Peer-reviewed Publications

Relevant Publications of Brian C. Cooley


Schlaff WD, Cooley BC, Shen W, Rock J, King T:  A rat uterine horn model of genital tract wound healing.  Fertility Sterility 48:866-872, 1987.

Stein BS, Cooley BC:  CO2 laser-assisted microscopic vasovasostomy. J Endourology 2:299-307, 1988.

Cooley BC, Ma L, Gould JS:  Rat femoral vein-to-vein grafts as a microvascular practice model:  Factors that influence patency. Microsurgery 12:43-45, 1991.

Cooley BC, Li XL, Dzwierzynski W, Gruel SM, Wright RR, Hall R, O'Brien EM, Fagan D, Hanel DP, Gould JS:  The de-endothelialized rat carotid arterial graft:  A versatile experimental model for the investigation of arterial thrombosis.  Thrombosis Research 67:1-14, 1992

Kulwicki KJ, Harris GF, Cooley BC:  A system for evaluation of surgical hand tremor.  Proc Ann Internat Conf IEEE Eng Med Biol Soc 15:977-978, 1993.

Ozbek MR, Brown DM, Deune EG, Lantieri LA, Kania NM, Pasia EN, Cooley BC, Wun T-C, Khouri RK:  Topical tissue factor pathway inhibitor improves free-flap survival in a model simulating free-flap errors.  J Reconstr Microsurg 11:185-188, 1995.

Cooley BC:  Heat-induced tissue fusion in microvascular anastomosis.  Microsurgery 17:198-208, 1996.

Cooley BC, Daley RA:  Free flap transplantation in mice. Microsurgery 18:320-323, 1998.

Cooley BC, Daley RA:  Murine microvascular anastomosis model of thrombosis. Thrombosis Res  96:157-159, 1999.

Khouri RK, Sherman R, Buncke HJ, Axel-Feller M, Hovius S, Benes CO, Ingram DM, Natarajan NN, Sherman JW, Yeramian PD, Cooley BC:  A Phase II trial of intraluminal irrigation with recombinant human tissue factor pathway inhibitor to prevent thrombosis in free flap surgery.  Plast Reconstr Surg 107:408-415, 2001.

Hsu PA, Cooley BC:  Effect of exercise on microsurgical hand tremor.  Microsurgery 23:323-327, 2003.

Cooley BC:  Murine model of neointimal formation and stenosis in vein grafts. Arterioscler Thromb Vasc Biol 24: 1180-1185, 2004.

Cooley BC, Chen C-Y, Friedman K, Datta YH:  A prothrombotic phenotype in the Copenhagen rat strain. Thrombosis Res 115:153-157, 2005.

Cooley BC:  A model of murine interpositional vein grafting.  Microsurgery 25:209-212, 2005.

Cooley BC, Daley RA, Toth JM:  Long-term BMP-2 induced bone formation in rat island and free flaps.  Microsurgery 25:167-173, 2005.

Cooley BC, Szema L, Chen CY, Schwab JP, Schmeling G:  A murine model of deep vein thrombosis: characterization and validation in transgenic mice.  Thrombosis and Haemostasis 94:498-503, 2005.

Rao R, Bagaria V, Cooley BC:  Posterolateral intertransverse lumbar fusion in a mouse model: surgical anatomy and operative technique. The Spine Journal 7:61-67, 2007.

Cooley BC, Chen CY, Schmeling G:  Increased venous versus arterial thrombosis in the Factor V Leiden mouse.  Thrombosis Res 119:747-751, 2007

Kusada A, Isogai N, Cooley BC: Electric injury model of murine arterial thrombosis.  Thrombosis Res 121:103-106, 2007.

Cooley BC:  Differential neointimal response in vein grafts and wire-injured arteries. Circ J 71:1649-1652, 2007.

Ionova IA, Vásquez-Vivar J, Whitsett J, Herrnreiter A, Medhora M, Cooley BC, Pieper GM:  Deficient BH4 production via de novo and salvage pathways regulates NO responses to cytokines in adult cardiac myocytes.  Am J Physiol Heart Circ Physiol 295:H2178-H2187, 2008.  PMCID:  PMC2614582

Rao R, Gourab K, Bagaria VB, Shidham VB, Metkar U, Cooley BC:  The effect of platelet rich plasma and bone marrow on murine posterolateral lumbar spine arthrodesis with bone morphogenetic protein.  J Bone Joint Surg [Am] 91:1199-1206, 2009.

Ionova IA, Vásquez-Vivar J, Cooley BC, Khanna AK, Whitsett J, Herrnreiter A, Migrino RQ, Ge J-D, Regner KR, Channon KM, Alp NJ, Pieper GM:  Cardiac myocyte-specific over-expression of human GTP cyclohydrolase I protects against acute cardiac allograft rejection.  Am J Physiol - Heart Circ 299:H88-H96, 2010.  PMCID:  PMC2904123

Pieper GM, Shah A, Harmann L, Cooley BC, Ionova IA, Migrino RQ:  Speckle-tracking 2-dimensional strain echocardiography:  A new noninvasive imaging tool to evaluate acute

rejection in cardiac transplantation.  J Heart Lung Transplant 29:1039-1046, 2010.

PMCID:  PMC2926230

Cooley BC: In vivo fluorescence imaging of large-vessel thrombosis in mice. Arterioscler Thromb Vasc Biol 31:1351-1356, 2011.  PMCID:  PMC3098306

Cooley BC:  Murine models of thrombosis.  Thrombos Res 129 Suppl 2:S62-S64, 2012.

Yassai M, Cooley B, Gorski J:  Developmental dynamics of post selection thymic iNKT
PLoS ONE 7:e43509, 2012.  PMCID:  PMC3425480

Cooley BC:  Collagen-induced thrombosis in murine arteries and veins.  Thrombos Res 131:49-54, 2013.

Cooley BC, Chen CY, Hess R, Schmeling G:  Incomplete resolution of deep vein thrombosis under reduced flow conditions.  Thrombos Res 131:55-58, 2013.

McDonald RA, White KM, Wu J, Cooley BC, Robertson KE, Halliday C, Lu R, Kennedy S, George SJ, Wan S, van Rooij E, Baker AH:  MiRNA-21 is dysregulated in response to vein grafting in mulitple models and genetic ablation in mice attenuates neointima formation.  Eur Heart J [in press]

Cooley BC, Herrera AJ:  Cross-modulatory effects of clopidogrel and heparin on platelet and fibrin incorporation in thrombosis.  Blood Coag Fibrinolysis [in press]

Aleman MM, Walton BL, Byrnes JR, Wang JG, Heisler MJ, Machlus KR, Cooley BC, Wolberg AS:  Elevated prothrombin promotes venous, but not arterial, thromdbosis in mice.  Arterioscler Thromb Vasc Biol [in press]

Shi G, Meister D, Daley RA, Cooley BC:  Thrombodynamics of microvascular repairs: effects of antithrombotic therapy on platelets and fibrin.  J Hand Surg [Am] [in press]



Relevant Publications of Mauricio Rojas


Vendrov AE, Madamanchi N, Hakim ZS, Rojas M, Runge MS. Thrombin and NAD (P) H Oxidase-<ediated Regulation of CD44 and BMP4-Id Pathway in VSMC, Restenosis, and Artherosclerosis. Circulation Research. 2006; 98:1254-1263.

DiMichele LD, Doherty JT, Rojas M, Mack CP, Beggs HE, Reichardt LF and Taylor JM. Cardiac-restricted FAK inactivation attenuates pressure-overload 
induced hypertrophy. Circulation Research. 2006

Liu P, Patil S., Rojas M, Fong A., Smyth S.S., and Patel D.D. CX3CR1 deficiency confers protection from intimal hyperplasia after arterial injury. ATVB. 2006; 26:2056-2062

Evangelista V, Pamuklar Z, Piccoli A, Manarini S, Dell'Elba G, Pecce R, Martelli N, Federico L, Rojas M, Berton G, Lowell CA, Totani L, and Smyth SS. Src family kinases mediate neutrophil adhesion to adherent platelets. Blood. 2007 Mar 15;109(6):2461-9.

Barrick C, Rojas M, Schoonhoven R, Smyth S, Threadgill DW. Cardiac response to pressure overload in 129S1/SvImJ and C57BL/6J mice: temporal and background dependent development of concentric left ventricular hypertrophy. Am J Physiology Heart Circ Physiol. 2006 Dec 15

Tatsuguchi M, Seok HY, Callis TE, Thomson JM, Chen JF, Newman M, Rojas M, Hammond SM, Wang DZ. Expression of microRNAs is dynamically regulated during cardiomyocyte hypertrophy. J Mol Cell Cardiol. 2007 Apr14.

Niu XL, Li J, Hakim ZS, Rojas M, Runge MS, Madamanchi NR. Lar deficiency enhances IGF-1 signaling in vascular smooth muscle cells and promotes neointima formation in response to vascular injury.  J Biol Chem. 2007 May 11

Stansfield WE & Rojas M (co-authors), Corn D, Willis M, Patterson C, Smyth SS, Selzman CH. Characterization of a Model to Independently Study Regression of Ventricular Hypertrophy. J Surg Res. 2007 Oct; 142(2): 387-93.

Vendrov AE, Hakim ZS, Madamanchi NR, Rojas M, Madamanchi C, and Runge MS. Atherosclerosis Is Attenuated by Limiting Superoxide Generation in Both Macrophages and Vessel Wall Cells. Arterioscler. Thromb. Vasc. Biol. 2007 Dec; 27(12): 2714-21.

Chen J, Murchison E, Tang R, Callis T, Tatsuguchi M, Deng Z, Rojas M, Hammond S, Schneider M, Selzman CH, Meissner G, Patterson C, Hannon G, Wang DZ. Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure. Proc Natl Acad Sci USA. 2008; 105: 2111-6.

Pandya K, Cowhig J, Brackhan J, Kim HS, Hagaman J, Rojas M, Carter Jr, Mao L, Rockman HA, Maeda N, Smithies O. Discordant on/off switching of gene expression in myocytes during cardiac hypertrophy in vivo.Proc Natl Acad Sci U S A. 2008 Aug 28.

Sayers RL, Sundberg-Smith LJ, Rojas M, Hayasaka H, Parsons JT, Mack CP, Taylor RL. FRNK expression promotes smooth muscle cell maturation during vascular development and after vascular injury. Arterioscler Throm Vasc Bio. 2008 Sep 11, 18787183

Hakim ZS, DiMichele LA, Rojas M, Mack CP, Taylor JM. FAK regulates cardiomyocyte survival following ischemia/reperfusion. J Mol Cell Cardiol. 2009 Feb; 46(2): 241-8. Dimichele LA, Hakim ZS, Sayers RL, Rojas M, Schwartz RJ, Mack CP, Taylor JM. Transient expression of FRNK reveals stage-specific requirement for focal adhesion kinase activity in cardiac growth. Circ Res. 2009, May 22; 104 (10): 1201-8

Barrack CJ, Roberts RB, Rojas M, Rajamannan NM, Suitt CB, O'Brien KD, Smyth SS, Threadgill DW. Reduced EGFR causes abnormal valvular differentiation leading to calcific aortic stenosis and left ventricular hypertrophy in C57BL/6J but not 129S1/SvImJ mice.

Am J Physiol Heart Circ Physiol. 2009 Jul; 297(1): 65-75 Willis MS, Rojas M, Li L, Selzman

CH, Tang RH, Stansfield WE, Rodriguez JE, Glass DJ, Patterson C.Muscle ring finger 1 mediates cardiac atrophy in vivo. Am J Physiol Heart Circ Physiol. 2009 Apr; 296(4): H997-H1006.

Stan field WE, Charles PC, Tang RH, Rojas M, Bhati R, Moss NC, Patterson C, Selzman CH. Regression of pressure-induced left ventricular hypertrophy is characterized by a distinct gene expression profile. J Thorac Cardiovasc Surg. 2009 Jan; 137(1): 232-8, 238e1-8

Niu XL, Madamanchi NR, Vendrov AE, Tchivilev I, Rojas M, Madamanchi C, Brandes RP, Krause KH, Humphries J, Smith A, Burnand KG, Range MS. Nox activator 1: a potential target for modulation of vascular reactive oxygen species in atherosclerotic arteries. Circulation. 2010 Feb 2; 121(4): 549-59. Epub 2010, Jan 18.

Antoniak S, Rojas M, Spring D, Bullard T, Verrier E, Bacall B, Mackman N, Pawlinski R. Protease-Activated Receptor 2 Deficiency Reduces Cardiac Ischemia/Reperfusion Injury. Arterioscler Thrombi Vass Biol. 2010, Aug 19.

Jerath MR, Liu P, Struthers M, Demetrio JA, Peng R, Peterson LB, Cumiskey AM, Yang L, Rojas M, Patel DD, Fong AM. Dual targeting of CCR2 and CX3CR1 in an arterial injury model of vascular inflammation. Thrombi J. 2010 Sep 13;8(1): 14

Gherghe CM, Duan J, Gong J, Rojas M, Klauber-Demore N, Majesky M, Deb A. Wnt1 is a proangiogenic molecule, enhances human endothelial progenitor function, and increases blood flow to ischemic limbs in a HGF- dependent manner. FASEB J. 2011 Feb 14