Area of Interest:
I am a biochemist and protein chemist working in the field of coagulation. The primary area on which we have worked involves control mechanisms for coagulation. Initially we studied individual coagulation reactions, specifically factor IXa structure and function, and have continued that work through the years. But, in an effort to better understand therapeutics for hemophilia, the work on single factors evolved into a study of the complex interactions between the coagulation factors leading to our development of what has been called the Cell Based Model of coagulation. While our in vitro studies were very successful and helped define the mechanism of high dose factor VIIa as a therapy for hemophilia, it became clear that we needed to translate that work into studies on physiology. Thus we developed the bleeding, wound healing, and thrombosis models that we currently use in the lab. The bleeding model has enabled us and others to study the effects of different therapeutics in hemophilia and in drug induced bleeding. The wound healing model has let us study the hemostatic effect of novel anti-hemophilic therapeutics designed to have a long half-life.
Awards and Honors:
- Special Projects Award - Bayer Hemophilia Awards Program sponsored by Bayer Pharmaceuticals. May 2006.
- Program Committee Chair - Hemophilia Care in the New Millennium: An International Symposium in Honor of Dr. Harold R. Roberts. 1999
- Young Investigator Award - The XIIth Congress of the International Society on Thrombosis and Haemostasis. 1989