|
If you are interested in
participating in this study,
contact our research coordinator using the
information shown below.
Study
number:
|
GCRC 2475
|
Principal
Investigator:
|
David
B. Peden, MD
|
Description:
|
The
purpose of this Phase 1 research study is to use a dose of inhaled
endotoxin,
that has proven safe (i.e. does not cause prolonged cough, shortness of
breath
or other problems) in healthy non-smoking individuals, but causes
changes in
certain cells in airways that the scientists can measure in your
sputum.
Changes in these cells may suggest the beginning of a mild response to
endotoxin. Endotoxins
are a type of bacteria and are a
component of cigarette smoke, and we are interested in seeing whether
active
smokers’ cells respond to an inhaled endotoxin challenge. Eventually,
these types of studies will be used to examine why some people are more
sensitive to endotoxin than others. Endotoxin is also a component of
outdoor
air pollution, and is found in high levels in a number of different
workplaces
(cotton mills, poultry farms), and is even found in homes. |
Contact:
|
(919)-962-4247
or email marrt@med.unc.edu
|
| Requirements: |
- You must be between 18 and 40
- You must be a current
smoker, but without signs of smoking related lung disease
- You should not have
asthma or allergies, or
other chronic illness
|
Time
Commitment:
|
4 research lab visits over 2 weeks |
Compensation:
|
Volunteers
completing all
study procedures will be compensated up to $425.00
|
| Review the
Informed Consent Form: |
GCRC 2475 informed
consent form
|
|
