Basic Science

Area of Study: Recovery after trauma

Faculty member: Samuel McLean, MD / TRYUMPH Research Program

Project Description: The goal of our research is to improve recovery after traumatic events such as motor vehicle collision, sexual assault, and burn injury.  Current activities include Project CRASH (1R01AR056328), which is currently collecting genetic and non-genetic risk factor and outcome data on 1000 MVC patients at six US ED sites; The Women’s Health Study, which similarly collecting data on sexual assault survivors at ED sites across North Carolina, and a pharmacologic study to improve outcomes after burn. Educational activities include a weekly TRYUMPH Program journal club, a weekly Center meeting with frequent extramural speakers, and a weekly meeting discussing the molecular biology work of the Center.

Area of Study: Translational research on therapeutic hypothermia and infrared imaging.

Faculty member: Laurence Katz MD

Project Description: Our group studies thermophysiology in order to develop medications to optimize therapeutic hypothermia to treat acute ischemia with a particular focus on brain injury. We collaborate with members of the Biomedical Research Imaging Center (BRIC), Duke University and the military.

Area of Study: Trauma and cardiac resuscitation

Faculty member: James Manning, MD

Project Description: Experimental studies of hemorrhagic shock and cardiac resuscitation. Dr. Manning’s research focuses upon novel strategies to treat hemorrhagic shock and provide physiologic and metabolic support during cardiac resuscitation. His work is funded by the DOD and Naval Medical Research Center .