC CF Center can help further your research, or if you are interested in collaborating with us, please contact our CF Center Director, Dr. Richard Boucher:
7011 Thurston-Bowles Bldg.
The University of North Carolina at Chapel Hill
Campus Box #7248
Phone: (919) 966-1077
Fax: (919) 966-5178