Key words: non-coding RNAs, gene regulation, functional genomics, computational biology, diabetes and cancer
We focus on the study of regulatory RNAs (such as microRNAs) and their functions in the liver and intestine, particularly as it pertains to: (1) the adaptive host response to environmental perturbation and (2) the molecular etiology of complex diseases, with active projects on diabetes, hyperlipidemia, liver cancer, and inflammatory bowel diseases.
- the contribution of microRNA networks to gene expression dynamics
- microRNA mediated regulation of lipid homeostasis and insulin sensitivity
- dietary and microbial control of microRNAs that regulate intestinal epithelial cell function
- microRNA and whole transcriptome analyses of liver diseases, including cancers.
- microRNAs and tRNA-derived RNAs as biomarkers of disease
- and novel forms of intercellular communication via regulated transfer of small RNAs
Our laboratory research paradigm is highly interdisciplinary, at the interface of computational and experimental biology. The lab members have expertise and interest in diverse areas of study, including functional genomics, gene regulation, molecular biology, bioinformatics, and human genetics.