Pharmacokinetic/Laboratory Studies

IRB 15-2767: The Compartmental Biology of HIV in the Male Genital Tract

Question: To better understand the pharmacoloty of antiretroviral therapy (ART) in the male genital tract, to study virus shed in spite of treatment, and the conditions (factors) in semen that appear to permit HIV detection. We hope these results will determine the basis for "residual shedding"

Population: Male volunteers between ages 18-60, inclusive, on tenofovir/emtricitabine for treatment OR prevention

Medication: NONE

Duration: Screening within 42 days of enrollment; One 48-hour inpatient visit where 6 paired blood and semen samples will be collected

Call: Heather Prince, PA-C 919-962-5344

Status: On-going / Recruiting

IRB 16-0398: Measuring Adherence in Hair

Question: We will investigate the influence of race, hair color and hair treatment on ARV response with infra-red (IR)-matrix-assisted laser desorption electrospray ionization (MALDESI) imaging, and evaluate sample pre-treatment or extraction to obtain a standardized response from MSI of hair strands.

Population: Male of female volunteers adherent to regimens including maraviroc, dolutegravir, or tenofovir/emtricitabine

Medication: NONE

Duration: One hair sample collection

Call: Heather Prince, PA-C 919-962-5344

Status: On-going / Recruiting