Laurence Katz, M.D., Associate Professor of Emergency Medicine, has received a two-year $500,000 award from NIH/NINDS to support his study “Regulated Hypothermia to Treat Hypoxic-Ischemic Brain Injury.” Hypothermia is a breakthrough therapy for brain ischemia, yet every year there are still hundreds of thousands of patients’ who suffer permanent neurological deficits and death after brain ischemia from cardiac arrest, stroke, near drowning and traumatic brain injury. Mild hypothermia when induced in a timely manner reduces ischemic brain injury; however, forcing the body’s temperature (forced hypothermia) below its normal set point of 37^oC is also stressful to the patient, fraught with potentially serious adverse events and is difficult to induce, particularly prehospital where it may be most effective. The purpose of this project is to develop drug-induced regulated hypothermia to treat brain ischemia.