Gene Symbol

Gene Name

Chromosome

ES Cell Line

Targeting Construct

Phenotype

Nguyen M, Solle M, Audoly LP, Tilley SL, Stock JL, McNeish JD, Coffman TM, Dombrowicz D, Koller BH. Receptors and signaling mechanisms required for prostaglandin E2-mediated regulation of mast cell degranulation and IL-6 production. J Immunol. 2002 Oct 15;169(8):4586-93.

Nataraj C, Thomas DW, Tilley SL, Nguyen MT, Mannon R, Koller BH, Coffman TM. Receptors for prostaglandin E(2) that regulate cellular immune responses in the mouse. J Clin Invest. 2001 Oct;108(8):1229-35.

Fabre JE, Nguyen M, Athirakul K, Coggins K, McNeish JD, Austin S, Parise LK, FitzGerald GA, Coffman TM, Koller BH. Activation of the murine EP3 receptor for PGE2 inhibits cAMP production and promotes platelet aggregation.
J Clin Invest. 2001 Mar;107(5):603-10.

Audoly LP, Tilley SL, Goulet J, Key M, Nguyen M, Stock JL, McNeish JD,
Koller BH, Coffman TM. Identification of specific EP receptors responsible for the hemodynamic effects of PGE2. Am J Physiol. 1999 Sep;277(3 Pt 2):H924-30.

Fleming EF, Athirakul K, Oliverio MI, Key M, Goulet J, Koller BH, Coffman
TM. Urinary concentrating function in mice lacking EP3 receptors for prostaglandin E2. Am J Physiol. 1998 Dec;275(6 Pt 2):F955-61.

Nguyen M, Camenisch T, Snouwaert JN, Hicks E, Coffman TM, Anderson PA,
Malouf NN, Koller BH. The prostaglandin receptor EP4 triggers remodelling of the cardiovascular system at birth. Nature. 1997 Nov 6;390(6655):78-81.