|
If you are interested in
participating in this study,
contact our research coordinator using the
information shown below.
Study
number:
|
IRB 05-2547
(formerly 05-PED-1094)
|
Principal
Investigator:
|
Terry
Noah, MD
|
| Description: |
The
purpose of this research study is to learn about how influenza virus
affects
nasal inflammation in people passively or actively exposed to cigarette
smoke.
Subjects will be given a dose of an approved
influenza vaccine called FluMist which is sprayed into the nose.
This vaccine has been shown to effectively
prevent the “flu” in healthy young adults. It does so by creating a
limited
viral infection in the nose, which does not spread to the lungs or give
an
individual the “flu.” The aims of the
research study are to compare how much inflammation occurs in reaction
to the
vaccine in
people who smoke and in nonsmokers passively exposed daily to cigarette
smoke or those not exposed. This
will be done by obtaining a series of “nasal lavages” or rinses of the
nose
with salt water, as well as 2 superficial biopsies of the inside lining
of the nose,
during the period just before and again several weeks after receiving
the
vaccine. Using these samples, we will
measure the amount of virus and the amount of nasal inflammation.
We will assess how much smoke subjects are exposed
to using a questionnaire and by measuring the amount of a tobacco smoke
by-product in subjects’ urine. |
Contact:
|
(919)-966-2879
or email FAMRI-2@med.unc.edu
|
| Requirements: |
- You must be between 18 and
35
- You should be healthy
smoker or nonsmoker and have no chronic illness
- You should not be pregnant
or nursing
- You should not have a
history of egg allergy, Guillain-Barrè syndrome or take aspirin
on a regular basis
|
| Time Commitment: |
Nine visits over 6-8 weeks with visit
duration
ranging from 1-2 hours |
| Compensation: |
Volunteers completing all study procedures
will
be compensated up to $360 |
| Review the
Informed Consent Form: |
IRB
05-2547
informed consent form
|
|
