The Subcommittee meeting was chaired by G. Johnson. Approximately 50 persons attended the meeting. Active discussion of the presentations and resolution occurred.
PROGRAM
The meeting was devoted to presentations on the following three topics:
Dr. Jordi Felez described methods to study expression of plasminogen receptor binding sites on endothelial cells.
Dr. Peter Carmeliet, Leuven, Belgium, described the utility of gene knockout mice in the evaluation of the role of fibrinolytic parameters in the development of atherosclerotic vessels and myocardial response to injury.
Dr. Jose Paramo, Navarra, Spain, described studies of restenosis in atherosclerotic pig arteries and his observations of increased PAI-1 expression.
Dr. Paul Holvoet, Leuven, Belgium, described the important differences between the atherosclerotic lesions seen in rabbits, pigs, and humans, and he presented data on the increased expression of MDA modified LDL in acute coronary syndromes.
Dr. Marcel Levi, Amsterdam, Netherlands, reported on an extensive review of the status of animal models of venous thrombosis. He emphasized the limitations of these models in predicting drug doses and efficacy in human venous thrombosis.
Dr. Gerhard Johnson, Minneapolis, USA, presented a position paper on the use of animal models in the study of arterial restenosis.
FUTURE PLANS