STORZ endoscopy has recently developed an endoscope that may be used to perform colonoscopy with biopsy in mice and rats . With this system it is possible to visualize colonic cancers and/ or colonic inflammation. Additionally, it is possible to obtain colonic biopsies e.g. for histology using a flexible biopsy forceps with a diameter of 3 Fr.

Contact:

Hans Herfarth, MD, PhD (Director)
919-966-8946
hherf@med.unc.edu

PUBLICATIONS

Modulation of the intestinal microbiota alters colitis-associated colorectal cancer susceptibility.
Uronis JM, Mühlbauer M, Herfarth HH, Rubinas TC, Jones GS, Jobin C.
PLoS One. 2009 Jun 24;4(6):e6026.PMID: 19551144

Flat colorectal cancers are genetically determined and progress to invasion without going through a polypoid stage.
Uronis JM, Herfarth HH, Rubinas TC, Bissahoyo AC, Hanlon K, Threadgill DW.
Cancer Res. 2007 Dec 15;67(24):11594-600.PMID: 18089788

Related articlesFree articleGnotobiotic IL-10; NF-kappaB mice develop rapid and severe colitis following Campylobacter jejuni infection.
Lippert E, Karrasch T, Sun X, Allard B, Herfarth HH, Threadgill D, Jobin C.
PLoS One. 2009 Oct 20;4(10):e7413.PMID: 19841748

Tomato lycopene extract prevents lipopolysaccharide-induced NF-kappaB signaling but worsens dextran sulfate sodium-induced colitis in NF-kappaBEGFP mice.
Joo YE, Karrasch T, Mühlbauer M, Allard B, Narula A, Herfarth HH, Jobin C.
PLoS One. 2009;4(2):e4562. Epub 2009 Feb 23.PMID: 19234608

STORZ

Application

If you plan a project including mouse endoscopy, please submit an application first (short abstract about the background and aims of the project in the context of the planned endoscopy). An internal board of the CGIBD including the core director will review this abstract. If the project appears feasible for performing endoscopy, it will be necessary to obtain approval from the IACUC either by amending an existing animal protocol or by writing a new application.

Storz Equipment and Sample Images

Inflammation

Tumors