Paul B. Manis, PhD

Professor
Chief, Division of Research Training and Education

Specialty:

Cellular basis of auditory information processing, centra nervous system plasticity

Education:

• Ph.D., Neuroscience, University of Florida, Gainesville, FL, August 1981.

• Research Associate, Dept. of Neuroscience., University of Florida College of Medicine, Gainesville FL, 1981-1982.

• Postdoctoral Fellow, Dept. of Cell Biology (Anatomy) Vanderbilt University School of Medicine, Nashville, TN, 1982-1985. 

Professional Experience:

• Professor and Chief, Division of Research Training and Education, Dept. of Otolaryngology/Head and Neck Surgery, UNC, July 2001 - present
• Professor and Director, Research Training and Education, Division of Otolaryngology/Head and Neck Surgery, Dept. of Surgery, UNC, June 2000 - July 2001
• Professor, Division of Otolaryngology/Head and Neck Surgery, Dept. of Surgery, UNC, Nov. 1999 - June 2000
• Visiting Professor, Division of Otolaryngology/Head and Neck Surgery, Dept. of Surgery, UNC, July 1999 - Nov. 1999
• Associate Professor of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore MD, Nov. 1991 - June 1999
• Associate Professor of Neuroscience, Johns Hopkins University School of Medicine, Nov. 1991 - June 1999
• Associate Professor of Biomedical Engineering, Johns Hopkins University School of Medicine, Nov. 1991 - June 1999
• Assistant Professor of Otolaryngology-Head and Neck Surgery, Johns Hopkins, Oct.1985 - Oct. 1991
• Assistant Professor of Neuroscience, Johns Hopkins, Oct.1985 - Oct. 1991
• Assistant Professor of Biomedical Engineering, Johns Hopkins, Dec. 1990 - Oct. 1991

Recent Publications:

• Basura GJ, Abbas AI, O'Donohue H, Lauder JM, Roth BL, Walker PD, Manis PB. Ontogeny of serotonin and serotonin2A receptors in rat auditory cortex. Hear Res. 2008 Oct;244(1-2):45-50. Epub 2008 Aug 6.

• Wang Y, Manis PB. Short-term synaptic depression and recovery at the mature mammalian endbulb of Held synapse in mice. J Neurophysiol. 2008 Sep;100(3):1255-64. Epub 2008 Jul 16.

• Spirou GA, Chirila FV, von Gersdorff H, Manis PB. Heterogeneous Ca2+ influx along the adult calyx of held: a structural and computational study. Neuroscience. 2008 Jun 12;154(1):171-85. Epub 2008 Apr 7.

• Street SE, Manis PB. Action potential timing precision in dorsal cochlear nucleus pyramidal cells. J Neurophysiol. 2007 Jun;97(6):4162-72. Epub 2007 Apr 18.

• Wang Y, Manis PB. Temporal coding by cochlear nucleus bushy cells in DBA/2J mice with early onset hearing loss. J Assoc Res Otolaryngol. 2006 Dec;7(4):412-24. Epub 2006 Oct 26.

• Bortone, D.S., Mitchell, K., and Manis, P.B. Developmental Time Course of Potassium Channel Expression in the Rat Cochlear Nucleus. Hearing Research, 211, 114-125, 2006.

• Spirou, G.A., Rager, J. and Manis, P.B. Convergence of auditory nerve fibers onto globular bushy cells. Neuroscience 136: 843-863, 2005.

• Wang, Y. and Manis, P.B. Synaptic transmission at the cochlear nucleus endbulb synapse during age-related hearing loss in mice. Journal of Neurophysiology, 94 (3): 1814-1824, 2005.

• Kanold, P.O. and Manis, P.B. Encoding the timing of inhibitory inputs. Journal of Neurophysiology, 93:2887-2897, 2005.

• Manis, P.B., Molitor, S.C., Wu, H. Subthreshold oscillations generated by TTX-sensitive sodium currents in dorsal cochlear nucleus pyramidal cells. Experimental Brain Research 153: 443-451, 2003.

• Molitor, S.C. and Manis, P.B. Dendritic Ca2+ transients evoked by action potentials in rat dorsal cochlear nucleus pyramidal and cartwheel neurons. Journal of Neurophysiology 89: 2225-2237, 2003.

• Rothman, J.S. and Manis, P.B. The roles potassium channels play in the electrical activity of ventral cochlear nucleus neurons: a theoretical investigation. Journal of Neurophysiology 89: 3097-3113, 2003.

• Rothman, J.S. and Manis, P.B. Kinetic analyses of three distinct potassium conductances in ventral cochlear nucleus neurons. Journal of Neurophysiology 89: 3083-3096, 2003.

• Rothman, J.S. and Manis, P.B. Differential expression of three distinct potassium conductances in the ventral cochlear nucleus. Journal of Neurophysiology 89: 3070-3082, 2003.