Original Research Articles



Hodowanec AC, Lee RD, Brady KE, Gao W, Kincaid S, Plants J, Bahk M, Mackman N, Landay AL, Huhn GD. A matched cross-sectional study of the association between circulating tissue factor activity, immune activation and advanced liver fibrosis in hepatitis C infection. BMC Infect Dis. 2015. PMID: 25884329.

Sparkenbaugh EM, Chantrathammachart P, Wang S, Jonas W, Kirchhofer D, Gailani D, Gruber A, Kasthuri R, Key NS, Mackman N, Pawlinski R.Excess of heme induces tissue factor-dependent activation of coagulation in mice. Haematologica. 2015. PMID: 25596265.

Getz TM, Piatt R, Petrich BG, Monroe D, Mackman N, Bergmeier W. Novel mouse hemostasis model for real-time determination of bleeding time and hemostatic plug composition. J Thromb Haemost. 2015. PMID: 25442192.

Stavrou EX, Fang C, Merkulova A, Alhalabi O, Grobe N, Antoniak S, Mackman N, Schmaier AH.Reduced thrombosis in Klkb1-/- mice is mediated by increased Mas receptor, prostacyclin, Sirt1, and KLF4 and decreased tissue factor. Blood. 2015. PMID: 25339356.

Kothari H, Keshava S, Vatsyayan R, Mackman N, Rao LV, Pendurthi UR. Role of tissue factor in Mycobacterium tuberculosis-induced inflammation and disease pathogenesis. PLoS One. 2014. PMID: 25462128.

Magnus N, Meehan B, Garnier D, Hashemi M, Montermini L, Lee TH, Milsom C, Pawlinski R, Ohlfest J, Anderson M, Mackman N, Rak J. The contribution of tumor and host tissue factor expression to oncogene-driven gliomagenesis. Biochem Biophys Res Commun. 2014. PMID: 25450387.

Bode MF, Mackman NProtective and pathological roles of tissue factor in the heart. Hamostaseologie. 2015. PMID: 25434707.

Tatsumi K, Antoniak S, Monroe DM 3rd, Khorana AA, Mackman N; Subcommittee on Hemostasis and Malignancy. Evaluation of a new commercial assay to measure microparticle tissue factor activity in plasma: communication from the SSC of the ISTH. J Thromb Haemost. 2014. PMID: 25186801.

Vatsyayan R, Kothari H, Mackman N, Pendurthi UR, Rao LV. Inactivation of Factor VIIa by Antithrombin In Vitro, Ex Vivo, and In Vivo: Role of Tissue Factor and Endothelial Cell Protein C Receptor. PLoS One. 2014. PMID: 25102166.

Lopez M, Kopec AK, Joshi N, Geddings JE, Cline H, Towery KL, Rockwell CE, Mackman N, Luyendyk JP. Fas-Induced Apoptosis Increases Hepatocyte Tissue Factor Procoagulant Activity In Vitro and In Vivo. Toxicol Sci. 2014. PMID: 25016558. 

Aleman MM, Byrnes JR, Wang JG, Tran R, Lam WA, Di Paola J, Mackman N, Degen JL, Flick MJ, Wolberg AS. Factor XIII activity mediates red blood cell retention in venous thrombi. J Clin Invest. 2014. PMID: 24983320.

Magnus N, Garnier D, Meehan B, McGraw S, Lee TH, Caron M, Bourque G, Milsom C, Jabado N, Trasler J, Pawlinski R, Mackman N, Rak J. Tissue factor expression provokes escape from tumor dormancy and leads to genomic alterations. Proc Natl Acad Sci USA. 2014. PMID: 24520174.

Sparkenbaugh EM, Chantrathammachart P, Mickelson J, van Ryn J, Hebbel RP, Monroe DM, Mackman N, Key NS, Pawlinski R. Differential contribution of FXa and thrombin to vascular inflammation in a mouse model of sickle cell disease. Blood. 2014. PMID: 24449213. 

Bharthuar A, Khorana AA, Hutson A, Wang JG, Key NS, Mackman N, Iyer RV.  Circulating microparticle tissue factor, thromboembolism and survival in pancreaticobiliary cancers.  Thromb Res.  In press.  2013.  PMID:  23856554.

Weithauser A, Bobbert P, Antoniak S, Böhm A, Rauch BH, Klingel K, Savvatis K, Kroemer HK, Tschope C, Stroux A, Zeichhardt H, Poller W, Mackman N, Schultheiss HP, Rauch U.  Protease-activated receptor 2 regulates the innate immune response to viral infection in a CVB3-induced myocarditis.  J Am Coll Cardiol.  2013.  

Luo D, Lin JS, Parent MA, Mullarky-Kanevsky I, Szaba FM, Kummer LW, Duso DK, Tighe M, Hill J, Gruber A, Mackman N, Gailani D, Smiley ST.  Fibrin facilitates both innate and T cell-mediated defense against Yersinia pestis.  J Immunol. 2013. 

Sullivan BP, Kopec AK, Joshi N, Cline H, Brown JA, Bishop SC, Kassel KM, Rockwell C, Mackman N, Luyendyk JP.  Hepatocyte tissue factor activates the coagulation cascade in miceBlood. 121(10):1868-74, 2013.

Antoniak S, Owens AP 3rd, Baunacke M, Williams JC, Lee RD, Weithäuser A, Sheridan PA, Malz R, Luyendyk JP, Esserman DA, Trejo J, Kirchhofer D, Blaxall BC, Pawlinski R, Beck MA, Rauch U, Mackman NPAR-1 contributes to the innate immune response during viral infection.  J Clin Invest. 123(3):1310-22, 2013. 

Thaler J, Ay C, Mackman N, Metz-Schimmerl S, Stift J, Kaider A, Müllauer L, Gnant M, Scheithauer W, Pabinger I.  Microparticle-associated tissue factor activity in patients with pancreatic cancer: correlation with clinicopathological features.  Eur J Clin Invest. 43(3):277-85, 2013.  

Boulaftali Y, Hess PR, Getz TM, Cholka A, Stolla M, Mackman N, Owens AP 3rd, Ware J, Kahn ML, Bergmeier W. Platelet ITAM signaling is critical for vascular integrity in inflammationJ Clin Invest. 123(2):908-16, 2013.  

Bastarache JA, Sebag SC, Clune JK, Grove BS, Lawson WE, Janz DR, Roberts LJ 2nd, Dworski R, Mackman N, Ware LB.  Low levels of tissue factor lead to alveolar haemorrhage, potentiating murine acute lung injury and oxidative stressThorax. 67(12):1032-9, 2012. 

Darbousset R, Thomas GM, Mezouar S, Frére C, Bonier R, Mackman N, Renné T, Dignat-George F, Dubois C, Panicot-Dubois L. Tissue factor positive neutrophils bind to injured endothelial wall and initiate thrombus formation. Blood.  120: 2133-2143, 2012. 

Marchi R, Walton BL, McGary CS, Lin FC, Ma AD, Pawlinski R, Mackman N, Campbell RA, Di Paola J, Wolberg AS. Dysregulated coagulation associated with hypofibrinogenaemia and plasma hypercoagulability: Implications for identifying coagulopathic mechanisms in humans. Thromb Haemost, 108: 516-526, 2012.  

Lee R, Williams JC, Mackman N. P2X7 Regulation of Macrophage Tissue Factor Activity and Microparticle Generation. J Thromb Haemost, 10: 1965-1967, 2012.  

Chantrathammachart P, Mackman N, Sparkenbaugh E, Wang JG, Parise LV, Kirchhofer D, Key NS, Pawlinski R. Tissue factor promotes activation of coagulation and inflammation in a mouse model of sickle cell disease. Blood. 120:636-46, 2012. 

Jaffré F, Friedman AE, Hu Z, Mackman N, Blaxall BC. Beta-adrenergic receptor stimulation transactivates protease-activated receptor 1 via matrix metalloproteinase 13 in cardiac cells. Circulation. 125:2993-3003, 2012. 

Wang JG, Geddings JE, Aleman MM, Cardenas JC, Chantrathammachart P, Williams JC, Kirchhofer D, Bogdanov VY, Bach RR, Rak J, Church FC, Wolberg AS, Pawlinski R, Key NS, Yeh JJ, Mackman N. Tumor-derived tissue factor activates coagulation and enhances thrombosis in a mouse xenograft model of human pancreatic cancer. Blood. 119:5543-52, 2012. 

Weitz, I.C., Razavi, P., Ghods, M., Rochanda, L., Zwicker, J., Furie, B., Manly, D.A., Mackman, N., Green, R., Liebman, H.A. Eculizmab therapy results in rapid and sustained decreases in markers of thrombin generation and inflammation in patients with paroxysmal nocturnal hemoglobinuria.  Thromb. Res. 130(3):361-82012, 2012.  

Van Doormaal, F.F., Kleinjan, A., Berckmans, R.J., Mackman, N., Manly, D.A., Kamphuisen, P.W., Richel, D.K., Buller, H.R., Sturk, A., Nieuwland, R. Coagulation activation and microparticle-associated coagulant activity in cancer patients.  Thromb. Haemost. 108:160-165, 2012. 

Thaler, J., Ay, C., Mackman, N., Bertina, R.M., Kaider, A., Marosi, C., Key, N.S., Barcel, D.A., Scheithauer, W., Kornek, G., Zielinski, C., Pabinger, I. Microparticle-associated tissue factor activity, venous thromboembolism and mortality in pancreatic, gastric, colorectal and brain cancer patients. J. Thromb. Haemost. 10:1363-1370, 2012. 

von Brühl, M.L., Stark, K., Steinhart, A., Chandraratne, S., Konrad, I., Lorenz, M., Khandoga, A., Tirniceriu, A., Coletti, R., Köllnberger, M., Byrne, R.A., Laitinen, I., Walch, A., Brill, A., Pfeiler, S., Manukyan, D., Braun, S., Lange, P., Riegger, J., Ware, J., Eckart, A., Haidari, S., Rudelius, M., Schulz, C., Echtler, K., Brinkmann, V., Schwaiger, M., Preissner, K.T., Wagner, D.D., Mackman, N., Engelmann, B., Massberg, S. Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo. J. Exp. Med., 209:818-835, 2012. 

Kasthuri, R.S., Glover, S.L., Jonas, W., McEachron, T., Pawlinski, R., Arepally, G.M., Key, N.S., Mackman, N. PF4/heparin-antibody complex induces monocyte tissue factor expression and release of tissue factor positive microparticles by activation of FcyR1. Blood, 119:5285-5293, 2012. 

Boltzen, U., Eisenreich, A., Antoniak, S., Weithaeuser, A., Fechner, H., Poller, W., Schultheiss, H.P., Mackman, N., Rauch, U. Alternatively spliced tissue factor and full-length tissue factor protect cardiomyocytes against TNF-α-induced apoptosis. J. Mol. Cell Cardiol., 52:1056-1065, 2012. 

Owens, A.P. 3rd, Passam, F.H., Antoniak, S., Marshall, S.M., McDaniel, A.L., Rudel, L., Williams, J.C., Hubbard, B.K., Dutton, J.A., Wang, J., Tobias, P.S., Curtiss, L.K., Daugherty, A., Kirchhofer, D., Luyendyk, J.P., Moriarty, P.M., Nagarajan, S., Furie, B.C., Furie, B., Johns, D.G., Temel, R.E., Mackman, N. Monocyte tissue factor-dependent activation of coagulation in hypercholesterolemic mice and monkeys is inhibited by simvastatin. J. Clin. Invest. 122:558-568, 2012. 

Boles JC, Williams JC, Hollingsworth RM, Wang JG, Glover SL, Owens AP 3rd, Barcel DA, Kasthuri RS, Key NS, Mackman N. Anthracycline treatment of the human monocytic leukemia cell line THP-1 increases phosphatidelserine exposure and tissue factor activity. Thromb Res. 129:197-203, 2012. 

Hampton, A.L., Diaz, J.A., Hawley, A.E., Wrobleski, S.K., Wang, J.G., Lee, R.D., Kirchhofer, D., Sigler, R.E., Wakefield, T.W., Mackman, N., Myers, D.D. Jr. Myeloid cell tussue factor does not contribute to venous thrombogenesis in an electrolytic injury modelThromb. Res., 2011. In press.

Williams, J.C., Lee, R.D., Doerschuk, C.M., Mackman, N. Effect of PAR-2 deficiency in mice on KC expression after intratracheal LPS administration. J. Signal Transduct. 2011:415195, 2011. 

Cronan, M.R., Nakamura, K., Johnson, N.L., Granger, D.A., Cuevas, B.D., Wang, J.G., Mackman, N., Scott, J.E., Dohlman, H.G., Johnson, G.L. Defining MAP3 kinases required for MDA-MB-231 cell tumor growth and metastasis. Oncogene, 2011. 

Kassel, K.M., Owens, A.P. 3rd, Rockwell, C.E., Sullivan, B.P., Wang, R., Tawfik, O., Li, G., Guo, G.L., Mackman, N., Luyendyk, J.P. Protease-activated receptor 1 and hematopoietic cell tissue factor are required for hepatic steatosis in mice fed a Western diet. Am. J. Pathol. 179:2278-89, 2011. 

McEachron TA, Church FC, Mackman N. Regulation of thrombin-induced plasminogen activator inhibitor-1 in 4T1 murine breast cancer cellsBlood Coagul Fibrinolysis 576-82, 2011.

Liu, Y., Jiang, P., Capkova, K., Xue, D., Ye, L., Sinha, S.C., Mackman, N., Janda, K.D., Liu, C. Tissue factor-activated coagulation cascade in the tumor microenvironment is critical for tumor progression and an effective target for therapy. Cancer Res. 714:6492-6502, 2011.

Owens AP 3rdLu YWhinna HCGachet CFay WPMackman N. Towards a standardization of the murine ferric chloride-induced carotid arterial thrombosis model. J Thromb Haemost 9:1862-3, 2011. 

Lee RD, Barcel DA, Williams JC, Wang JG, Boles JC, Manly DA, Key NS, Mackman N. Pre-analytical and analytical variables affecting the measurement of plasma-derived microparticle tissue factor activityThromb Res 129:80-5, 2012.

Wang JG, Williams JC, Davis BK, Jacobson K, Doerschuk CM, Ting JP, Mackman N. Monocytic microparticles activate endothelial cells in an IL-1β-dependent mannerBlood 118:2366-74, 2011.

Owens AP 3rd, Mackman N. Microparticles in hemostasis and thrombosisCirc Res 108:1284-97, 2011.

Antoniak SPawlinski RMackman N. Protease-activated receptors and myocardial infection. IUBMB Life 63:383-9, 2011. 

Williams JCMackman N. MPs or ICs? Blood 117: 1101-2, 2011. 

Key, N.S., Mackman N.Tissue factor and its measurement in whole blood, plasma, and microparticles.  Semin Thromb Hemost 36:865-75, 2010.

Kasthuri R.S., Glover S.L., Boles J., Mackman N. Tissue factor and tissue factor pathway inhibitor as key regulators of global hemostasis: measurement of their levels in coagulation assays. Semin Thromb Hemost 36:764-71, 2010.

McEachron, T.A., Pawlinski, R., Richards, K.L., Church, F.C., Mackman, N. Protease-activated receptors mediate crosstalk between coagulation and fibrinolysis. Blood 116:5037-44, 2010.

Manly, D.A., Boles, J., Mackman, N. Role of Tissue Factor in Venous Thrombosis. Annu Rev Physiol. 2010.

Pawlinski, R., Wang, J-G., Owens, A.P., Williams, J., Antoniak, S., Tencati, M., Luther, T., Rowley, J.W., Low, E.N., Weyrich, A.S., Mackman, N. Hematopoietic and non-hematopoietic cell tissue factor activates the coagulation cascade in endotoxemic mice. Blood 116: 806-14, 2010.

Manly, D. A., Wang, J-G., Glover, S.L., Kasthuri, R., Liebman, H.A., Key, N.S., Mackman, N. Increased microparticle tissue factor activity in cancer patients with venous thromboembolism. Thromb Res in press.

Seshan, S.V., Franzke, C.W., Redecha, P., Monestier, M., Mackman, N., Girardi, G. Role of tissue factor in a mouse model of thrombotic microangiopathy induced by antiphospholipid antibodies. Blood 114: 1675-1683.

Raetzsch, C.F., Brooks, N. L., Alderman, J.M., Moore, K.S., Hosick, P.A., Klebanov, S., Akira, S., Bear, J.E., Baldwin, A.S., Swenberg, J.A., Mackman, N., Combs, T.P. LPS inhibition of glucose production is mediated by the TRL4, MyD88, NF-κB pathway. Hepatology 50:592-600,2009.

Baker, A.K., Wang, R., Mackman, N., Luyendyk, J.P. PI3K-Akt pathway-dependent inhibition of LPS-induced tissue factor and cytokine expression in macrophages: role of mTOR-dependent IL-10 expression. Mol Immunol 46:2249-2255, 2009.

Wang, J-G., Manly, D., Kirchhofer, D., Pawlinski, R. Mackman, N. Levels of tissue factor activity correlate with coagulation activation in endotoxemic mice. J.Thromb. Haemost. 7:1092-1098, 2009.

Ollivier, V., Wang, J., Manly, D., Machlus, K., Wolberg, A. S., Jandrot-Perrus, M., and Mackman, N. Detection of endogenous tissue factor levels in plasma using the calibrated automated thrombogram assay. Thromb. Res. In press.

Rong, Y., Belozerov, V.E., Tucker-Burden, C., Chen, G., Durden, D.L., Olson, J.J., Van Meir, E.G., Mackman, N., Brat, D.J. Epidermal growth factor receptor and PTEN modulate tissue factor expression in glioblastoma through JunD/activator protein-1 transcriptional activity. Cancer Res. 69:2540-2549, 2009.

Luyendyk, J.P., Cantor G. H., Kirchhofer, D., Mackman, N. Copple, B.L., Wang, R. Tissue factor-dependent coagulation contributes to alpha-naphthylisothiocyanate-induced cholestatic liver injury in mice. Am. J. Physiol. Gastrointest. Liver Physiol. 296:G840-G849.

Wang, L., Miller, C., Swarthout, R.F., Rao, M., Mackman, N., Taubman, M.B. Vascular smooth muscle-derived tissue factor is critical for arterial thrombosis after ferric chloride-induced injury. Blood 113: 705-713, 2009.

Li, Y-D., Ye, B-Q., Zheng, S-X., Wang, J-T., Wang-J-G., Chen, M., Liu, J-G., Pei, X-H., Wang, L-J., Lin, Z-X., Gupta, K., Mackman, N., Slungaard, A., Key, N.S., Geng, J-G. NF-κB transcription factor p50 critically regulates tissue factor in deep vein thrombosis. J. Biol. Chem. 284:447-483, 2009.

Khorona, A.A., Francis, C.W., Menzies, K.E., Wang, J-G., Hyrien, O., Hathcock, J., Mackman, N., Taubman, M.B. Plasma tissue factor may be predictive of venous thromboembolism in pancreatic cancer. J. Thromb. Haemost. 6:1983-1985, 2008.

Milsom, C. C., Yu, J.L., Mackman, N., Micallef, J., Anderson, G. M., Guha, A., Rak, J. W. Tissue factor regulation by epidermal growth factor receptor and epithelial-to-mesechymal transitions:effect on tumor progression and angiogenesis. Cancer Res. 68:10068-10076. 2008.

Yu, J., May, L., Milsom, C., Anderson, G.M., Weitz. J.I, Luyendyk, J. P., Broze, G., Mackman, N., Rak, J. Contribution of host-derived tissue factor to tumor neovascularization. Arterioscler. Thromb. Vasc. Biol. 28:1975-1981, 2008.

Redecha, P., Franzke, C-W., Ruf, W., Mackman, N., Girardi, G. Activation of neutrophils by the tissue factor- factor VIIa-PAR-2 axis mediates fetal death in antiphospholipid syndrome. J. Clin. Invest. 118:3453-3461, 2008.

Kidd, L., Schabbauer, G. A., Luyendyk, J. P., Holscher, T.D., Tilley, R.E., Tenacati, M., Mackman, N. Insulin activation of the PI3K/Akt pathway reduces LPS-induced inflammation in mice. J. Pharmacol. Exp. The.r 326:348-353, 2008.

Hoffmann, E., Ashouri, J., Wolter, S., Doerrie, A., Dittrich-Breiholtz, O., Scneider, H., Wagner, E.F., Troppmair, J., Mackman,N., Kracht, M. Transcriptional regulation of EGR-1 by the IL-1-JNK-MKK7-c-JUN pathway. J. Biol. Chem. 283:12120-12128, 2008.

Schabbauer, G., Luyendyk, J., Crozat, K., Jiang, Z., Mackman, N., Bahram, S., Georgel, P. TLR4/CD14-mediated PI3K activation is an essential component of interferon-dependent VSV resistance in macrophages. Mol. Immunol. 45:2790-2796, 2008.

Luyendky, J.P., Schabbauer, G.A., Tencati, M., Holscher, T., Pawlinski, R., Mackman, N. Genetic analysis of the role of the PI3K-Akt pathway in LPS-induced cytokine and tissue factor gene expression in monocytes/macrophages. J.Immunol. 180:4218-4226, 2008.

Bhattacharjee, G., Ahamed, J., Pawlinski, R., Liu, C., Mackman, N., Ruf, W., Edgington, T.S. Factor Xa binding to annexin 2 mediates signal transduction via protease activated receptor-1. Circ. Res. 102:457-464, 2008.

Reinhardt, C., von Bruhl, M-L., Masnukyan, D., Grahl, L.,, Lorebz, M., Altmann, B., Dlugai, S., Hess, S., Konrad, I., Orschiedt, L., Mackman, N., Ruddock, L., Massberg, S., Engelmann, S. Protein disulfide isomerase can signal vessel injury for initiation of fibrin generation. J. Clin. Invest. 118:1110-1122, 2008.

Tilley, R.E., Holscher, T., Belani, R., Nieva, J., Mackman, N. Tissue factor activity is increased in a combined platelet and microparticle sample from cancer patients. Thromb. Res., 122: 604-609, 2008.

Pawlinski, R., Tencati, M., Hampton, C.R., Shishido, T., Bullard, T.A., Casey, L.M., Andrade-Gordon, P., Spring, D., Kotzsch, M., Luther, T., Abe, J., Pohlman, T., Verrier, E.D., Blaxall, B., Mackman, N. Role of PAR1 in cardiac remodeling and hypertrophy. Circulation 116:2298-2306, 2007.

Kerschen, E.J., Fernandez, J.A., Cooley, B.C., Yang, X.V., Sood, R., Mosnier, L.O., Castellino, F.J., Mackman, N., Griffin, J.H., Weiler, H. Endotoxemia and sepsis mortality by non-anticoagulant activated protein C. J. Exp. Med. 204:2439-2448, 2007.

Ghosh, M., Wang, H., Ai, Y., Romeo, E., Luyendyk, J.P., Peters, J.M., Mackman, N., Dey, S.K., Hla, T. COX-2 suppresses tissue factor expression via endocannabinoid-directed PPARδ activation. J. Exp. Med. 204:2053-2061, 2007.

Pawlinski, R., Tencati, M., Holscher, T., Pedersen, B., Voet, T., Tilley, R.E., Marynen, P., Mackman, N. Role of cardiac myocyte tissue factor in heart hemostasis. J. Thromb. Haemost. 5:1693-1700, 2007.

Redecha, R., Tilley, R., Tencati, M., Salmon, J., Kirchhofer, D., Mackman, N., Girardi, G. Tissue factor: a link between C5a and neutrophil activation in antiphospholipid antibody-induced fetal injury. Blood 110:2433-2431, 2007.

Luyendyk, J.P., Piper, J.D., Tencati, M., Reddy, K.V., Holscher, T., Zhang, R., Luchoomun, J., Chen, X., Min, W., Kunsch, C., Mackman, N. A novel class of antioxidants inhibits LPS induction of tissue factor by selective inhibition of the activation of ASK1 and MAP kinases. Arterioscler. Thromb. Vasc. Biol. 27: 1857-1563, 2007.

Ganey, P., Luyendyk, J. Newport, S., Eagle, T. Maddow, J. Mackman, N., Roth, R. Role of coagulation system activation in acetaminophen-induced hepatotoxicity in mice. Hepatology 46:1177-1186, 2007.

Shigeoka, A., Hoscher, T.D., King, A.J., Hall, F.W., Kiosses, W.B., Tobias, P.S., Mackman, N., McKay, D.B. TLR2 is constitutively expressed within the kidney and participates in ischemic renal injury through both myD88-dependent and independent pathways. 2007 J. Immunol. 178: 6252-6258, 2007.

Davis, D., Wilson, K., Sam, M., Kennedy, S., Mackman, N., Charlesworth, J., Erlich, J. The development of cardiac fibrosis in low tissue factor mice is gender-dependent and is associated with differential expression of urokinase plasminogen activator. J. Mol. and Cell. Cardiol 42:559-71, 2007.

Sevastos, J., Kennedy, S.E., Davis, D.R., Sam, M., Peake, P.W., Charlesworth, J.A., Mackman, N., Erlich, J.H. Tissue factor deficiency and PAR-1 deficiency are protective against renal ischemia reperfusion injury. Blood, 109:577-583, 2007.

Frank, R.D., Holscher, T., Schabbauer, G. Tencati, M., Pawlinski, R., Weitz, J.I., Mackman, N. The anti-inflammatory activity of a synthetic pentasaccharide is not dependent on its anticoagulant activity. Throm. Haemost, 96:802-806, 2006.

Schwertz, H., Tolley, N.D., Foulks, J.M.,Denis, M.M., Risenmay, B.W., Buerke, M., Tilley, R.E., Rondina M.T., Harris, E.M., Kraiss, L.W., Mackman, N., Zimmerman, G.A.,Weyrich, A.S. Signal-dependent pre-mRNA splicing modulates the pro-coagulant activity of human platelets. J. Exp. Med. 20:2433-2440, 2006.

Mullarky, I.K., Szaba, F.M., Winchel, C.G., Parent, M.A., Kummer, L.W., Mackman, N., Johnson, L.L., Smiley, S.T. In situ hemostasis assays demonstrate that interferon-gamma suppresses infection-stimulated hepatic fibrin deposition by promoting fibrinolysis. J. Thromb. Haemost. 4:1580-1587, 2006.

Rong, Y., HU, F., Huang, R.P., Mackman, N., Horowitz, J.M., Jensen, R.L., Durden, D.L., Van Meir, E.G., Brat, D.J. Egr-1 regulates hypoxia-induced expression of tissue factor in glioblastoma through HIF-1α independent mechanisms. Cancer Res. 66:7067-7074, 2006.

Tilley, R.E., Pedersen, B., Pawlinski, R., Sato, Y., Erlich, J.H., Shen, Y., Day, S., Huang, Y., Eitzman, D. T., Boisvert, W.A., Curtiss, L. K., Fay, W. P., Mackman, N. Atherosclerosis in mice is not affected by a reduction in tissue factor expression. Arterioscler. Thromb .Vasc. Biol. 26:555-562, 2006.

Hayashi, M, Matsushita, T., Mackman, N., Ito, M., Adachi, T., Katsumi, A., Yamamoto, K., Takeshita, K., Kojima, T., Saito, H., Murohara, T., Naoe, T. Fatal thrombosis of antithrombin deficient mice is rescued differently in the heart and liver by intercrossing with low tissue factor mice. J. Thromb. Haemost. 4:177-185, 2006.

Motton, D.D., Mackman, N., Tilley, R.E., Rutledge, J.C. Postprandial elevation of tissue factor antigen in the blood of healthy adults. Thromb. Haemost. 94:504-509, 2005.

Kamimura, M., Viedt, C., Dalpke, A., Rosenfeld, M.E., Mackman, N., Cohen, D.M., Blessing, E., Preusch, M., Weber, C.M., Kreuzer, J., Katus, H.A., Bea, F. Interleukin-10 suppresses tissue factor expression in lipopolysaccharide-stimulated macrophages via inhibition of Egr-1 and a serum response element/MEK-ERK1/2 pathway. Circ. Res.97:305-13, 2005.

Rushworth, S.A., Chen, X-L., Mackman, N., Ogborne, R.M., O’Connell, M.A. LPS-induced heme oxygenase-1 expression in human monocytic cells is mediated via Nrf2 and protein kinase C. J. Immunol. 175:4408-15, 2005.

Bhattacharjee, G., Ahamed, J., Pedersen, B., El-Sheikh, A., Mackman, N., Ruf, W., Liu, C., Edgington, T.S. Regulation of tissue factor-mediated initiation of the coagulation cascade by cell surface Grp78. Arterioscler. Thromb. Vasc. Biol. 25:1737-43, 2005.

Morrow, D.A., Murphy, S.A., McCabe, C.H., Mackman, N., Wong, H.C., Antman, E.M. Potent inhibition of thrombin with a monoclonal antibody against tissue factor (Sunol-cH36): results of the PROXIMATE-TIMI 27 trial. Eur. Heart J. 26:682-8, 2005.

Pedersen, B., Holscher, T., Sato, Y., Pawlinski, R., Mackman, N. A balance between tissue factor and tissue factor pathway inhibitor is required for embryonic development and hemostasis in adult mice. Blood 105:1734-41, 2005.

Frank, R.D., Schabbauer, G., Holscher, T., Sato, Y., Tencati, M., Pawlinski, R., Mackman, N. The synthetic pentasaccharide, fondaparinux, reduces coagulation, inflammation and neutrophil accumulation in kidney ischemia-reperfusion injury. J. Thromb. Haemost. 3:531-40, 2005.

Yu, L.J., May, L., Lhotak, V., Shahrzad, S., Shirasawa, S., Weitz, J.I., Comber, B.L., Mackman, N., Rak, J.W. Oncogenic events regulate tissue factor expression in colorectal cancer cells: implications for tumor progression and angiogenesis. Blood 105:1734-41, 2005.