Platelet Physiology
June 30, 2006
Oslo Kongressenter, Norway
Chairman: A. Michelson, USA
Co-chairs: J. Bennett, USA; M. Cattaneo, Italy; C. Cerletti, Italy; C. Hayward, Canada; D. Kenny, Ireland;
J. Lopez, USA; D. Nugent, USA; P. Nurden, France; S. Watson, UK
The meeting focused on the standardization of the measurement of platelet function in patients. The topics and speakers were:
- turbidometric platelet aggregometry (Lisa Jennings, Memphis , U.S.A. )
- whole blood platelet aggregometry (Stan Heptinstall, Nottingham , U.K. )
- VerifyNow (Rob Hillman, San Diego , U.S.A. )
- platelet function analyzer (PFA)-100 (Catherine Hayward, Hamilton , Canada )
- Impact cone and plate(let) analyzer (David Varon, Jerusalem, Israel)
- flow cytometry (Alan Michelson, Worcester , U.S.A. )
- thromboxane metabolites (Paola Patrignani, Chieti , Italy )
- other methods (Paul Harrison, Oxford , U.K. )
Official publications of the SSC Platelet Physiology Subcommittee in the past year were:
- Michelson AD, Cattaneo M, Eikelboom JW, Gurbel P, Kottke-Marchant K, Kunicki TJ, Pulcinelli FM, Cerletti C, Rao AK, on behalf of the Platelet Physiology Subcommittee of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis. Aspirin resistance: position paper of the Working Group on Aspirin Resistance . Journal of Thrombosis and Haemostasis 2005;3:1309-1311
- Watson SP, Bahou WF, Fitzgerald D, Ouwehand W, Rao AK, Leavitt AD. Mapping the platelet proteome: a report of the ISTH Platelet Physiology Subcommittee. Journal of Thrombosis and Haemostasis 2005;3:2098-2101
- Hayward CPM, Harrison P, Cattaneo, M, Ortel TL, Rao AK. Platelet function analyzer (PFA)-100 closure time in the evaluation of platelet disorders and platelet function. Journal of Thrombosis and Haemostasis 2006;4:312-319
Registries of the SSC Platelet Physiology Subcommittee are:
- Bernard-Soulier Syndrome (Dermot Kenny)
- Glanzmann Thrombasthenia (Debbie French)
- Non-immune Thrombocytopenia (Amy Geddis/Jim Bussel)
It was resolved to form a Working Group on Platelet Aggregation for the purpose of attempting to gain consensus on how to measure platelet aggregation in the clinical laboratory.
Alan D. Michelson, M.D.
Chair, Platelet Physiology Subcommittee, SSC/ISTH