Gene Symbol

 Grin1

Gene Name

Glutamine N-methyl-D-aspartate (NMDA) receptor
subunit zeta 1 (NR1)

Chromosome

 2
Celera ID
Ensembl ID
 mCG13006
ENSMUSG00000026959

ES Cell Line

 E14TG2a
 
PCR Primers




 

Phenotype

 

These mice are deficient in NMDA receptors, but express sufficient levels (5%-10% of wild type levels) to allow for survival until adulthood. Mice completely lacking the NR1 protein die perinatally. NR1 (-/-) mice exhibit behavioral abnormalities that are associated with schizophrenia. These behaviors are improved by the antipsychotic drugs haloperidol and clozapine.



 

 

 

 

 

 

 

 

 

 

 

 

 

Related Publications

Duncan G, Miyamoto S, Gu H, Lieberman J, Koller B, Snouwaert J. Alterations in regional brain metabolism in genetic and pharmacological models of reduced NMDA receptor function. Brain Res. 2002 Oct 4;951(2):166-76.

Mohn AR, Gainetdinov RR, Caron MG, Koller BH. Mice with reduced NMDA receptor expression display behaviors related to schizophrenia. Cell. 1999 Aug 20;98(4):427-36.