Contact Activation
July 19, 2002
9:00 to 13:00
Stanbro Room
The Boston Park Plaza Hotel
Chairman: R. A. DeLa Cadena, USA.
Co-Chairs; A. H. Schmaier, USA; I. Schousboe, Denmark; H. Saito, Japan;
M. J. Gallimore, UK; Keith R. McCrae, USA; A. Zivelin, Israel
The meeting was well attended with approximately 50 people in the room.
The Chair introduced the Co-Chairs present in the room and acknowledged the
list of individuals who were listed in the program. The Chair in turn communicated
with the audience the message from Dr. Francis, namely the mission of the
Subcommittee including new methods, new topics, predictive values and standardization
of plasma samples for contact factors.
The session started with the first presentation by Dr. Pixley entitled "Genetic
alterations of high molecular weight kininogen modulates inflammation" and
then followed by other speakers listed below.
- Antibodies Directed Against Factor XII and Recurrent Fetal Loss (Dr.
Wynne Jones)
- Antiphospholipid Murine Antibodies that Cross-react with HK and TSP1.(Dr.
Marc Monestier)
- Plasma Prekallikrein Activation on Endothelial Cells: Reality or Illusion
(Dr. Zia Shariat – Madar)
- DX-88, A novel Therapeutic Peptide Inhibitor of Kallikrein (Dr. Ian
Mackie)
All presentations were highly focused and methodological in nature.
A full sixty (60) minutes were devoted to issues related to:
- Standardization Procedures: Including the Prekallikrein Activator
that has been available since 1982 and that Dr. Pixley at Temple University
School of Medicine will compare to two other commercially available plasmas.
Dr. Schmaier’s laboratory will examine by Western blotting technique the
plasma stocks available from the ISTH. It was emphasized by Dr. Schmaier
that "no preparation seems to be suitable for the 'so called' Contact System".
Dr. Gallimore reminded everyone that a few years ago standardization of plasma
required at least twenty (20) laboratories to test the samples. A question
was raised about being able today to get twenty (20) laboratories to participate.
- Re-naming of the Subcommittee was discussed with two suggestions from
the floor. One from Dr. Schmaier, namely " Kallikrein-Kinin System" and the
second one from Dr. Pixley entitled "Kininogen Dependent Systems". The Chair
then encouraged everyone to be vocal with suggestions and to pass the word
and to ask colleagues for suggestions. The Chair and Co-Chairs in turn will
research at the SSC Business Meeting the mechanism for the change of a Subcommittee
name.
1. - Continue the mission of the Subcommittee.
2. - New Methods.
3. - Animal Models.
4. - Predictive Values.
Respectfully prepared by Dr. DeLa Cadena