Mark C. Weissler, MD, FACS

Joseph P. Riddle Distinguished Professor of Otolaryngology/Head and Neck Surgery Chief, Division of Head and Neck Oncology Chair of the Board of Regents of the American College of Surgeons Director of the American Board of Otolaryngology

Mark C. Weissler, MD, FACS



Head and Neck Cancer; Laryngeal/Tracheal Stenosis; Oral, Oropharyngeal, Laryngeal and Hypopharyngeal Cancer; Thyroid Cancer; Cancer of the Parotid and Submandibular Glands; Major and Minor Salivary Gland Cancer.

Contact Information

  • Appointment Scheduler: (984) 974-6484

  • Surgery Scheduler: Patricia Longest (919) 966-7491

  • Nurse: Sharon Rubischko (984) 974-3521

  • Administrative Coordinator: Ashton Oliver (919) 966-8927


  • MD: Boston University School of Medicine, Boston, MA, 1980

  • Residency: Massachusetts General Hospital,  Harvard University, Boston, MA, 1980-1982

  • Residency: Massachusetts Eye and Ear Infirmary, Harvard University, MA, 1982-1985

  • Fellowship: Head and Neck Oncology Surgery, University of Cincinnati, 1985-1986

    Professional Experience:

  • Professor and Chief, Division of Head and Neck Oncology, Dept. of Otolaryngology/Head and Neck Surgery, UNC School of Medicine, 2001-present

  • Joseph P. Riddle Distinguished Professor of Otolaryngology, UNC, 2000-present

  • Professor, Div. of Otolaryngology/Head & Neck Surg, Dept. of Surgery, UNC, 1996-2001

  • Associate Professor, Div. Of Otolaryngology/Head & Neck Surgery, Dept. of Surgery, UNC, 1993-1996

  • Assistant Professor, Div. Of Otolaryngology/Head & Neck Surgery, Dept. of Surgery, UNC, 1986-1992

    Recent Honors:

  • Former Chair, Board of Regents, American College of Surgeons

  • Best Doctors in America, 2007-2016 databases

  • America’s Top Doctors recognition for Cancer, published by Castle Connolly Medical Ltd., 2007 - 2016

  • America's Top Doctors recognition for Otolaryngology, published by Castle Connolly Medical, Ltd., 2002 - 2016

    Recent Publications:

    1.         Effect of HPV on head and neck cancer patient survival, by region and tumor site: A comparison of 1362 cases across three continents. D'Souza G, Anantharaman D, Gheit T, Abedi-Ardekani B, Beachler DC, Conway DI, Olshan AF, Wunsch-Filho V, Toporcov TN, Ahrens W, Wisniewski K, Merletti F, Boccia S, Tajara EH, Zevallos JP, Levi JE, Weissler MC, Wright S, Scelo G, Mazul AL, Tommasino M, Brennan P, Cadoni G. Oral Oncol. 2016 Nov;62:20-27. doi: 10.1016/j.oraloncology.2016.09.005. PMID: 27865368

    2.         Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer.  Lesseur C, Diergaarde B, Olshan AF, Wünsch-Filho V, Ness AR, Liu G, Lacko M, Eluf-Neto J, Franceschi S, Lagiou P, Macfarlane GJ, Richiardi L, Boccia S, Polesel J, Kjaerheim K, Zaridze D, Johansson M, Menezes AM, Curado MP, Robinson M, Ahrens W, Canova C, Znaor A, Castellsagué X, Conway DI, Holcátová I, Mates D, Vilensky M, Healy CM, Szeszenia-Dąbrowska N, Fabiánová E, Lissowska J, Grandis JR, Weissler MC, Tajara EH, Nunes FD, de Carvalho MB, Thomas S, Hung RJ, Peters WH, Herrero R, Cadoni G, Bueno-de-Mesquita HB, Steffen A, Agudo A, Shangina O, Xiao X, Gaborieau V, Chabrier A, Anantharaman D, Boffetta P, Amos CI, McKay JD, Brennan P. Nat Genet. 2016 Dec;48(12):1544-1550. doi: 10.1038/ng.3685. PMID: 27749845

    3.         Oral health and human papillomavirus-associated head and neck squamous cell carcinoma.  Mazul AL, Taylor JM, Divaris K, Weissler MC, Brennan P, Anantharaman D, Abedi-Ardekani B, Olshan AF, Zevallos JP. Cancer. 2016 Aug 29. doi: 10.1002/cncr.30312. [Epub ahead of print] PMID: 27571516

    4.         Impact of post-chemoradiotherapy superselective/selective neck dissection on patient reported quality of life.  Wang K, Amdur RJ, Mendenhall WM, Green R, Aumer S, Hackman TG, Zanation AM, Zevallos JP, Patel SN, Weissler MC, Chera BS. Oral Oncol. 2016 Jul;58:21-6. doi: 10.1016/j.oraloncology.2016.04.015. PMID: 27311398

    5.         Factors that impact health-related quality of life over time for individuals with head and neck cancer.  Reeve BB, Cai J, Zhang H, Weissler MC, Wisniewski K, Gross H, Olshan AF. Laryngoscope. 2016 Dec;126(12):2718-2725. doi: 10.1002/lary.26073. PMID: 27224024