Donna Culton, MD, PhD Laboratories

Autoimmunity of Pemphigus

Culton Photo Publications

The long term goal of Dr. Culton's laboratory is to better understand the development of cutaneous autoimmune disease with particular interest in autoreactive B lymphocyte development, regulation, and contribution to disease.

We are currently studying pemphigus as a disease model of autoimmunity.  Pemphigus is a group of life threatening blistering autoimmune diseases of the skin caused by autoantibodies directed against the cell adhesion molecules desmoglein 1 (dsg1) and desmoglein 3 (dsg3).  The aim of our research is to understand the development and behavior of anti-desmoglein (dsg) B cells and the autoantibodies they eventually produce, and to clarify their role in the patholgenesis of pemphigus.