Gene Symbol

Gene Name

Chromosome

ES Cell Line

Targeting Construct

Phenotype

Andrews HN, Mullan PB, McWilliams S, Sebelova S, Quinn JE, Gilmore PM,
McCabe N, Pace A, Koller B, Johnston PG, Haber DA, Harkin DP. BRCA1 regulates the interferon gamma-mediated apoptotic response. J Biol Chem. 2002 Jul 19;277(29):26225-32.

Aprelikova O, Pace AJ, Fang B, Koller BH, Liu ET. BRCA1 is a selective co-activator of 14-3-3 sigma gene transcription in mouse embryonic stem cells. J Biol Chem. 2001 Jul 13;276(28):25647-50.

Bennett LM, McAllister KA, Malphurs J, Ward T, Collins NK, Seely JC, Gowen
LC, Koller BH, Davis BJ, Wiseman RW. Mice heterozygous for a Brca1 or Brca2 mutation display distinct mammary gland and ovarian phenotypes in response to diethylstilbestrol. Cancer Res. 2000 Jul 1;60(13):3461-9.

Bhattacharyya A, Ear US, Koller BH, Weichselbaum RR, Bishop DK. The breast cancer susceptibility gene BRCA1 is required for subnuclear assembly
of Rad51 and survival following treatment with the DNA cross-linking agent
cisplatin. J Biol Chem. 2000 Aug 4;275(31):23899-903.

Snouwaert JN, Gowen LC, Latour AM, Mohn AR, Xiao A, DiBiase L, Koller BH. BRCA1 deficient embryonic stem cells display a decreased homologous
recombination frequency and an increased frequency of non-homologous
recombination that is corrected by expression of a brca1 transgene. Oncogene. 1999 Dec 20;18(55):7900-7.

Moynahan ME, Chiu JW, Koller BH, Jasin M. Brca1 controls homology-directed DNA repair. Mol Cell. 1999 Oct;4(4):511-8.

Cressman VL, Backlund DC, Avrutskaya AV, Leadon SA, Godfrey V, Koller BH. Growth retardation, DNA repair defects, and lack of spermatogenesis in
BRCA1-deficient mice. Mol Cell Biol. 1999 Oct;19(10):7061-75.

Cressman VL, Backlund DC, Hicks EM, Gowen LC, Godfrey V, Koller BH.
Mammary tumor formation in p53- and BRCA1-deficient mice. Cell Growth Differ. 1999 Jan;10(1):1-10.

Gowen LC, Avrutskaya AV, Latour AM, Koller BH, Leadon SA. BRCA1 required for transcription-coupled repair of oxidative DNA damage. Science. 1998 Aug 14;281(5379):1009-12.

Gowen LC, Johnson BL, Latour AM, Sulik KK, Koller BH. Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities.
Nat Genet. 1996 Feb;12(2):191-4.