Platelet Physiology

7 August 2005
8:30 to 12:00
Tumbalong Meeting Room
Sydney Convention and Exhibition Centre

Chairman:  A. Michelson, USA
Co-chairs:  J. Bennett, USA; M. Cattaneo, Italy; C. Cerletti, Italy; C. Hayward, Canada; D. Kenny, Ireland;
J. Lopez, USA; D. Nugent, USA; P. Nurden, France; A. Koneti Rao, USA; S. Watson, UK

This year’s Platelet Physiology Subcommittee Program in Sydney Australia was divided into 3 parts:

1. Aspirin and Clopidogrel Resistance (co-chairs Alan Michelson and Marco Cattaneo)

Dr. Alan Michelson (U.S.A.) spoke on “Platelet Response Variability to Aspirin And Clopidogrel” and Dr. Diane Nugent (U.S.A.) spoke on “ Evaluation Of Platelet Response To Aspirin And Clopidogrel”. A general discussion followed. The Working Party on Aspirin Resistance (Chair: Alan Michelson) has just published (June 2005) an official communication of the SSC: Michelson AD, Cattaneo M, Eikelboom JW, Gurbel P, Kottke-Marchant K, Kunicki TJ, Pulcinelli M, Cerletti C, Rao AK. Aspirin Resistance: position paper of the Working Group on Aspirin Resistance. Journal of Thrombosis and Haemostasis 2005:3:1309-1311. A future official communication of the SSC on the subject of clopidogrel “resistance” is planned.

2. Inherited Thrombocytopenias (co-chairs Alan Michelson and Paquita Nurden)

Dr. Carlo Balduini ( Italy ) spoke on "Classification Of Inherited Thrombocytopenias", Dr. Catherine Hayward ( Canada ) spoke on "Clinical Challenges With Assessing Inherited Platelet Disorders Associated With Thrombocytopenia”, and Dr. Amy Geddis (U.S.A.) spoke on “A Registry And Shared Resource For Congenital Thrombocytopenias”. A general discussion followed. Drs. Amy Geddis and Jim Bussel have set up a Non-immune Thrombocytopenia Registry.

3. The Platelet Transcriptome (co-chairs Willem Ouwehand and Koneti Rao)

Dr. Willem Ouwehand (United Kingdom), on behalf of the Bloodomics consortium, spoke on “Transcription Profiling In Human Megakaryocytes And Platelets With The Aim To Discover Novel Genetic Markers For The Prediction Of Thrombus Formation”, Dr. Andrew Weyrich (U.S.A.) spoke on “ Mixed Messages: Are Platelet RNAs Important for Cellular Function?”, Dr. Wadie Bahou (U.S.A.) spoke on “ Progress And Limitations Of Platelet Transcript Profiling”, Dr. Koneti Rao (U.S.A.) spoke on “ Expression Profiling In Platelet Function Disorders”, and Dr. Dermot Kenny ( Ireland) spoke on “ Translating The Platelet Transcriptome” . A general discussion followed. The Working Party on the Platelet Proteome (Chair: Steve Watson) has just published an official communication of the SSC: Watson SP, Bahou WF, Fitzgerald D, Ouwehand W, Rao AD, Leavitt AD. Mapping the platelet proteome: a report of the ISTH Platelet Physiology Subcommittee. Journal of Thrombosis and Haemostasis 2005; early edition online. A future official communication of the SSC on the subject of the platelet transcriptome is planned.

In addition to those listed above, the following manuscript is undergoing SSC review prior to submission to the Journal of Thrombosis and Haemostasis as an official communication of the SSC: Hayward CPM, Harrison P, Cattaneo M, Ortel TL, Rao AK. Closure time in the evaluation of platelet disorders and platelet function: a report of the Working Party on the PFA-100.

Working Parties of the SSC Platelet Physiology Subcommittee:

• Platelet Proteome
• Chair: Steve Watson
• Members: Wadie Bahou, Desmond Fitzgerald, Andrew Leavitt, Willem Ouwehand, Koneti Rao
• Platelet Transcriptome
• Chair: Willem Ouwehand
• Members: Wadie Bahou, Dermot Kenny, Koneti Rao, Steve Watson, Andrew Weyrich
• Evaluation of Platelet Function Disorders
• Chairs: Marco Cattaneo, Cathy Hayward, Koneti Rao
• Members: Carlo Balduini, Amy Geddis, Alan Michelson, Diane Nugent, Paquita Nurden, Koneti Rao, Steve Watson
• Aspirin Resistance
• Chair: Alan Michelson
• Members: Marco Cattaneo, Chiara Cerletti, John Eikelboom, Paul Gu rbel, Kandice Kottke-Marchant, Thomas Kunicki, Fabio M. Pulcinelli, Koneti Rao
• Clopidogrel Resistance
• Chair: Alan Michelson
• Members: Marco Cattaneo, Christian Gachet, Chiara Cerletti, Paul Gu rbel, Diane Nugent, Paquita Nurden, Koneti Rao

Registries of the SSC Platelet Physiology Subcommittee:

• Bernard-Soulier Syndrome (Dermot Kenny)
• Glanzmann Thrombasthenia (Debbie French)
• Non-immune Thrombocytopenia (Amy Geddis/Jim Bussel)

Alan D. Michelson, M.D.
Chair, Platelet Physiology Subcommittee, SSC/ISTH