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Research Mentor |
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Associate Professor
Genetics
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Carolina Center for Genome Sciences
Lineberger Comprehensive Cancer Center
Center for Gastrointestinal Biology and Disease
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Michelle DeSimone |
Toxicology |
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Clinical Co-Mentor |
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Assistant Professor
Medicine |
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Hematology and Oncology
Lineberger Comprehensive Cancer Center
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Identification of Chemical-Exposure Signatures in Renal Cell Carcinomas |
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Michelle DeSimone seeks to identify molecular biomarkers of trichloroethylene exposure in renal cell carcinomas by examining genetic mutation signatures in tumor tissues from human populations, and thereby develop preventative measures and therapeutic strategies for the treatment of chemical-exposure induced cancers. |
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Research Mentor |
Ilona Jaspers, PhD |
Assistant Professor
Dept of Pediatrics |
Division of Immunology, Rheumatology and Infectious Diseases
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Katherine Horvath
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Toxicology |
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Clinical Co-Mentor |
Terry L. Noah, MD |
Associate Professor
Dept of Pediatrics
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Chief, Division of Pulmonology |
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Exposure to air pollutants, such as diesel exhaust (DE), and viral infections - Do they synergize to increase allergic inflammation in humans? |
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Katherine Horvath is examining the effects of environmental exposures and viral infections on asthma in human subjects. She seeks to determine whether prior exposure to diesel exhaust (DE) exacerbates innate response to viral infection, and to identify potential mechanisms that describe how DE exposure affects virus-induced exacerbation of allergic inflammation.
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Research Mentor |
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Associate Professor
Pharmacology
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Director of Graduate Studies, Pharmacology
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Clinical Co-Mentor |
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Associate Professor
Medicine |
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Carolina Cardiovascular Biology Center
Thurston Arthritis Research Center
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The Application of Novel Antibody Microarrays to Study the Effects
of HSP90 Inhibitors on Lupus |
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Shannon Jones will apply antibody microarray technology (the Medsaic-DotScanTM system) to study the development of the autoimmune disorder, systemic lupus erythematosus (SLE). She seeks to characterize the expression of cluster of differentiation (CD) antigens and investigate the effects of HSP90 inhibitors on CD antigens for the treatment of the disease.
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Research Mentor |
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Research Assistant Professor
Medicine |
Pulmonary and Critical Care Division
Cystic Fibrosis/Pulmonary Research and Treatment Center
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Rachael Liesman |
Microbiology and Immunology |
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Clinical Co-Mentor |
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Kenan Professor
Medicine
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Pulmonary and Critical Care Division
Director,
Cystic Fibrosis/Pulmonary Research and Treatment Center
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Respiratory Virus Infection of the Inflamed Lung: Does Increased
Proteolytic Activity Impact the Severity of Virus Infection? |
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Rachael is investigating the role of respiratory viruses in precipitating acute exacerbations of preexisting chronic lung diseases such as Chronic Obstructive Pulmonary Disease (COPD), Cystic Fibrosis (CF) and asthma. Using a model of human ciliated airway epithelium (HAE), she intends to determine the requirement of extracellular proteases for virus infection and test whether increasted proteolytic activity supplied by addition of CF or COPD patient samples to HAE will potentiate the infectivity and/or consequences of infection by specific viruses.
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Research Mentor |
Monte S. Willis, MD, PhD
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Assistant Professor
Pathology and Laboratory Medicine |
Carolina Cardiovascular Biology Center
Asst. Director, Clinical Core (Chemistry) Laboratory
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Jessica Rodriguez |
Pathology |
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Clinical Co-Mentor |
Craig Selzman, MD |
Assistant Professor
Surgery
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Division of Cardothoracic Surgery
Carolina Cardiovascular Biology Center
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The Role of Ring Finger 1 (MuRF1) in Protein Quality Control in the Heart
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Jessica is studying the process of protein quality control in the heart--how cellular proteins are monitored to determine if they are functional, damaged, mis-folded or fit for further use. She is investigating the involvement of MuRF1, a key regulator of skeletal muscle atrophy, in this process.
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Research Mentor |
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Associate Professor
Medicine, Immunology |
Member,
Bone Marrow Transplantation Program,
Lineberger Comprehensive
Cancer Center
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Joseph Burgents |
Microbiology and Immunology |
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Role of Treg Migration in T Cell Medicated Melanoma Clearance
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The long term goal of Joseph Burgents's study is to improve the treatment of cancer with vaccines. Using mouse models in the laboratory he studies the regulation of T cells during clearance of melanomas. |
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Research Mentor |
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Associate Professor
Psychiatry, Psychology |
Director
Neuroimaging Research in Psychiatry (UNC-CH)
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Kimberly Hills Carpenter |
Neurobiology |
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Clinical Co-Mentor |
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Professor
Psychiatry |
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Director
Neurodevelopmental
Disorders Research Center
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Functional Neuroimaging to Investigate the Role of
the Amygdala
in Autistic Social Processing
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Autism is a chronic developmental disorder characterized by delay or absence of language acquisition, aberrant social interactions, repetitive behaviors and restricted interest. It is the second most prevalent developmental disorder after mental retardation, yet its physical basis is unknown. Kimberly is using human functional neuroimaging to investigate a role of a part of the brain called the amygdala in autistic social processing. Her mentors are long standing collaborators in characterizing the functional basis of neurodevelopmental disorders.
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Research Mentor |
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Professor
Physiology, Pediatrics,
Nutrition |
Member, Center for Gastrointestinal Biology and Disease
Member, Lineberger Cancer Center
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Kathryn Hamilton |
Physiology |
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Clinical Co-Mentor |
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Sessions Distinguished Professor
of Medicine
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Chief of GI
Director
NIH P30 GI Center
Member, NIH National DD Commission
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Role of Suppressor of Cytokine Signaling 3 (SOCS 3)
in Inflammation-Associated
and Sporadic Colorectal Cancer
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Kate Hamilton will determine the relevance of suppressor of cytokine signaling 3 (SOC3) as a possible tumor suppressor in colon cancer. Her laboratory studies use genetically altered mice to define the role of SOC3 in inflammation–associated proliferation. She will translate these basic observations to clinical relevance by asking if low levels of SOC3 expression or epigenetic silencing of SOC3 correlates with increased risk of precancerous lesions in the colons of patients being screened by routine colonoscopy, or in patients with IBD-associated or sporadic dysplasia and neoplasia. Her thesis mentor, Dr. Lund, is a world leader in research on intestinal adaptation. Her clinical co-mentor, Dr. Robert Sandler is a world leader in the epidemiology of colon cancer risk factors and a member of the NIH Digestive Diseases Commission.
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Research Mentor |
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Professor
Physiology
Biomedical Engineering
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Program in Molecular Biology and Biotechnology
Center for Gastrointestinal Biology and Disease
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Rachael Turner |
Biomedical Engineering |
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Clinical Co-Mentor |
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Associate Professor
Surgery
Division of Abdominal Transplant Surgery |
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Director,
Liver Transplant Program
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Engineering of Human Liver Tissue for Bioartifical Livers and for Grafts |
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Over 30,000 patients die annually in the US from liver failure. Of those placed on the transplantation waiting list several thousand die each year because there are insufficient donor livers available. Rachael's research is aimed at developing bioartifical livers to support patients in liver failure. She will attempt to optimize growth conditions for human angioblasts and hepatic stem cells and engineer devices into which they can be seeded. Her thesis mentor Lola Reid works within an extensive international collaborative network of clinical and basic investigators. Her clinician co-mentor Dr. David Gerber is a liver transplant surgeon, clinician-scientist and long-time collaborator of Dr. Reid. |
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