Friday ID Conference: "Selection and antibody susceptibility during heterosexual HIV-1 transmission"

Manish Sagar, MD

When Feb 10, 2012
from 08:30 AM to 09:30 AM
Where 1131 Bioinformatics
Contact Name
Contact Phone (919) 966-2536
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Manish Sagar, MD, is Assistant Professor of Medicine at Harvard University. Dr. Sagar's research is focused on understanding the pathogenesis of HIV-1 transmission. It has been shown that from a chronically infected host with a wide variety of viruses, only a small number of variants are transmitted to a newly infected subject. Transmission does not occur in a random manner, but rather specific variants are selected for transmission.

His lab is working on deciphering the viral genotypes and phenotypes that are selected during transmission. They have defined sequences in the virus envelope gene that are associated with viruses found early after heterosexual transmission. They are examining whether these signature envelope genotypes are also selectively chosen during other forms of HIV-1 transmission.

In addition, they are beginning to examine how the specific envelope sequences found early in infection confer an advantage during transmission. These studies will increase our understanding of early host cell-virus interactions, which will help in the designing rational strategies to prevent HIV-1 transmission.


Refreshments will be served.


About Friday ID Conference

The Division of Infectious Diseases, Institute for Global Health & Infectious Diseases, and Center for AIDS Research at UNC co-sponsor a weekly conference series which features distinguished clinicians and scientists from UNC, local universities, and other national and international institutions. The topics are varied and appeal to not only infectious disease specialists, but also professionals in epidemiology, public health, microbiology, biostatistics and other global health-related disciplines.

The conference takes place every Friday, September through June, from 8:30-9:30 a.m. in 1131 Bioinformatics (first floor auditorium) on the UNC campus. For more information, or to suggest a speaker, please contact the conference coordinator, Kathy James.

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