The R. L. Juliano Structural Bioinformatics Core Facility (SBI Core) is a computational core that trains researchers in computational structural biology techniques. Researchers have access to state-of-the-art software tools for protein and DNA sequence analysis, protein fold determination, homology modeling, active site identification, and analysis of the effects of various mutations on the structure and function of the protein. As researchers gain experience in computational techniques, they are incorporating more varied and computationally demanding techniques into their research. Researchers have now moved beyond homology modeling and have begun to incorporate molecular dynamics, NMR spectroscopy, and X-ray crystallography into their research efforts. Computational structural analyses, in particular, are absolutely critical for drug design and for understanding the role of molecules in disease. Over 250 UNC-CH researchers have utilized the SBI core since its establishment.
Researchers receive training in computational structural biology techniques through workshops and individual one-on-one sessions with the Executive Director. Please schedule an appointment with the Executive Director to explore applying these techniques to your research project. The Structural Bioinformatics Core is a recharge center. Please contact the director for estimates of cost.
To learn about available software packages go to Computational Tools.
For examples of current research using our tools, please visit Research Applications.