SCIENTIFIC SUBCOMMITTEE SESSION
6 July 2007 Palexpo, Geneva, Switzerland

Registry of Exogenous Hemostatic Factors

Chair: N. Marsh (Australia)
Co-Chairs: K. Clemetson (Switzerland), M.R. Kini (Singapore), F. Markland Jr (USA) M. McLane (USA), T. Morita (Japan)

Nine members of the Registry including Co-Chairs (Kini, Markland, Clemetson, McLane and Morita) were in attendance plus some 25 guests. Chair Marsh were absent with apologies.

Welcome: R. Manjunatha Kini, Co-Chair (Chaired the meeting)

  1. Meeting was brought to order by the Chairman Dr. Manjunatha Kini.
  2. The minutes of the last meeting were read and there were no questions.
  3. Classification and nomenclature of disintegrins (M. A. McLane) A report on the classification and nomenclature of disintegrins from snake venoms was prepared by with inputs from Dr. Markland and was presented to the committee by Dr. McLane. This new nomenclature system was sent as an official communication of the Registry to SSC. It was published as a short notice in the the Journal of Thrombosis and Haemostasis. Dr. McLane updated the list of disintegrins. The subcommittee agreed unanimously with the new nomenclature and classification. As disintegrins are part of larger precursors containing metalloprotease domains, there was a question how these have to classified. Dr. Kini informed the subcommittee that the classification of metalloproteases will be looked into in the near future by Drs. Ana Moura De Silva and Jay Fox.
  4. Classification and nomenclature of C-type lectin related proteins (K. Clemetson)
    A report on the classification and nomenclature of C-type lectin related proteins from snake venoms was prepared by Dr. Clemetson and Dr. Morita was presented. It is a difficult task as the new proteins are being identified through proteomics and transcriptomics. The new classification and nomenclature was agreed upon by the sunbcommittee. Some minor suggestions were made to fine tune and improve the nomenclature and classification system. Dr. Clemetson agreed to complete the manuscript to describe the details of the new classification and nomeclature soon. This report will be circulated among the members of subcommittee and after approval will be sent to SSC for final approval and publication.
  5. Two new studies on procoagulant proteins from Lonomia obliqua was presented by Dr. Ana Marisa Chudzinski-Tavassi (Brazil) and on new three-finger toxins with anticoagulant activities was presented by Dr. Kini. This was part of our strategy to update some of the new developments in the field.
  6. Organization of the International Conference – We are planning to organize the Fourth International Conference on the Exogenous Factors Affecting Thrombosis and Hemostasis as a satellite meeting to the XXII World Congress to be held in Boston, USA. Dr. McLane, Chairman of the Organizing Committee presented the details of the organization. This conference for three days is planned to commemorate the 25 th anniversry of the first meeting on Exogenous factors in San Diego. The subcommittee agreed with the plan. There were suggestions to include poster sessions and some oral presentations to encourage the participation of graduate students, postdoctoral fellows and young scientists. The subcommittee also unanimously agreed to publish the proceedings in the form of a book (about 500 pages).
  7. Other activities: Dr. Kini asked the subcommittee members for suggestions/ concerns in any other areas of exogenous factors. We agreed to look into metalloproteases and their classification.
  8. The next meeting of the Registry will be held in Vienna (2-5 July, 2008).
  9. Any other matters: As there were no other matters, the meeting was adjourned.