Lubna Abdullah, PhD

DavisLab1

Lubna Abdullah, PhD

Research Associate in the laboratory of Dr. C. William Davis

Research Focus

Lubna Abdullah is studying the pathways underlying mucin synthesis and secretion in human bronchial epithelial cells.  Of specific interest is the post-secretory maturation of mucins, which may be dysfunctional in cystic fibrosis, the relationships between mucin glycoprotein secretion and synthesis under control versus inflammatory conditions, and the branches of the secretory pathway used for mucin secretion.

Recent Publications

  1. Zhu, Yunxiang, et al. "Baseline Goblet Cell Mucin Secretion in the Airways Exceeds Stimulated Secretion over Extended Time Periods, and Is Sensitive to Shear Stress and Intracellular Mucin Stores." PloS one 10.5 (2015): e0127267.
  2. Henderson, Ashley G., et al. "Cystic fibrosis airway secretions exhibit mucin hyperconcentration and increased osmotic pressure." The Journal of clinical investigation 124.7 (2014): 3047.
  3. Schwab, Ute, et al. "Localization of Burkholderia cepacia complex bacteria in cystic fibrosis lungs and interactions with Pseudomonas aeruginosa in hypoxic mucus." Infection and immunity 82.11 (2014): 4729-4745.
  4. Okada, Seiko F., et al. "Inflammation promotes airway epithelial ATP release via calcium-dependent vesicular pathways." American journal of respiratory cell and molecular biology 49.5 (2013): 814-820.
  5. Okada, Seiko F., et al. "Coupled nucleotide and mucin hypersecretion from goblet-cell metaplastic human airway epithelium." American journal of respiratory cell and molecular biology 45.2 (2011): 253-260.

Contact Information

7110 Marsico Hall
The University of North Carolina at Chapel Hill
Phone: (919) 966-8615
Email: lubna_abdullah@med.unc.edu