Research interests at Dittmer Lab
By current estimates, 25-35% of all human cancers are of viral origin or require viral infection as an essential cofactor. The goal of our research is to understand viral tumorigenesis, specifically, cancers that are caused by Kaposi’s sarcoma-associated herpesvirus (KSHV/HHV-8). KSHV is a double-stranded DNA virus of about 120kbp, which belongs to the rhadinovirus family of human herpesviruses. It was discovered in 1994 and is associated with Kaposi’s sarcoma (KS) as well as B-cell lymphoproliferative diseases such as pleural effusion lymphoma (PEL) and multicentric Castleman’s disease (MCD). These diseases are ultimately fatal as they affect internal organs and, in the U.S., are seen in the context of immune suppression such as HIV-positive individuals or transplant patients.
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