2008

Here are the publications of the Dittmer Lab from 2008 to 2012.

More on HIV-associated Kaposi’s sarcoma.
Krown SE, Lee JY, Dittmer DP; AIDS Malignancy Consortium.
N Engl J Med. 2008 Jan 31;358(5):535-6; author reply 536. doi: 10.1056/NEJMc072994. No abstract available.
PMID: 18234764

EBV microRNAs in primary lymphomas and targeting of CXCL-11 by ebv-mir-BHRF1-3.
Xia T, O’Hara A, Araujo I, Barreto J, Carvalho E, Sapucaia JB, Ramos JC, Luz E, Pedroso C, Manrique M, Toomey NL, Brites C, Dittmer DP, Harrington WJ Jr.
Cancer Res. 2008 Mar 1;68(5):1436-42. doi: 10.1158/0008-5472.CAN-07-5126.
PMID: 18316607

Multiple pathways for Epstein-Barr virus episome loss from nasopharyngeal carcinoma.
Dittmer DP, Hilscher CJ, Gulley ML, Yang EV, Chen M, Glaser R.
Int J Cancer. 2008 Nov 1;123(9):2105-12. doi: 10.1002/ijc.23685.
PMID: 18688856

Burkitt lymphoma in Brazil is characterized by geographically distinct clinicopathologic features.
Queiroga EM, Gualco G, Weiss LM, Dittmer DP, Araujo I, Klumb CE, Harrington WJ Jr, Bacchi CE.
Am J Clin Pathol. 2008 Dec;130(6):946-56. doi: 10.1309/AJCP64YOHAWLUMPK.
PMID: 19019773

2009

A review of human carcinogens–Part B: biological agents.
Bouvard V, Baan R, Straif K, Grosse Y, Secretan B, El Ghissassi F, Benbrahim-Tallaa L, Guha N, Freeman C, Galichet L, Cogliano V; WHO International Agency for Research on Cancer Monograph Working Group.
Lancet Oncol. 2009 Apr;10(4):321-2. No abstract available.
PMID: 19350698

Pre-micro RNA signatures delineate stages of endothelial cell transformation in Kaposi sarcoma.
O’Hara AJ, Chugh P, Wang L, Netto EM, Luz E, Harrington WJ, Dezube BJ, Damania B, Dittmer DP.
PLoS Pathog. 2009 Apr;5(4):e1000389. doi: 10.1371/journal.ppat.1000389. Epub 2009 Apr 17.
PMID: 19381257

Human herpesvirus replication and abnormal CD8+ T cell activation and low CD4+ T cell counts in antiretroviral-suppressed HIV-infected patients.
Jacobson MA, Ditmer DP, Sinclair E, Martin JN, Deeks SG, Hunt P, Mocarski ES, Shiboski C.
PLoS One. 2009;4(4):e5277. doi: 10.1371/journal.pone.0005277. Epub 2009 Apr 17.
PMID: 19381272

Tumor suppressor microRNAs are underrepresented in primary effusion lymphoma and Kaposi sarcoma.
O’Hara AJ, Wang L, Dezube BJ, Harrington WJ Jr, Damania B, Dittmer DP.
Blood. 2009 Jun 4;113(23):5938-41. doi: 10.1182/blood-2008-09-179168. Epub 2009 Feb 27.
PMID: 19252139

Toll-like receptor signaling controls reactivation of KSHV from latency.
Gregory SM, West JA, Dillon PJ, Hilscher C, Dittmer DP, Damania B.
Proc Natl Acad Sci U S A. 2009 Jul 14;106(28):11725-30. doi: 10.1073/pnas.0905316106. Epub 2009 Jun 29.
PMID: 19564611

Disruption of LANA in rhesus rhadinovirus generates a highly lytic recombinant virus.
Wen KW, Dittmer DP, Damania B.
J Virol. 2009 Oct;83(19):9786-802. doi: 10.1128/JVI.00704-09. Epub 2009 Jul 8.
PMID: 19587030

General and target-specific RNA binding properties of Epstein-Barr virus SM posttranscriptional regulatory protein.
Han Z, Verma D, Hilscher C, Dittmer DP, Swaminathan S.
J Virol. 2009 Nov;83(22):11635-44. doi: 10.1128/JVI.01483-09. Epub 2009 Sep 2.
PMID: 19726500

Maribavir inhibits epstein-barr virus transcription in addition to viral DNA replication.
Wang FZ, Roy D, Gershburg E, Whitehurst CB, Dittmer DP, Pagano JS.
J Virol. 2009 Dec;83(23):12108-17. doi: 10.1128/JVI.01575-09. Epub 2009 Sep 16.
PMID: 19759127

Molecular and clinical assessment in the treatment of AIDS Kaposi sarcoma with valproic Acid.
Lechowicz M, Dittmer DP, Lee JY, Krown SE, Wachsman W, Aboulafia D, Dezube BJ, Ratner L, Said J, Ambinder RF.
Clin Infect Dis. 2009 Dec 15;49(12):1946-9. doi: 10.1086/648447.
PMID: 19911999

KSHV latent genes and their regulation.
Dittmer DP.
In DNA Tumor Viruses. Springer, 2009. 495-520.

Analysis and QC for real-time QPCR arrays of human microRNAs.
Dittmer DP, Chugh P, Wang D, Borowiak M, Ziemiecki R, O’Hara A.
In MicroRNA Profiling in Cancer: A Bioinformatics Perspective (2009): 47-75.

2010

Distinct p53, p53:LANA, and LANA complexes in Kaposi’s Sarcoma–associated Herpesvirus Lymphomas.
Chen W, Hilton IB, Staudt MR, Burd CE, Dittmer DP.
J Virol. 2010 Apr;84(8):3898-908. doi: 10.1128/JVI.01321-09. Epub 2010 Feb 3.
PMID: 20130056

Dual inhibition of PI3K and mTOR inhibits autocrine and paracrine proliferative loops in PI3K/Akt/mTOR-addicted lymphomas.
Bhatt AP, Bhende PM, Sin SH, Roy D, Dittmer DP, Damania B.
Blood. 2010 Jun 3;115(22):4455-63. doi: 10.1182/blood-2009-10-251082. Epub 2010 Mar 18.
PMID: 20299510

Efficiency clustering for low-density microarrays and its application to QPCR.
Lock EF, Ziemiecke R, Marron J, Dittmer DP.
BMC Bioinformatics. 2010 Jul 20;11:386. doi: 10.1186/1471-2105-11-386.
PMID: 20646303

An appraisal of non-AIDS-defining cancers: comment on “Spectrum of cancer risk late after AIDS onset in the United States”.
Dittmer DP.
Arch Intern Med. 2010 Aug 9;170(15):1345-6. doi: 10.1001/archinternmed.2010.250. No abstract available.
PMID: 20696959

Genome-wide real-time PCR for West Nile virus reduces the false-negative rate and facilitates new strain discovery.
Papin JF, Vahrson W, Larson L, Dittmer DP.
J Virol Methods. 2010 Oct;169(1):103-11. doi: 10.1016/j.jviromet.2010.07.005. Epub 2010 Jul 14.
PMID: 20637239

The viral latency-associated nuclear antigen augments the B-cell response to antigen in vivo.
Sin SH, Fakhari FD, Dittmer DP.
J Virol. 2010 Oct;84(20):10653-60. doi: 10.1128/JVI.00848-10. Epub 2010 Aug 4.
PMID: 20686032

Profiling of pre-micro RNAs and microRNAs using quantitative real-time PCR (qPCR) arrays.
Chugh P, Tamburro K, Dittmer DP.
J Vis Exp. 2010 Dec 3;(46). pii: 2210. doi: 10.3791/2210.
PMID: 21178961

HHV8-encoded and HHV8-regulated microRNAs.
Chugh P, Dittmer DP.
In Kaposi Sarcoma: A Model of Oncogenesis (ed. L Pantanowitz, J Stebbing, BJ Dezube). Research Signpost, 2010. 75-83.

2011

Pilot study of oral valganciclovir therapy in patients with classic Kaposi sarcoma.
Krown SE, Dittmer DP, Cesarman E.
J Infect Dis. 2011 Apr 15;203(8):1082-6. doi: 10.1093/infdis/jiq177.
PMID: 21450998

Overview of the oral HIV/AIDS Research Alliance Program.
Shiboski CH, Webster-Cyriaque JY, Ghannoum M, Greenspan JS, Dittmer D; Oral HIV/AIDS Research Alliance, Subcommittee of the AIDS Clinical Trial Group.
Adv Dent Res. 2011 Apr;23(1):28-33. doi: 10.1177/0022034511399084. Review.
PMID: 21441477

Tumor suppressor genes FHIT and WWOX are deleted in primary effusion lymphoma (PEL) cell lines.
Roy D, Sin SH, Damania B, Dittmer DP.
Blood. 2011 Aug 18;118(7):e32-9. doi: 10.1182/blood-2010-12-323659. Epub 2011 Jun 17.
PMID: 21685375

Ribosomal protein S6 interacts with the latency-associated nuclear antigen of Kaposi’s sarcoma-associated herpesvirus.
Chen W, Dittmer DP.
J Virol. 2011 Sep;85(18):9495-505. doi: 10.1128/JVI.02620-10. Epub 2011 Jul 6.
PMID: 21734034

Phosphatase and tensin homolog on chromosome 10 is phosphorylated in primary effusion lymphoma and Kaposi’s sarcoma.
Roy D, Dittmer DP.
Am J Pathol. 2011 Oct;179(4):2108-19. doi: 10.1016/j.ajpath.2011.06.017. Epub 2011 Aug 3.
PMID: 21819957

Restricted Kaposi’s sarcoma (KS) herpesvirus transcription in KS lesions from patients on successful antiretroviral therapy.
Dittmer DP.
MBio. 2011 Nov 1;2(6):e00138-11. doi: 10.1128/mBio.00138-11. Print 2011.
PMID: 22045987

2012

Cytokine homologs of human gammaherpesviruses.
Sin SH, Dittmer DP.
J Interferon Cytokine Res. 2012 Feb;32(2):53-9. doi: 10.1089/jir.2011.0083. Epub 2011 Dec 5. Review.
PMID: 22142220

Rapalogs in viral cancers.
Dittmer DP, Bhatt AP, Damania B.
Expert Opin Investig Drugs. 2012 Feb;21(2):135-8. doi: 10.1517/13543784.2012.642369. Epub 2012 Jan 4.
PMID: 22214523

Treatment of Kaposi sarcoma-associated herpesvirus-associated cancers.
Dittmer DP, Richards KL, Damania B.
Front Microbiol. 2012 Apr 18;3:141. doi: 10.3389/fmicb.2012.00141. eCollection 2012.
PMID: 22529843

Latent Kaposi’s sarcoma-associated herpesvirus infection of monocytes downregulates expression of adaptive immune response costimulatory receptors and proinflammatory cytokines.
Gregory SM, Wang L, West JA, Dittmer DP, Damania B.
J Virol. 2012 Apr;86(7):3916-23. doi: 10.1128/JVI.06437-11. Epub 2012 Jan 25.
PMID: 22278234

Rapamycin with antiretroviral therapy in AIDS-associated Kaposi sarcoma: an AIDS Malignancy Consortium study.
Krown SE, Roy D, Lee JY, Dezube BJ, Reid EG, Venkataramanan R, Han K, Cesarman E, Dittmer DP.
J Acquir Immune Defic Syndr. 2012 Apr 15;59(5):447-54. doi: 10.1097/QAI.0b013e31823e7884.
PMID: 22067664

Dysregulation of fatty acid synthesis and glycolysis in non-Hodgkin lymphoma.
Bhatt AP, Jacobs SR, Freemerman AJ, Makowski L, Rathmell JC, Dittmer DP, Damania B.
Proc Natl Acad Sci U S A. 2012 Jul 17; 109(29):11818-23. doi: 10.1073/pnas.1205995109. Epub 2012 Jun 29.
PMID: 22752304

Vironome of Kaposi sarcoma associated herpesvirus-inflammatory cytokine syndrome in an AIDS patient reveals co-infection of human herpesvirus 8 and human herpesvirus 6A.
Tamburro KM, Yang D, Poisson J, Fedoriw Y, Roy D, Lucas A, Sin SH, Malouf N, Moylan V, Damania B, Moll S, van der Horst C, Dittmer DP.
Virology. 2012 Nov 10;433(1):220-5. doi: 10.1016/j.virol.2012.08.014. Epub 2012 Aug 24.
PMID: 22925337

Hsp90 inhibitors are efficacious against Kaposi Sarcoma by enhancing the degradation of the essential viral gene LANA, of the viral co-receptor EphA2 as well as other client proteins.
Chen W, Sin SH, Wen KW, Damania B, Dittmer DP.
PLoS Pathog. 2012;8(11):e1003048. doi: 10.1371/journal.ppat.1003048. Epub 2012 Nov 29.
PMID:23209418

Quantitative analysis of the bidirectional viral G-protein-coupled receptor and lytic latency-associated nuclear antigen promoter of Kaposi’s sarcoma-associated herpesvirus.
Hilton IB, Dittmer DP.
J Virol. 2012 Sep; 86(18):9683-95. doi: 10.1128/JVI.00881-12. Epub 2012 Jun 27.
PMID: 22740392

Potential pitfalls in microRNA profiling.
Chugh P, Dittmer DP.
Wiley Interdiscip Rev RNA. 2012 Sep-Oct;3(5):601-16. doi: 10.1002/wrna.1120. Epub 2012 May 7. Review.
PMID: 22566380