Shawn Ahmed's group reports on a novel mechanism of gene silencing in Caenorhabditis elegans, termed "multigenerational RNAe"
The title of the article, published in PNAS, is "Lack of pairing during meiosis triggers multigenerational transgene silencing in Caenorhabditis elegans." Co-first authors are Luciana Leopold, a graduate student in the Curriculum in Genetics and Molecular Biology, and Bree Heestand, a postdoctoral fellow in Shawn's lab.
Oliver Smithies Investigator Award recipients are selected based on their sustained excellence in their chosen disciplines, their international reputation as a leader in their fields and the impact of their research within the medical and scientific communities.
Jim was one of four discussants on NPR's "On Point" and coauthor of an editorial in JAMA
Sara Selitsky has first-authored a paper published in Scientific Reports (Nature's open access journal).
The title of the paper is "Small tRNA-derived RNAs are increased and more abundant than microRNAs in chronic hepatitis B and C." Sara is a BCB graduate student who is co-mentored by Praveen Sethupathy and Stan Lemon (Department of Medicine).
Matt Weiser, a graduate student in Terry's lab, is first author on the paper, entitled "Novel Distal eQTL Analysis Demonstrates Effect of Population Genetic Architecture on Detecting and Interpreting Associations."
Shawn Ahmed and colleagues publish a paper in PNAS demonstrating a novel function of two C. elegans RNA interference proteins
Shawn and Eric Miska at the University of Cambridge are senior authors on the paper, and Shawn's former postdoc, Aisa Sakaguchi, and former graduate student, Matt Simon, as co-first authors with Peter Sarkies from Dr. Miska's lab.
Fernando Pardo-Manuel de Villena has been elected to the Board of Directors of the Genetics Society of America (GSA).
Fernando will serve a three-year term beginning January 1, 2015.
Yun Li, Karen Mohlke, and Chuck Perou are among the top 1% most cited world researchers in their subject fields for 2014.
Evans and Perou are quoted regarding the risks of reporting germline mutations in numerous genes implicated in rare forms of hereditary predispositions to breast cancer.
The Perspective is entitled "Genetics Driving Epigenetics."
Dr. Sharpless succeeds H. Shelton “Shelley” Earp, MD, as center director effective January 1, 2014.
In collaboration with groups at three other institutions, they identified different miRNAs that are critical "regulatory hubs" in the immune response to the parasites Leishmania major and Schistosoma mansoni.
Chuck has been honored with the 2013 Hyman L. Battle Distinguished Cancer Research Award in recognition of his accomplishments in cancer research.
A research article highlights a method for prioritizing variants in miRNAs by their functional significance. Two Thematic Reviews are included in a special section of the Journal of Lipid Research.
The article by Jim Evans discusses the importance of the involvement of knowledgeable health care providers in communicating complex genomic information to patients and research subjects.
Triangle Business Journal on Tuesday unveiled 29 finalists for its 2013 Health Care Heroes Awards. Chuck and colleagues have also recently published an article in The Oncologist
Karen Mohlke is corresponding author on a paper reporting low-frequency variants in three new genes associated with abnormal insulin production or processing.
Ned Sharpless and colleagues have developed a mouse model that makes it possible to visualize tumor growth by means of a "knocked-in" p16 gene linked to a luciferase reporter.
An investigation into diabetes-related outcomes in a rat model, with senior author William Valdar, PhD, assistant professor of genetics at UNC, and first author Leah Solberg Woods, PhD, from the Medical College of Wisconsin, has made the editor's pick in this month's Physiological Genomics, a journal of the American Physiological Society.
Title of the paper is "MicroRNA-27b is a regulatory hub in lipid metabolism and is altered in dyslipidemia," published in the February 2013 issue.