Understanding the Response to Fesoterodine through Genetic Evaluation in the Elderly (URGE)


NIH National Institute on Aging (NIA)

Principal Investigator

Dr. Jennifer Wu, Obstetrics and Gynecology

Project Run Dates

8/1/2012 to 7/31/2014



Urge urinary incontinence, characterized by unpredictable and embarrassing large volume urine leakage, is a major health issue for elderly women, as it is incredibly common and significantly impairs quality of life. Although anticholinergic medications are the most common therapy, the investigators are unable to predict an individual's response to a particular drug in terms of both effectiveness and side effects. Through genetic evaluation, the investigators have the potential to personalize and optimize drug therapy for millions of elderly women suffering from urge incontinence.


Associated Publications and other materials

Study Record Detail via Clinical Trials.gov


Associated Award Numbers: A14-0194-001, A14-0194-002

Associated Sponsor Award Numbers: 5-R03-AG042335-03, 5-R03-AG042335-02