Current Projects

Comparative Effectiveness of Ambulatory Blood Pressure Monitoring vs Usual Care for Diagnosing and Managing Hypertension: A Pilot Study

Kristin-ABPMThe usual strategy for detecting hypertension—repeated office blood pressure (BP) measurements—is inefficient and inaccurate. When paired with ambulatory BP monitoring (ABPM), which takes a multiple measurements over 24 hours, it is clear that office BP measurements may convey a falsely positive diagnosis known as white-coat hypertension. What is less well-known is that office BP measurements may also convey a falsely negative diagnosis termed masked hypertension (MH). That is, office BP may measure as normal, yet 24-hour ambulatory measurements show elevated BP.

The purpose of this study is to compare the effectiveness of standard practice to ABPM for correctly diagnosing and managing hypertension.

This study is currently open to enrollment.

A Pilot Study of Plasma Renin Activity Guided vs. Generic Combination Therapy for Hypertension

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The selection of the initial drug used to treat hypertension as well as the subsequent add-on drug(s) if blood pressure does not come under control is typically based on general recommendations rather than an individual person's characteristics.

Plasma renin is an enzyme in blood that plays a major role in the regulation of hypertension. Measurement of plasma renin activity can be used to clarify hypertension subtype. Determining whether plasma renin activity is high or low may allow us to choose a drug type specific for an individual's hypertension subtype and gain blood pressure control more quickly and with fewer medications.

This research study is being conducted to further investigate the effect of using plasma renin activity (PRA) to guide treatment for hypertension and to examine the feasibility of conducting a similar trial on a larger scale.

Enrollment to this study is complete.

A Pilot Study on Patterns of Ambulatory Intraocular Pressure and Blood Pressure Monitoring in Glaucoma

IOP-EDITEDIncreased intraocular pressure (IOP) is the primary risk factor for development of glaucoma, but individuals with normal IOP can also develop glaucoma.  While current research suggests that correlations do exist between IOP and blood pressure (BP), little is known about the circadian correlations over time, especially at nighttime.

The purpose of this study is to investigate the relationship between IOP and BP in patients with normal tension glaucoma, as well as in healthy volunteers without glaucoma.  To examine this correlation, study participants will wear an ambulatory blood pressure monitor and a single-use contact lens that allow for concurrent measurements of BP and IOP while the participant remains ambulatory, over a period of 24 hours.

Enrollment to this study is complete.

Reproducibility and Clinical Implications of Masked Hypertension

Funded by the National Institute of Health, National Heart, Lung and Blood Institute (NIH-NHLBI)Emily-Cuff-Final

Masked hypertension is a term that refers to blood pressure measurements that are not elevated when measured in the doctor’s office but are elevated over the course of a day when an individual is going about his or her typical daily activities.  It is estimated that about 10% of the adult population has masked hypertension.  Recent data suggest that people with masked hypertension have increased cardiovascular risks similar to individuals with sustained hypertension.  Therefore, it is important that we learn more about masked hypertension to ultimately improve detection and reduce heart attacks and strokes.

This research study is being conducted to further investigate the prevalence of masked hypertension and investigate possible clinical correlations to masked hypertension.

Enrollment to this study is complete.