This symposium will feature speakers from core facilities and resource centers at UNC that focus on mouse model development.  The Animal Models Core provides a full range of genetic modification services for production of transgenic and knockout mice, including model design, transgene cloning and BAC recombineering, pronuclear microinjection, targeting vector construction, ES cell gene targeting, and blastocyst injection of targeted ES cells.  The Mutant Mouse Regional Resource Center functions as a repository and informatics database for mutant strains of mice; the center at UNC is one of four collaborating centers sponsored by the National Center for Research Resources (NCRR) at NIH.  The Collaborative Cross is a panel of inbred mouse lines developed as an optimal model for human genetic diversity.  The Gnotobiotic Core of the Center for Gastrointestinal Biology and Disease is available for projects requiring germ-free inbred and outbred rodent strains.

Speakers

Dale O. Cowley          Animal Models Core for Transgenic and Knockout Mice

Jackie Brooks             The Mutant Mouse Regional Resource Center (MMRRC)

Darla Miller                 Collaborative Cross, Center for Integrated Systems Genetics

Maureen A. Bower     National Gnotobiotic Rodent Resource Center (NGRRC)