Learning How Two Gut Pathogens Worsen Malnutrition In Children

Dr. Luther Bartelt is a faculty physician in the division of infectious diseases, researching two gut pathogens commonly found in malnourished children that impair growth. Dr. Bartelt developed a laboratory mouse model of co-infection during malnutrition, and the results of his work have been published in PLOS Pathogens.

Learning How Two Gut Pathogens Worsen Malnutrition In Children click to enlarge Luther Bartelt, M.D., helped develop a new laboratory mouse model to study malnutrition.

(Excerpts republished from the UNC Institute for Global Health & Infectious Diseases)

Malnourished children often face infection with pathogenic microbes that colonize the intestines. These infections disrupt healthy gut microbial communities and harm metabolism and immune system function, worsening malnutrition and impairing children’s growth and development. However, the precise effects of co-infection with multiple pathogens in malnourished children are poorly understood.

To gain new insights, Luther Bartelt, M.D., instructor in the Division of Infectious Diseases at the University of North Carolina at Chapel Hill and colleagues developed a new laboratory mouse model of co-infection during malnutrition.

The results published in PLOS Pathogens could advance restoration of health gut conditions in malnourished children.

To read the full story, go to UNC Institute for Global Health & Infectious Diseases