J.J. Badimon reviewed the present status of models to study local delivery devices. It is suggested that pig carotid artery is a necessary step before the application to the pig coronary to study local delivery.

L. Drouet presented four models in four different animal species to study thrombosis and surface passivation. It is suggested that a fiber of fibrin/fibrinogen plays a major role in passivation.

K. Mohlke (for D. Ginsburg) presented mouse genetic resources: genome project tools and transgenic mice. The indications and the cautions for the use of these genetically manipulated mice was discussed. References to Internet access to the mouse genome and transgenic animal databanks will be included on the Animal Model Subcommittee home page on the Internet (www.med.unc.edu/isth/).

G. Johnson presented the document of recommendation on "Restenosis: Which Animal Model is the Best?" by L. Badimon, T. Griggs, and himself on behalf of the Subcommittee. The discussion helped to solve some additional questions such as the following:

• Is there a best large animal model?
• What is the optimal sequence of pre-clinical studies?

  

• How close are we to a small animal model of atherosclerosis?

After an extensive discussion, the chairman proposed that the name of this subcommittee be changed to Animal, Cellular, and Molecular Models of Thrombosis and Haemostasis. This was approved.

The next meeting will be held in Ljubljana, Slovenia, with future subjects:

1. Gene transfer and regulation of gene expression in animal models
2. Review of models of venous thrombosis and pulmonary embolism which could give rise to a document of recommendation for models of venous thrombosis and pulmonary embolism.

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