Publications

Published work in collaboration with the UNC-Human Pluripotent Stem Cell Core:

Human Embryonic Stem Cells Have Constitutively Active Bax at the Golgi and Are Primed to Undergo Rapid Apoptosis.
Dumitru R, Gama V, Fagan BM, Bower JJ, Swahari V, Pevny LH, Deshmukh M.
Mol Cell. 2012 May 2.

Viral single-strand DNA induces p53-dependent apoptosis in human embryonic stem cells.
Hirsch ML, Fagan BM, Dumitru R, Bower JJ, Yadav S, Porteus MH, Pevny LH, Samulski RJ.
PLoS One.
2011; 6(11).

Landmark papers on human iPS cells and hES cells biology:

Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors.
Kazutoshi Takahashi, Koji Tanabe, Mari Ohnuki, Megumi Narita, Tomoko Ichisaka, Kiichiro Tomoda, Shinya Yamanaka.
Cell, Volume 131, Issue 5, 30 November 2007, Pages 861-872.

Disease-Specific Induced Pluripotent Stem Cells.
In-Hyun Park, Natasha Arora, Hongguang Huo, Nimet Maherali, Tim Ahfeldt, Akiko Shimamura, M. William Lensch, Chad Cowan, Konrad Hochedlinger, George Q. Daley.
Cell, Volume 134, Issue 5, 5 September 2008, Pages 877-886

Oct4-Induced Pluripotency in Adult Neural Stem Cells.
Jeong Beom Kim, Vittorio Sebastiano, Guangming Wu, Marcos J. Araúzo-Bravo, Philipp Sasse, Luca Gentile, Kinarm Ko, David Ruau, Mathias Ehrich, Dirk van den Boom, Johann Meyer, Karin Hübner, Christof Bernemann, Claudia Ortmeier, Martin Zenke, Bernd K. Fleischmann, Holm Zaehres, Hans R. Schöler
Cell
, Volume 136, Issue 3, 6 February 2009, Pages 411-419.

Parkinson's Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors.
Frank Soldner, Dirk Hockemeyer, Caroline Beard, Qing Gao, George W. Bell, Elizabeth G. Cook, Gunnar Hargus, Alexandra Blak, Oliver Cooper, Maisam Mitalipova, Ole Isacson, Rudolf Jaenisch.
Cell
, Volume 136, Issue 5, 6 March 2009, Pages 964-977.

Generation of induced pluripotent stem cells from human terminally differentiated circulating T cells.
T. Seki, S. Yuasa, M. Oda, T. Egashira, K. Yae, D. Kusumoto, H. Nakata, S. Tohyama, H. Hashimoto, M. Kodaira et al.
Cell Stem Cell, 7 (2010), pp. 11–14

Reprogramming of Human Peripheral Blood Cells to Induced Pluripotent Stem Cells.
Judith Staerk, Meelad M. Dawlaty, Qing Gao, Dorothea Maetzel, Jacob Hanna, Cesar A. Sommer, Gustavo Mostoslavsky, Rudolf Jaenisch.
Cell Stem Cell, Volume 7, Issue 1, 2 July 2010, Pages 20-24.

A Model for Neural Development and Treatment of Rett Syndrome Using Human Induced Pluripotent Stem Cells.
Maria C.N. Marchetto, Cassiano Carromeu, Allan Acab, Diana Yu, Gene W. Yeo, Yangling Mu, Gong Chen, Fred H. Gage, Alysson R. Muotri
Cell, Volume 143, Issue 4, 12 November 2010, Pages 527-539.

Reference Maps of Human ES and iPS Cell Variation Enable High-Throughput Characterization of Pluripotent Cell Lines.
Christoph Bock, Evangelos Kiskinis, Griet Verstappen, Hongcang Gu, Gabriella Boulting, Zachary D. Smith, Michael Ziller, Gist F. Croft, Mackenzie W. Amoroso, Derek H. Oakley, Andreas Gnirke, Kevin Eggan, Alexander Meissner.
Cell, Volume 144, Issue 3, 4 February 2011, Pages 439-452.

Glis1, a unique pro-reprogramming factor, may facilitate clinical applications of iPSC technology.
Maekawa M, Yamanaka S.
Cell Cycle. 2011 Nov 1; 10(21):3613-4.

Direct reprogramming of somatic cells is promoted by maternal transcription factor Glis1.
Maekawa M, Yamaguchi K, Nakamura T, Shibukawa R, Kodanaka I, Ichisaka T, Kawamura Y, Mochizuki H, Goshima N, Yamanaka S.
Nature. 2011 Jun 8; 474(7350):225-9.

A more efficient method to generate integration-free human iPS cells.
Okita K, Matsumura Y, Sato Y, Okada A, Morizane A, Okamoto S, Hong H, Nakagawa M, Tanabe K, Tezuka K, Shibata T, Kunisada T, Takahashi M, Takahashi J, Saji H, Yamanaka S.
Nat Methods. 2011 May; 8(5):409-12.

Phosphorylation regulates human OCT4.
Brumbaugh J, Hou Z, Russell JD, Howden SE, Yu P, Ledvina AR, Coon JJ, Thomson JA.
Proc Natl Acad Sci
U S A. 2012 May 8;109(19):7162-8.

Thermal stability of fibroblast growth factor protein is a determinant factor in regulating self-renewal, differentiation, and reprogramming in human pluripotent stem cells.
Chen G, Gulbranson DR, Yu P, Hou Z, Thomson JA.
Stem Cells
. 2012 Apr; 30(4):623-30.

Protein kinase C mediated extraembryonic endoderm differentiation of human embryonic stem cells.
Feng X, Zhang J, Smuga-Otto K, Tian S, Yu J, Stewart R, Thomson JA.
Stem Cells
. 2012 Mar; 30(3):461-70.

Optic vesicle-like structures derived from human pluripotent stem cells facilitate a customized approach to retinal disease treatment.
Meyer JS, Howden SE, Wallace KA, Verhoeven AD, Wright LS, Capowski EE, Pinilla I, Martin JM, Tian S, Stewart R, Pattnaik B, Thomson JA, Gamm DM.
Stem Cells
. 2011 Aug;29(8).

Chemically defined conditions for human iPSC derivation and culture.
Chen G, Gulbranson DR, Hou Z, Bolin JM, Ruotti V, Probasco MD, Smuga-Otto K, Howden SE, Diol NR, Propson NE, Wagner R, Lee GO, Antosiewicz-Bourget J, Teng JM, Thomson JA.
Nat Methods.
2011 May;8(5):424-9.