Julia S. Kimbell, PhD

Associate Professor

Specialty:
Research in biomathematical modeling; the effects of nasal anatomy and respiratory airflow patterns on the uptake and deposition of inhaled gases and particles in the nasal passages of rodents, primates, and humans

Education:

• Postdoctoral Fellowship: Chemical Industry Institute of Toxicology, 1989-1991
• PhD, Differential Geometry: Duke University, 1988
• MA, Mathematics, Duke University, 1984

Professional Experience:

• Associate Professor, Dept. of Otolaryngology/Head and Neck Surgery, UNC, 2009-present
• Consultant, The Hamner Institutes for Health Sciences, 2009-present
• Senior Investigator, The Hamner Institutes for Health Sciences, 2008
• Associate Investigator, The Hamner Institutes for Health Sciences (formerly CIIT Centers for Health Research), 2004-2007
• Scientist II, CIIT Centers for Health Research (formerly the Chemical Industry Institute of Toxicology), 1999-2004
• Scientist I, Chemical Industry Institute of Toxicology (CIIT), 1992-1999
• Postdoctoral Fellow, Department of Inhalation Toxicology and Biomathematical Modeling, CIIT; Drs. Tom Starr and Mel Andersen, mentors, 1989-1992
• Instructor, Department of Mathematics, Duke University, Fall 1988
• Research fellowship to conduct Ph.D. thesis work on optimal deformation of sheet metal, Dr. William K. Allard, advisor, 1985-1988
• Teaching Assistant, Department of Mathematics, Duke University, 1982-1985

Recent Publications:

• Garcia, G.J.M. and Kimbell, J.S. (2009). Deposition of inhaled nanoparticles in the rat nasal passages: Dose to the olfactory region. Inhal. Toxicol. In press, 11 pages.
• Garcia, G.J.M. and Kimbell, J.S. (2009). Septal deviation and nasal resistance: An investigation using virtual surgery and computational fluid dynamics. Submitted 8/2008, 26 typed pages.
• Corley, R.A., Minard, K.R., Kabilan, S., Einstein, D.R., Kuprat, A.P., Harkema, J.R., Kimbell, J.S., Gargas, M.L., and Kinzell, J.H. (2009). Magnetic resonance imaging and computational fluid dynamics (CFD) simulations of rabbit nasal airflows for the development of hybrid CFD/PBPK models. Inhal. Toxicol. In press, 7 pages.
• Garcia, G. J. M., Schroeter, J. D., Segal, R. A., Stanek, J., Foureman, G. L., and Kimbell, J. S. (2009). Dosimetry of nasal uptake of soluble and reactive gases: A first study of inter-human variability. Inhal. Toxicol. 21:607-618.
• Garcia, G.J.M., Tewksbury, E.W., Wong, B.A., and Kimbell, J.S. (2009). Inter-individual variability in nasal filtration as a function of nasal cavity geometry. J. Aerosol Med. and Pulm. Drug Delivery, 22:139-155.
• Ginsberg, G.L., Asgharian, B., Kimbell, J.S., Ultman, J.S., and Jarabek, A.M. (2008). Modeling approaches for estimating the dosimetry of inhaled toxicants in children. J. Toxicol. Environ. Health (Part A), 71:166-195. [Risk Assessment Award Winner, Annual Society of Toxicology meeting, 2009]
• Schroeter, J.D., Kimbell, J.S., Gross, E.A., Willson, G.A., Dorman, D.C., Tan, Y.M., and Clewell, H.J. 3rd (2008). Application of physiological computational fluid dynamics models to predict interspecies nasal dosimetry of inhaled acrolein. Inhal. Toxicol., 20(3):227-243.
• Segal, R.A., Kepler, G.M., and Kimbell, J.S. (2008). Effects of differences in nasal anatomy on airflow distribution: A comparison of four individuals at rest. Ann. Biomed. Eng. 36(11):1870-1882.
• Struve, M.F., Wong, V.A., Marshall, M.W., Kimbell, J.S., Schroeter, J.D., and Dorman, D.C. (2008). Nasal uptake of inhaled acrolein in rats. Inhal. Toxicol., 20(3):217-225.
• Carey, S.A., Minard, K.R., Trease, L.L., Wagner, J.G., Garcia, G.J.M., Ballinger, C.A., Kimbell, J.S., Plopper, C.G., Corley, R.A., Postlethwait, E.M., and Harkema, J.R. (2007). Three-dimensional mapping of ozone-induced injury in the nasal airways of monkeys using magnetic resonance imaging and morphometric techniques. Toxicol. Pathol., 35:27-40.
• Garcia, G.J.M., Bailie, N., Martins, D.A., Kimbell, J.S. (2007). Atrophic rhinitis: a CFD study of air conditioning in the nasal cavity. J. Appl. Physiol., 103:1082-1092.
• Kimbell, J.S., Segal., R.A., Asgharian, B., Wong, B.A., Schroeter, J.D., Southall, J.P., Dickens, C.J., Brace, G., and Miller, F.J. (2007). Characterization of deposition from current nasal spray devices using a computational fluid dynamics model of the human nasal passages. J. Aerosol Med., 20(1):59-74.
• Kimbell, J.S. (2006). Nasal dosimetry of inhaled gases and particles: Where do inhaled agents go in the nose? Toxicol. Pathol., 34:270-273.
• Schroeter, J.D., Kimbell, J.S., Andersen, M.E., and Dorman, D.C. (2006). Use of a pharmacokinetic-driven computational fluid dynamics model to predict nasal extraction of hydrogen sulfide in rats and humans. Toxicol. Sci., 94(2):359-367.
• Schroeter, J.D., Kimbell, J.S., and Asgharian B. (2006). Analysis of particle deposition in the turbinate and olfactory regions using a human nasal computational fluid dynamics model. J. Aerosol Med., 19(3):301-313.
• Schroeter, J.D., Kimbell, J.S., Bonner, A.M., Roberts, K.C., Andersen, M.E., and Dorman, D.C. (2006). Incorporation of tissue reaction kinetics in a computational fluid dynamics model for nasal extraction of inhaled hydrogen sulfide in rats. Toxicol. Sci., 90(1), 198-207.
• Wexler, D., Segal, R.A., and Kimbell, J.S. (2005). Aerodynamic effects of inferior turbinate reduction: Computational fluid dynamics simulation. Arch. Otolaryngol. Head Neck Surg., 131:1102-1107.
• Conolly, R.B., Kimbell, J.S., Janszen, D.B., Schlosser, P.M., Kalisak, D.L., Preston, J., and Miller, F.J. (2004). Human respiratory tract cancer risks of inhaled formaldehyde: Dose-response predictions derived from biologically-motivated computational modeling of a combined rodent and human dataset. Toxicol. Sci., 82(1):279-296.
• Kelly, J.T., Asgharian, B., Kimbell, J.S., and Wong, B.A. (2004). Particle Deposition in Human Nasal Airway Replicas Manufactured by Different Methods. Part I: Inertial Regime Particles. Aerosol Sci. Technol., 38:1063-1071.
• Kelly, J.T., Asgharian, B., Kimbell, J.S., and Wong, B.A. (2004). Particle deposition in human nasal airway replicas manufactured by different methods. Part II: Ultrafine particles. Aerosol Sci. Technol., 38:1072-1079.
• Conolly, R.B., Kimbell, J.S., Janszen, D.B., Schlosser, P.M., Kalisak, D.L., Preston, J., and Miller, F.J. (2003). Biologically motivated computational modeling of formaldehyde carcinogenicity in the F344 rat. Toxicol. Sci., 75:432-447. [Risk Assessment Award Winner, Annual Society of Toxicology meeting, 2004]