Carol G. Shores, MD, PhD, FACS

Associate Professor

Specialty:

Detection of micrometastasis, study of gene expression in radiation and chemotherapy resistance, and development of novel therapies for head and neck cancer

Education:

• PhD: Dept. of Biochemistry, University of North Carolina at Chapel Hill, 1988

• Postdoctoral Fellowship: Cell Biology, Glaxo Research Institute, RTP, NC, 1988-1991

• Medical School: University of North Carolina School of Medicine, 1995

• Internship: General Surgery, UNC, 1995-1996

• Residency: Dept. of Otolaryngology/Head and Neck Surgery, UNC, 1996-2001

Professional Experience:

• Associate Professor, Department of Otolaryngology/Head and Neck Surgery, UNC, 2006-present
• Assistant Professor, Department of Otolaryngology/Head and Neck Surgery, UNC, 2001-2006
• Assistant Professor, Division of Otolaryngology/Head and Neck Surgery, Dept. of Surgery, UNC, 2000-2001

Recent Honors:

• Elected to the University of North Carolina School of Medicine's Academy of Educators as a Fellow, March 2007
• American Academy of Otolaryngology-Head and Neck Surgery Honor Award, June 2005
• Lloyd Storrs Resident Research Award, American Laryngological, Rhinological and Otological Society Southern Section Meeting, Received by Adam Zanation PGY3, January 2005
• Excellence in Teaching Award, University of North Carolina School of Medicine, 2002, 2004

Recent Publications:

• Roberts J, Shores C and Rose AS, Surgical treatment warranted in aggressive central giant cell granuloma: a report of two cases, Ear, Nose and Throat Journal, 2007, Accepted

• Lee S, Shores C and Weissler M. Surgical salvage after failed primary concomitant chemoradiation, Current Opinion in Otolaryngology and Head & Neck Surgery 2007, Accepted

• Bryson P, Shores C, Hart C, Thorne L, Patel M, Richey L, Farag A and Zanation A. Immunohistochemical Distinction of Follicular Thyroid Adenomas and Follicular Carcinomas. Archive of Otolaryngology-Head & Neck Surgery 2007, Accepted

• Cannon TY, Guttridge D, Dahlman J, George JR, Lai V, Shores C, Buzková P and Couch ME, The Effect of Altered Toll-like Receptor 4 Signaling on Cancer Cachexia. Arch Otolaryngol Head Neck Surg. 2007 133:1263-9

• Cannon T, Couch M, Yin X, Guttridge D, Lai V and Shores C. Comparison of Animal Models for Head and Neck Cancer Cachexia, 2007, Laryngoscope, 2007 Oct 4; [Epub ahead of print].

• Cannon T, Shores C, Yin X, Dahlman J, Guttridge D, Lai V, George J, Buzkova P, Couch M. Immunocompetent murine model of cancer cachexia for head and neck squamous cell carcinoma. Head Neck. 2007 Jul 26; [Epub ahead of print]

• Lai V, George J, Richey L, Kim HJ, Cannon T, Shores C and Couch M. Results of a pilot study of the effects of celecoxib on cancer cachexia in patients with cancer of the head, neck and gastrointestinal tract, Head & Neck 2007 Jul 5 Epub ahead of print.

• Richey LM, George JR, Couch ME, Kanapkey BK, Yin X, Cannon T, Stewart P, Weissler MC, Shores CG. Defining cancer cachexia in head and neck squamous cell carcinoma. Clin Cancer Res 2007;12(22):6561-67.

• George J, Cannon T, Lai V, Richey L, Zanation A, Hayes DN, Shores C, Guttridge D and Couch M. Cancer cachexia syndrome in head and neck cancer patients Part II. Pathophysiology, Head & Neck 2007, 29:497-507.

• Couch M, Lai V, Cannon T, Guttridge D, Zanation A, George J, Hayes DN, Zeisel S and Shores C. Cancer cachexia syndrome in head and neck cancer patients Part I. Diagnosis, impact on quality of life and survival and treatment, Head & Neck 2007, 29:401-11.

• Richey LM, Shores CG, George J, Lee S, Couch MJ, Sutton DK, Weissler MC. The effectiveness of salvage surgery after the failure of primary concomitant chemoradiation in head and neck cancer, Otolaryngology-Head and Neck Surgery 2007, 132:98-103.

• Richey LM, Olshan AF, George J, Shores CG, Zanation AM, Cannon T and Weissler MC. Incidence and survival rates for young blacks with nasopharyngeal carcinoma in the United States. Arch Otolaryngol Head Neck Surg 2006, 132:1035-40.

• Knoll C, Smith R, Shores C and Blatt J. Hearing Genes and Cisplatin Deafness: a Pilot Study, Laryngoscope 2006, 116:72-4.

• Zanation AM, Sutton DK, Couch M, Weissler MC, Shockley W and Shores CG. Accuracy, and Implications for Patient Management of [18F]-2-Fluorodeoxyglucose-Positron Emission/Computerized Tomography (PET/CT) for Head and Neck Tumors, Laryngoscope 2005;115:1186-90.

• Moss JR, Zanation AM and Shores CG. ACE Inhibitor Associated Recurrent, Intermittent Parotid Gland Swelling Otolaryngology-Head and Neck Surgery 2005;133:992-4.

• Yin X, Zhang H, Burrows F, Zhang L and Shores CG. Potent Activity of a Novel Dimeric Hsp90 inhibitor Against Head and Neck Squamous Cell Carcinoma In Vitro and In Vivo, Clinical Cancer Research 2005; 15:3889-96

• Zanation AM, Yin X, Shores CG and Yarbrough WG. Phenotypic and Microarray Gene Expression Analysis of Tri-Dimensional Raft Modeled Human Head and Neck Squamous Cell Carcinoma Otolaryngology-Head and Neck Surgery 2004;131:577-84.

• Shores CG, Yin X, Yarbrough WG. Clinical Evaluation of a New Molecular Method for Detection of Micrometastases in Head and Neck Squamous Cell Carcinoma Archives of Otolaryngology/Head and Neck Surgery, 2004;130:937-942

• Cullen RD, Buchman CA, Brown CJ, Copeland BJ, Zdanski C, Pillsbury HC, Shores CG. Cochlear Implantation for Children with GJB2-Related Deafness Laryngoscope 2004;114:1415-1419

• Chung, CH, Parker JS, Karaca G, Wu J, Funkhouser WK, Moore D, Butterfoss D, Xiang D, Zanation A, Yin X, Shockley WW, Weissler MC, Dressler LG, Shores CG, Yarbrough WG and Perou CM. Molecular Classification of Head and Neck Squamous Cell Carcinoma using Patterns of Gene Expression Cancer Cell 2004;5:489-500.

• Becker MT, Yu KK, Shores CG, Yarbrough WG. Molecular assay to detect metastatic head and neck squamous cell carcinoma. Archives of Otolaryngology/Head and Neck Surgery 2004;130: 21-7