Carol G. Shores, MD, PhD, FACS

Associate Professor

Specialty:

Head and neck surgical oncology, including salivary malignancies, thyroid surgery, and surgical airway management.

Education:

• PhD: Dept. of Biochemistry, University of North Carolina at Chapel Hill, 1988

• Postdoctoral Fellowship: Cell Biology, Glaxo Research Institute, RTP, NC, 1988-1991

• Medical School: University of North Carolina School of Medicine, 1995

• Internship: General Surgery, UNC, 1995-1996

• Residency: Dept. of Otolaryngology/Head and Neck Surgery, UNC, 1996-2001

Professional Experience:

• Associate Professor, Department of Otolaryngology/Head and Neck Surgery, UNC, 2006-present
• Assistant Professor, Department of Otolaryngology/Head and Neck Surgery, UNC, 2001-2006
• Assistant Professor, Division of Otolaryngology/Head and Neck Surgery, Dept. of Surgery, UNC, 2000-2001

Recent Honors:

• 2011 Nominated to the WHO Global Initiative for Emergency and Essential Surgical Care (GIEESC) Surgical Mission & Partnerships Coordinating Committee.
• 2009 Inductee into the YWCA Academy of Women in Science and Technology. The mission of the YWCA of the Greater Triangle Area is to empower women and eliminate racism.

• Elected to the University of North Carolina School of Medicine's Academy of Educators as a Fellow, March 2007
• UNC Academy of Educators Fellow 2007
• American Academy of Otolaryngology-Head and Neck Surgery Honor Award, June 2005
• Lloyd Storrs Resident Research Award, American Laryngological, Rhinological and Otological Society Southern Section Meeting, Received by Adam Zanation PGY3, January 2005
• Excellence in Teaching Award, University of North Carolina School of Medicine, 2002, 2004

• Herbert H Fritz Special Merit Award for outstanding academic achievement 1991 to 1992 academic year.
• Medical Alumni Loyalty Fund Scholar 1993 to 1994.  One of three students chosen for academic excellence, service to humanity and breadth of personal and educational experiences.
• Member Alpha Omega Alpha 1994
• G. Slaughter Fitz-Hugh Award 1998, for most excellent research paper presented to the American Laryngological, Rhinological and Otological Society Southern Section Meeting.

Recent Publications:

• Lai V, George J, Richey L, Kim HJ, Cannon T, Shores C and Couch M. Results of a pilot study of the effects of celecoxib on cancer cachexia in patients with cancer of the head, neck and gastrointestinal tract, 2008 Head & Neck 30:67-74 PMID: 17615567
• Bryson P, Shores C, Hart C, Thorne L, Patel M, Richey L, Farag A and Zanation A. Immunohistochemical Distinction of Follicular Thyroid Adenomas and Follicular Carcinomas. 2008 Archive of Otolaryngology-Head & Neck Surgery 134:581-6 PMID: 18559722
• CannonT, Shores C, Yin X, Dahlman J, Guttridge D, Lai V, George J, Buzkova P and Couch M. Immunocompetent murine model of cancer cachexia for head and neck squamous cell carcinoma. 2008 Head Neck. 30:320-6 PMID: 17657796
• Lee S, Shores C and Weissler M.  Surgical salvage after failed primary concomitant chemoradiation, 2008 Current Opinion in Otolaryngology and Head & Neck Surgery 16:135-40 PMID: 18327032
• Roberts J, Shores C and Rose AS, Surgical treatment warranted in aggressive central giant cell granuloma: a report of two cases, Ear Nose Throat J. 2009 88:E8-E13 PMID: 19291624
• Patel MR, Bryson PC, Shores CG, Hart CF, Thorne LB, Deal AM, Zanation AM. Trefoil factor 3 immunohistochemical characterization of follicular thyroid lesions from tissue microarray. Arch Otolaryngol Head Neck Surg. 2009 135(6):590-6 PMID: 19528408.
• Andrews E, Shores C, Hayes DN, Couch M, Southerland J, Morris D, Seaman WT, Webster-Cyriaque J. Concurrent human papillomavirus-associated tonsillar-carcinoma in 2 couples J Infect Dis. 2009 Sep 15;200(6):882-7, PMID: 19678755.
• Yin X, Zhang H, Lundgren K, Wilson L, Burrows F and Shores CG. BIIB021, A Novel Hsp90 Inhibitor, Sensitizes Head And Neck Squamous Cell Carcinoma To Radiotherapy. Int J Cancer. 2010 Mar 1;126(5):1216-25PMID: 19662650.
• Shah RN, Cannon T and Shores CG. Infections and Disorders of the Neck and Upper Airway. In: Emergency Medicine: A Comprehensive Study Guide, 7^th Edition. Tintinalli JE, Stapczynski JS, Ma OJ, Cline D, Cydulka R and Meckler G (eds.). New York: McGraw-Hill, (Pub date Oct 2010)
• Patel MR, Cannon T and Shores CG. Complications of Airway Devices. In: Emergency Medicine: A Comprehensive Study Guide, 7^th Edition. Tintinalli JE, Stapczynski JS, Ma OJ, Cline D, Cydulka R and Meckler G (eds.). New York: McGraw-Hill, (Pub date Oct 2010)
• Tang W, Harmon P, Gulley ML, Mwansambo C, Kazembe PN, Martinson F, Wokocha C, Kenney SC, Hoffman I, Sigel C, Maygarden S, Hoffman M and Shores C. Viral Response to Chemotherapy in Endemic Burkitt Lymphoma. Clin Cancer Res. 2010 Mar 16. Clin Cancer Res. 2010 Apr 1;16(7):2055-64 PMID: 20233888
• Yin X, Hayes DN, Shores CG. Antitumor activity of enzastaurin as radiation sensitizer in head and neck squamous cell carcinoma. Head Neck. 2010 Oct 21. [Epub ahead of print] PMID: 20967867
• Qureshi JS, Samuel J, Lee C, Cairns B, Shores C and Charles AG. Surgery and Global Public Health: The UNC-Malawi Surgical Initiative as a Model for Sustainable Collaboration. World J Surg. 2011 Jan;35(1):17-21. PMID: 21052998
• Patel SC, Couch M, Weissler M, Shores C, Hackman T, Zanation A, Hayes DN, Chera BS. Increasing Incidence Trends of Squamous Cell Carcinoma of the Oral Tongue in Young White Females, ages 18-44 J Clinical Oncol, 2011 29(11):1488-94 PMID:21383286
• Fried D, Khandani A, Shores C, Weissler M, Hayes N, Hackman T, Rosenman J and Chera BS Matched Cohort Analysis of the Effect of Pre-treatment Positron Emission Tomography on Clinical Outcomes of Head and Neck Cancer Patients Treated with Definitive Chemoradiotherapy, Head and Neck, 2011 accepted
• Patel MR, Stadler ME, Deal, Kim HS, Shores CG, MD, PhD, Zanation AM. STT3A, C1orf24, TFF3: Putative Markers for Characterization of Follicular Thyroid Neoplasms from Fine Needle Aspirates, Laryngoscope, 2011 121:983-9 PMID:21520112
• Fried D, Khandani A, Shores C, Weissler M, Hayes N, Hackman T, Rosenman J and Chera BS Matched Cohort Analysis of the Effect of Pre-treatment Positron Emission Tomography on Clinical Outcomes of Head and Neck Cancer Patients Treated with Definitive Chemoradiotherapy, Head and Neck, 2011 [Epub ahead of print] PMID: 21853498
• Patel MR, Stadler ME, Deal, Kim HS, Shores CG, MD, PhD, Zanation AM. STT3A, C1orf24, TFF3: Putative Markers for Characterization of Follicular Thyroid Neoplasms from Fine Needle Aspirates, Laryngoscope, 2011 121:983-9 PMID:21520112
• Ang MK, Patel MR, Yin XY, Fritchie K, Zhao N, Liu Y, Wilkerson M, Weissler MC, Shockley W, Couch ME, Zanation AM, Hackman T, Chera B, Harris SL, Miller CR, Thorne LB, Hayward MC, Funkhouser WK, Olshan AF, Shores CG and Hayes DN. High XRCC1 Expression Is Associated With Poorer Survival In Patients With Head And Neck Squamous Cell Carcinoma, Clinical Cancer Research 2011 Sep 9. [Epub ahead of print] PMID:21908577
• Ardeshirpour F, Ladner KM, Shores CG, Shockley, WW. The Use of Ultrasound in Defining Nasal Fractures ENT Journal 2010 accepted
• Apisarnthanarax S, Dhruva N, Ardeshirpour F, Tepper J, Shores C, Rosenman JG, Shockley WW, Hayward M and Hayes DN. Concomitant Radiotherapy and Chemotherapy for High Risk Nonmelanoma Skin Carcinomas of the Head and Neck, Int J Surg Oncol 2011 accepted
• Deal A, Thorp B, Patel M, Bryson PC, Leight D, Cannon T, Shores C and Zanation A. Liver Function Tests: Inadequate Modality for Detection of Liver Metastasis in Head and Neck Carcinoma Oto Head & Neck, 2011 accepted

• Roberts J, Shores C and Rose AS, Surgical treatment warranted in aggressive central giant cell granuloma: a report of two cases, Ear, Nose and Throat Journal, 2008, Accepted

• Lee S, Shores C and Weissler M. Surgical salvage after failed primary concomitant chemoradiation, Current Opinion in Otolaryngology and Head & Neck Surgery 2008;16:135-40.

• Bryson P, Shores C, Hart C, Thorne L, Patel M, Richey L, Farag A and Zanation A. Immunohistochemical Distinction of Follicular Thyroid Adenomas and Follicular Carcinomas. Archive of Otolaryngology-Head & Neck Surgery 2008;134:581-6.

• Cannon TY, Guttridge D, Dahlman J, George JR, Lai V, Shores C, Buzková P and Couch ME, The Effect of Altered Toll-like Receptor 4 Signaling on Cancer Cachexia. Arch Otolaryngol Head Neck Surg. 2007 133:1263-9

• Cannon T, Couch M, Yin X, Guttridge D, Lai V and Shores C. Comparison of Animal Models for Head and Neck Cancer Cachexia, 2007, Laryngoscope, 2007 Oct 4; [Epub ahead of print].

• Cannon T, Shores C, Yin X, Dahlman J, Guttridge D, Lai V, George J, Buzkova P, Couch M. Immunocompetent murine model of cancer cachexia for head and neck squamous cell carcinoma. Head Neck. 2007 Jul 26; [Epub ahead of print]

• Lai V, George J, Richey L, Kim HJ, Cannon T, Shores C and Couch M. Results of a pilot study of the effects of celecoxib on cancer cachexia in patients with cancer of the head, neck and gastrointestinal tract, Head & Neck 2007 Jul 5 Epub ahead of print.

• Richey LM, George JR, Couch ME, Kanapkey BK, Yin X, Cannon T, Stewart P, Weissler MC, Shores CG. Defining cancer cachexia in head and neck squamous cell carcinoma. Clin Cancer Res 2007;12(22):6561-67.

• George J, Cannon T, Lai V, Richey L, Zanation A, Hayes DN, Shores C, Guttridge D and Couch M. Cancer cachexia syndrome in head and neck cancer patients Part II. Pathophysiology, Head & Neck 2007, 29:497-507.

• Couch M, Lai V, Cannon T, Guttridge D, Zanation A, George J, Hayes DN, Zeisel S and Shores C. Cancer cachexia syndrome in head and neck cancer patients Part I. Diagnosis, impact on quality of life and survival and treatment, Head & Neck 2007, 29:401-11.

• Richey LM, Shores CG, George J, Lee S, Couch MJ, Sutton DK, Weissler MC. The effectiveness of salvage surgery after the failure of primary concomitant chemoradiation in head and neck cancer, Otolaryngology-Head and Neck Surgery 2007, 132:98-103.

• Richey LM, Olshan AF, George J, Shores CG, Zanation AM, Cannon T and Weissler MC. Incidence and survival rates for young blacks with nasopharyngeal carcinoma in the United States. Arch Otolaryngol Head Neck Surg 2006, 132:1035-40.

• Knoll C, Smith R, Shores C and Blatt J. Hearing Genes and Cisplatin Deafness: a Pilot Study, Laryngoscope 2006, 116:72-4.

• Zanation AM, Sutton DK, Couch M, Weissler MC, Shockley W and Shores CG. Accuracy, and Implications for Patient Management of [18F]-2-Fluorodeoxyglucose-Positron Emission/Computerized Tomography (PET/CT) for Head and Neck Tumors, Laryngoscope 2005;115:1186-90.

• Moss JR, Zanation AM and Shores CG. ACE Inhibitor Associated Recurrent, Intermittent Parotid Gland Swelling Otolaryngology-Head and Neck Surgery 2005;133:992-4.

• Yin X, Zhang H, Burrows F, Zhang L and Shores CG. Potent Activity of a Novel Dimeric Hsp90 inhibitor Against Head and Neck Squamous Cell Carcinoma In Vitro and In Vivo, Clinical Cancer Research 2005; 15:3889-96

• Zanation AM, Yin X, Shores CG and Yarbrough WG. Phenotypic and Microarray Gene Expression Analysis of Tri-Dimensional Raft Modeled Human Head and Neck Squamous Cell Carcinoma Otolaryngology-Head and Neck Surgery 2004;131:577-84.

• Shores CG, Yin X, Yarbrough WG. Clinical Evaluation of a New Molecular Method for Detection of Micrometastases in Head and Neck Squamous Cell Carcinoma Archives of Otolaryngology/Head and Neck Surgery, 2004;130:937-942

• Cullen RD, Buchman CA, Brown CJ, Copeland BJ, Zdanski C, Pillsbury HC, Shores CG. Cochlear Implantation for Children with GJB2-Related Deafness Laryngoscope 2004;114:1415-1419

• Chung, CH, Parker JS, Karaca G, Wu J, Funkhouser WK, Moore D, Butterfoss D, Xiang D, Zanation A, Yin X, Shockley WW, Weissler MC, Dressler LG, Shores CG, Yarbrough WG and Perou CM. Molecular Classification of Head and Neck Squamous Cell Carcinoma using Patterns of Gene Expression Cancer Cell 2004;5:489-500.

• Becker MT, Yu KK, Shores CG, Yarbrough WG. Molecular assay to detect metastatic head and neck squamous cell carcinoma. Archives of Otolaryngology/Head and Neck Surgery 2004;130: 21-7