Procedures
The following procedures are available through the Core:
Preclincal Disease Models
| Vein Graft | To study pathogenesis of neointimal hyperplasis, a cause of vein graft failure |
| Carotid-Jugular Fistula | To study the mechanisms of neointimal lesion formation in the fistulas and evaluate both drug and gene therapies for this disease |
| Femoral Artery-Vein Fistula | To study the mechanisms of neointimal lesion formation in the fistulas and evaluate both drug and gene therapies for this disease |
| Renal Artery Stenosis | Surgical narrowing of the renal artery-relevant model of systemic hypertension |
| Aortic Banding | Surgical narrowing of the aortic arch to induce left ventricular pressure-volume overload |
| Reversible Aortic Banding | Surgical narrowing of the aorta with later removal of the band as a model of hypertrophy regression |
| Hind Limb Ischemia | Ligation of arteries in the hind limb to induce angiogenesis |
| Femoral Artery Injury | Removal of endothelium to study arterial neointimal formation after rheostasis |
| Carotid Artery Injury | Removal of endothelium to study arterial neointimal formation after rheostasis |
| Arterial and Venous Catheterization | Insertion of a ported catheter into an artery or vein to facilitate injection |
| Invasive Blood Pressure Measurement |
Direct measurement of intra-arterial pressures via inserted Scisense catheter |
| Thrombosis Model | Using ferric chloride applied to the carotid to study platelet function and thrombus formation |
| Indwelling Catheter Placement | Permanent placement of a ported catheter to allow for repeated intravenous or intra-arterial injections |
| Craniotomy (Pia Vessel Exposure) | Used as a model for vascular integrity or leakage |
| LAD Ligation | Ligation of the left anterior descending artery of the heart as a model of myocardial infarction |
| LAD Ischemia/Reperfusion | Ligation of the left anterior descending artery of the heart with reperfusion post ischemia |
| Pulmonary Artery Banding | Restricting pulmonary artery blood flow as a model for pulmonary hypertension |
| Ventricular Pressure-Volume Measurement | Direct measurement of cardiac left ventricle blood pressure and stroke volume (Scisense) |
| Telemetry Device Implantation | For acquisition of physiologic data from conscious, unrestrained animals over time |
| Renal Transplant | For immunobiological studies |
| Aortic Arch Transplant | Model for studies on morphology, imaging and mechanisms of arteriosclerosis |
| Banding or Ligation of Inferior Vena Cava | Experimental model of venous thrombosis |
| Splenectomy | Surgical removal of the spleen |
| Nephrectomy | Surgical removal of the kidney |
| Orchiectomy | Surgical removal of the testes, useful for studies involving hormonal influences on the cardiovascular system or tumors |
| Ovariectomy | Surgical removal of the ovaries, useful for studies involving hormonal influences on the cardiovascular system or tumors |
| Adrenalectomy | Surgical removal of the adrenal glands |
| Carotid Artery Ligation | Complete ligation of one of the carotid arteries |
| Cremaster Muscle Prep | Surgical incision and flattening of the thin cremaster muscle, useful for in situ blood flow studies (intravital microscopy) |
| Aortic Dissection | Post-mortem, microsurgical removal of the aorta from base of the heart to the abdominal bifurcation |
Cardiovascular Phenotyping
| Ultrasound |
Ultrasound assessment of organs, tumors or vasculature |
| 3-D Ultrasound | 3-D, volumetric assessment of tumors or organs |
| Ultrasound-guided Injection | Use of ultrasound to assure precise delivery of a substance to its intended target |
| Prenatal Ultrasound | Ultrasound imaging of fetuses |
| Prenatal Ultrasound with Fetal Harvest | Terminal procedure to assure matching of fetus with its ultrasound image |
| Whole Body Perfusion/Fixation | In situ perfusion of organs to be used for microscopy or tissue/cell culture |
| Tail-cuff Blood Pressure Measurements | Non-invasive measurement of blood pressure |
| Aortic Compliance | Non-invasive assessment of aortic elasticity using Doppler |
| Echocardiography | Functional assessment of the heart using ultrasound |
| Pulse-wave Doppler | Non-invasive assessment of blood flow through the arteries |
| Laser Doppler | Non-invasive assessment of blood flow using laser scanning technology. Useful for documenting change in blood flow patterns over time |
| Oxygen Saturation Measurement | Method of assessing cardiopulmonary function during surgical or non-surgical procedures |
| Minipump Implantation | For continuous infusion of investigational drugs |
