Upstream maternal lifestyle factors, interleukin-6 and childhood growth from birth to age 2


American Diabetes Association

Principal Investigator

Dr. Wanda Nicholson, Obstetrics and Gynecology

Project Run Dates

3/1/2010 to 8/31/2012



The objective of this Clinical Research proposal is to prospectively follow the offspring of these mothers to determine the effect of upstream maternal lifestyle factors on childhood growth and adiposity in 120 offspring. We will collect anthropometric measures at 6 weeks and 6, 12, 18, and 24 months. Primary outcome measures will be 1) weight; 2) length and height; 3) weight-for age and 4) weight-for-height; and 5) percent body fat, assessing the influence of maternal dietary intake and physical activity collected at baseline (first trimester) and serum IL-6 levels in the first, second, and third trimesters. Secondary outcomes will include body mass index. Our objective is to follow the offspring of a sample of mothers from the PID Study to obtain pilot data on the longitudinal effect of maternal lifestyle factors on early childhood growth trajectories. Our goal is to use the data from this pilot study to submit a strong R01 application for a larger cohort and long-term childhood followup.


Associated Publications and other materials