Susan H. Hall, PhD
In our investigations, genomic and proteomic strategies
are used to identify and analyze the activities of novel epididymal proteins. Our
overall goal is to develop a better understanding of the functions of the
epididymis and its role in the molecular processes that result in sperm
maturation. We have identified epididymis-specific expressed sequences in
the database of
Human Genome Sciences, Inc
(Rockville, MD) and in an epididymis-specific Macaca mulatta cDNA
library. The efficacy of epididymal proteins as male contraceptive targets
is being tested. We are also interested in androgen receptor action in the epididymis and in the networks
of genes regulated by androgens in different regions of the epididymis. The
mechanisms underlying region-specific androgen-regulated gene expression are
not well understood, but novel insights may emerge from microarray analyses.
The following data files provide supplementary
Data associated with the manuscript: Radhakrishnan Y, Hamil KG, Yenugu S, Young SL, French FS, Hall SH. 2005. Identification, characterization and evolution of a primate beta-defensin gene cluster. Genes Immun 6:
The following data files are in Mega format. They can be opened and further analyzed in MEGA, (Molecular Evolutionary Genetics Analysis) software available at: http://www.megasoftware.net/.
Datafile1.meg The aligned
macaque and human beta defensin cDNA sequences
If you are using a PC please use the "save file" or "save link target as" command by right clicking the link.
If you are using Netscape on a Mac hold down your mouse button over the link and select the "save link target as" command. If you are using Internet Explorer hold down your mouse button over the link and select "download link to disk". Please email Susan Hall if you have questions or difficulty downloading files.
The Laboratories for Reproductive Biology
* Property of PubMed