Poster Discussions During Networking Group Meetings

Pediatric/CF

P-101 Surfactant Aerosol Treatment Of Preterm Lambs With Severe Respiratory Distress Syndrome.

X Murgia1, V Mielgo1, A Valls-i-Soler2, E Ruiz-del-Yerro1, P Serna1 and C Rey-Santano1
1
Research Unit of Experimental Physiology, Cruces University Hospital, Bilbao, Spain
2
Neonatal Unit, Cruces University Hospital, Bilbao, Spain

P-105 Estimating Deposition Of Respiratory Aerosols From Inhalers In School Age Children Using An Idealized Child Extrathoracic Geometry.

CA Ruzycki1, L Golshahi1, WH Finlay1
1
University of Alberta, Edmonton, AB, Canada

P-108 Evaluation Of A Breath Synchronized pMDI In Children With Asthma Aged 3-11 Years.

AP Bosco1, L Bertucci2, J Burchell2 , K Trimble1, TL Alfredson1, S Devadason2
1
MAP Pharmaceuticals, Inc; Mountain View, CA, USA
2
University of Western Australia; Perth, WA, AUS


Regulatory

P-034 Investigation Of Excipient Properties On Output Rates In A Vibrating Mesh Nebulizer.

S Cullen1, A Hibbitts1, Lidia Tajber3, R MacLoughlin2, SA Cryan1
1
School of Pharmacy, Royal College of Surgeons in Ireland, Dublin, Ireland
2
Aerogen Ltd. Galway Business Park, Galway, Ireland
3
School of Pharmacy, Trinity College Dublin, Ireland

P-049 In-Vitro Dose Comparison Of Respimat® Soft Mist Inhaler™ With Dry Powder Inhalers For COPD Maintenance Therapy.

AM Ciciliani1, P Langguth1, D Bickmann2, H Wachtel2, T Voshaar3
1
Institute of Pharmacy and Biochemistry, J Gutenberg University, MAINZ, Germany
2
Boehringer Ingelheim, Ingelheim, Germany
3
Dept of Pneumology and Allergy, Medical Clinic III, Bethanien Hospital, Moers, Germany

P-109 Development And Initial Validation Of The Child Aerosol Delivery To Anatomical Model (ADAM-III).

JP Mitchell1, M Nuttall1, M Limbrick1, C Doyle1, V Wang1, B Chronik2, DW Holdsworth3, J Milner3

1Trudell Medical International (TMI), London, ON, Canada
2Western University, London, ON, Canada
3
Robarts Research Institute, London, ON, Canada

P-110 Development Of An In-Vitro Test Method For Dissolution Of Inhaled Corticosteroids.

S Bhagwat1, M Rohrschneider2, S Alfadehl1, G Hochhaus1

1University of Florida, Gainesville, FL, United States of America.
2
Boehringer Ingelheim Pharma GmbH & Co. KG, Germany.

P-111 Evaluation Of The Feasibility Of Pharmacodynamic Bioequivalence Studies Of Inhaled Corticosteroids Through Monte Carlo Simulations.

B Kandala1, B Weber1, L Winner2, G Hochhaus1

1Department of Pharmaceutics, University of Florida, Gainesville, FL, USA
2
Department of Statistics, University of Florida, Gainesville, FL, USA


New Devices and Emerging Therapies

P-070 Impact Of MMAD, Acoustic Airflow And Breathing Patterns On Intrasinus Drug Deposition In A Realistic Nasal Cast.

L Leclerc1, J Pourchez1, G Aubert1, L Vecellio2, M Durand1,3
1
LINA, EA 4624, CIS-EMSE, F-42023, Saint-Etienne, France
2
INSERM U1100-EA6305, DTF Aerodrug, Tours, France
3Centre Hospitalier Emile Roux, F-43012, Le Puy en Velay, France

P-072 An Open-Label Randomized Pilot Trial To Evaluate Tolerability, Safety And Applicability Of Budesonide Inhalation Suspension (BIS) Delivered Via AKITA JET In Children Aged 3-11 Years With Mild To Moderate Asthma.

JG Mainz1, S Canisius2, G Scheuch2, B Müllinger2, K Nocker2, T Hofmann2
1
University Hospital Jena, Dept. for Pediatric Pulmonology, Jena, Germany
2
Activaero GmbH, Gemuenden/Wohra, Germany

P-076 Targeted siRNA Delivery To Activated T Cells For Anti-Inflammatory Therapy Of Asthma.

NH Kim1, D Batton1, A Thakur1,2, L Lum1,2, DP Bassett1, OM Merkel1,2
1
Wayne State University, DETROIT, MI, United States of America
2
Karmanos Cancer Institute, DETROIT, MI, United States of America

P-090 Generation Of Respirable Antibody Aerosols.

DB Yeates
KAER Biotherapeutics, Escondido, CA United States of America

P-095 Acute Hyperkalemia Associated With Inhalation Of A Potent ENAC Inhibitor.

TG O’Riordan1, KH Donn2, P Hodsman3, JH Ansede2, T Newcomb1, S Lewis1, WD Flitter1, VS White1, MR Johnson2, AB Montgomery4, DG Warnock5, RC Boucher6
1
Gilead Sciences Inc., Seattle, WA, United States of America
2Parion Sciences Inc., Durham, NC, United States of America
3
Nucleus Network, Ltd., Melbourne, Australia
4
Cardeas Pharma, Seattle, WA, United States of America
5
Division of Nephrology, University of Alabama at Birmingham, Birmingham, AL, United States of America
6Division of Pulmonary and Critical Care Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America

P-097 Aerosol Performance Of Spray Dried MMI-0100 From The Microdose Inhaler For Treatment Of Pulmonary Fibrosis.

D Becker1, C Oakum1, E Reynolds1, R Cook1, A Kirkpatrick1, P. Arensdorf2, C. Lander2, A. Panitch2, C. Peterson2
1
MicroDose Therapeutx, Monmouth Junction, NJ, United States of America
2
Moerae Matrix, Morristown, NJ, United States of America

Environmental/Occupational Health/Toxicology

P-115 Surfactant Interactions With Sub-Micron Particles: The Importance Of Route Of Exposure.

AM Farnoud1, J Fiegel1
1
University of Iowa, Iowa City, IA, United States of America

P-120 Respiratory Source Control: Key To Controlling Airborne Infection.

Rajeev B. Patel, MD, Mohamed M. Mansour, MD, Shaji Skaria, MD and Gerald C. Smaldone, MD, PhD
Stony Brook University Medical Center, State University of New York, Stony Brook, NY

P-124 Deposition Of Fractal-Like Aggregates In A Cast Of Human Lung Airways Under Various Breathing Conditions.

A Penconek, M Odziomek, A Moskal
Warsaw University of Technology, Department of Chemical and Process Engineering, Warsaw, Poland

P-125 Effects Of Secondary Organic Aerosols From Gasoline Exhaust On Healthy And Diseased Respiratory Epithelia.

L Künzi1, J Dommen2, N Daher3, M Krapf2, S Schneider1, N Jeannet1, S Platt2, J Slowik2, ASH Prévôt2, M Kalberer4, U Baltensperger2, C Sioutas3, M Geiser1
1
Institute of Anatomy, University of Bern, Bern, Switzerland
2Laboratory of Atmospheric Chemistry, Paul Scherrer Institute, Villigen, Switzerland
3Department of Civil and Environmental Engineering, University of Southern California, Los Angeles, CA United States of America
4Department of Chemistry, University of Cambridge, Cambridge, United Kingdom


Imaging, Modeling, and Physiology of Aerosols in the Lung

P-015 Comparison Of Numerical Simulation To Experiments For A Jet Nebulizer.

N. Lelong1,5, L. Vecellio1,5, Y. Sommer de Gelicourt3, C. Tanguy4, P. Diot5, H. Suzanne2, A. Junqua-Moullet2
1DTF-Aerodrug, Faculté de Médecine, F-37032 Tours, France
2
CEA Le Ripault, F-37260 Monts, France
3
ANSYS France, F-78180 Montigny Le Bretonneux, France
4
Dantec Dynamics, F-91620 Nozay, France
5Centre d'Etude des Pathologies Respiratoires INSERM U1100/EA6305, Université François Rabelais de Tours, Faculté de Médecine, F-37032 Tours, France

P-027 Comparison Of 2D Planar Gamma Camera And 3D SPECT Measurements With 1D Simulation Results Of Aerosol Deposition In Healthy Humans.

M Pichelin1, IM Katz1,2, C Majoral1, S Montesantos1, C Dubau1, J Fleming3,4, M Bennett3, J Conway3,5, G Caillibotte2
1
Medical Gases Group, Air Liquide Santé International, Les Loges-En-Josas, France
2
Lafayette College, Easton, PA, United States of America
3National Institute of Health Research Biomedical Research Unit in Respiratory Disease, Southampton, UK
4Department of Medical Physics and Bioengineering, University Hospital Southampton NHS Foundation Trust, Southampton, UK
5Faculty of Health Sciences, University of Southampton, Southampton, UK

P-032 Lung Deposition Of 99mTc-Salbutamol From A Pressurized Metered Dose Inhaler And A Valved Holding Chamber, Used With Facemask Or Mouthpiece In Children With Stable Asthma- A Pilot Study.

J Murdzoska1; W Ditcham1; C Roller1; D von Hollen2; K Nikander2; S Devadason1
1
School of Paediatrics and Child Health, University of Western Australia, Perth, W.A., Australia.
2
Philips Respironics, Respironics New Jersey, Inc., Parsippany, NJ, USA.

P-040 Relationship Between Regional Ventilation And Aerosol Deposition In Bronchoconstricted Subjects With Asthma.

EE Greenblatt1, RS Harris2, T Winkler2, VJ Kelly2, M Kone2, I Katz3, A Martin3, G Caillibotte3, JG Venegas2
1
Massachusetts Institute of Technology and Massachusetts General Hospital, Boston, MA, USA
2Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
3Air Liquide R&D, Joy En Josas, France

P-044 Spatial Distribution Of Aerosols In Healthy Rat Lungs: Findings From Numerical And Experimental Models.

JM Oakes1, C Darquenne2, Celine Grandmont4, Miriam Scadeng3, Ellen Breen2, I Vignon-Clementel4, AL Marsden1
1,2,3Dept. of Mechanical and Aerospace Engineering1, Medicine2 and Radiology3, University of California at San Diego, La Jolla, CA, USA
4
INRIA, Paris-Roquencourt, Le Chesnay Cedex, France