Luis A. Diaz, MD Laboratories

Autoimmunity of Pemphigus


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Research Scientists:
Phillip Prisayanh, MS

Postdoctoral Fellows:
Mike Maldonado, MD

Students:
Kirk James, MS

The research aims carried out in these laboratories center on disclosing the immunopathological mechanisms operating in pemphigus vulgaris (PV) and pemphigus foliaceus (PF).  Some of these studdies address the distinct anti-desmosomal autoantibody subpopulations associated with disease phenotypes in PV and PF.  Additionally, we are investigating the etiology of Brazilian PF (Fogo Selvagem) as a joint project with Brazilian investigators.  The research projects of this laboratory are supported by NIH.  Our laboratories are credited with the following landmark research studies during the last 30 years:
  • Developing the animal model of PV by passive transfer of human autoantibodies to neonatal mice
  • Developing the animal model of PF by passive transfer of human autoantibodies to neonatal mice.
  • Description of the mucosal and mucocutaneous phenotypes of pemphigus vulgaris
  • Epidemiological and immunological studies on endemic pemphigus foliaceus in Brazil
  • lgG4 anti-desmoglein 1 restriction of the humoral lgG response in endemic pemphigus foliaceus
  • The unique lgM anti-desmoglein 1 response in endemic pemphigus foliaceus