2010s

Publications from the 2010s

Distinct p53, p53:LANA, and LANA complexes in Kaposi's Sarcoma--associated Herpesvirus Lymphomas.
Chen W, Hilton IB, Staudt MR, Burd CE, Dittmer DP.
J Virol. 2010 Apr;84(8):3898-908. doi: 10.1128/JVI.01321-09. Epub 2010 Feb 3.
PMID: 20130056

Dual inhibition of PI3K and mTOR inhibits autocrine and paracrine proliferative loops in PI3K/Akt/mTOR-addicted lymphomas.
Bhatt AP, Bhende PM, Sin SH, Roy D, Dittmer DP, Damania B.
Blood. 2010 Jun 3;115(22):4455-63. doi: 10.1182/blood-2009-10-251082. Epub 2010 Mar 18.
PMID: 20299510

Efficiency clustering for low-density microarrays and its application to QPCR.
Lock EF, Ziemiecke R, Marron J, Dittmer DP.
BMC Bioinformatics. 2010 Jul 20;11:386. doi: 10.1186/1471-2105-11-386.
PMID: 20646303

An appraisal of non-AIDS-defining cancers: comment on "Spectrum of cancer risk late after AIDS onset in the United States".
Dittmer DP.
Arch Intern Med. 2010 Aug 9;170(15):1345-6. doi: 10.1001/archinternmed.2010.250. No abstract available.
PMID: 20696959

Genome-wide real-time PCR for West Nile virus reduces the false-negative rate and facilitates new strain discovery.
Papin JF, Vahrson W, Larson L, Dittmer DP.
J Virol Methods. 2010 Oct;169(1):103-11. doi: 10.1016/j.jviromet.2010.07.005. Epub 2010 Jul 14.
PMID: 20637239

The viral latency-associated nuclear antigen augments the B-cell response to antigen in vivo.
Sin SH, Fakhari FD, Dittmer DP.
J Virol. 2010 Oct;84(20):10653-60. doi: 10.1128/JVI.00848-10. Epub 2010 Aug 4.
PMID: 20686032

Profiling of pre-micro RNAs and microRNAs using quantitative real-time PCR (qPCR) arrays.
Chugh P, Tamburro K, Dittmer DP.
J Vis Exp. 2010 Dec 3;(46). pii: 2210. doi: 10.3791/2210.
PMID: 21178961

HHV8-encoded and HHV8-regulated microRNAs.
Chugh P, Dittmer DP.
In Kaposi Sarcoma: A Model of Oncogenesis (ed. L Pantanowitz, J Stebbing, BJ Dezube).  Research Signpost, 2010.  75-83.

Pilot study of oral valganciclovir therapy in patients with classic Kaposi sarcoma.
Krown SE, Dittmer DP, Cesarman E.
J Infect Dis. 2011 Apr 15;203(8):1082-6. doi: 10.1093/infdis/jiq177.
PMID: 21450998

Overview of the oral HIV/AIDS Research Alliance Program.
Shiboski CH, Webster-Cyriaque JY, Ghannoum M, Greenspan JS, Dittmer D; Oral HIV/AIDS Research Alliance, Subcommittee of the AIDS Clinical Trial Group.
Adv Dent Res. 2011 Apr;23(1):28-33. doi: 10.1177/0022034511399084. Review.
PMID: 21441477

Tumor suppressor genes FHIT and WWOX are deleted in primary effusion lymphoma (PEL) cell lines.
Roy D, Sin SH, Damania B, Dittmer DP.
Blood. 2011 Aug 18;118(7):e32-9. doi: 10.1182/blood-2010-12-323659. Epub 2011 Jun 17.
PMID: 21685375

Ribosomal protein S6 interacts with the latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus.
Chen W, Dittmer DP.
J Virol. 2011 Sep;85(18):9495-505. doi: 10.1128/JVI.02620-10. Epub 2011 Jul 6.
PMID: 21734034

Phosphatase and tensin homolog on chromosome 10 is phosphorylated in primary effusion lymphoma and Kaposi's sarcoma.
Roy D, Dittmer DP.
Am J Pathol. 2011 Oct;179(4):2108-19. doi: 10.1016/j.ajpath.2011.06.017. Epub 2011 Aug 3.
PMID: 21819957

Restricted Kaposi's sarcoma (KS) herpesvirus transcription in KS lesions from patients on successful antiretroviral therapy.
Dittmer DP.
MBio. 2011 Nov 1;2(6):e00138-11. doi: 10.1128/mBio.00138-11. Print 2011.
PMID: 22045987

Zidovudine-based lytic-inducing chemotherapy for Epstein-Barr virus-related lymphomas.
Bayraktar UD, Diaz LA, Ashlock B, Toomey N, Cabral L, Bayraktar S, Pereira D, Dittmer DP, Ramos JC.
Leuk Lymphoma. 2014 Apr;55(4):786-94. doi: 10.3109/10428194.2013.818142. Epub 2013 Aug 28.
PMID: 23837493

Vironome of Kaposi sarcoma associated herpesvirus-inflammatory cytokine syndrome in an AIDS patient reveals co-infection of human herpesvirus 8 and human herpesvirus 6A.
Tamburro KM, Yang D, Poisson J, Fedoriw Y, Roy D, Lucas A, Sin SH, Malouf N, Moylan V, Damania B, Moll S, van der Horst C, Dittmer DP.
Virology. 2012 Nov 10;433(1):220-5. doi: 10.1016/j.virol.2012.08.014. Epub 2012 Aug 24.
PMID: 22925337

Hsp90 inhibitors are efficacious against Kaposi Sarcoma by enhancing the degradation of the essential viral gene LANA, of the viral co-receptor EphA2 as well as other client proteins.
Chen W, Sin SH, Wen KW, Damania B, Dittmer DP.
PLoS Pathog. 2012;8(11):e1003048. doi: 10.1371/journal.ppat.1003048. Epub 2012 Nov 29.
PMID: 23209418

mTOR inhibitors block Kaposi sarcoma growth by inhibiting essential autocrine growth factors and tumor angiogenesis.
Roy D, Sin SH, Lucas A, Venkataramanan R, Wang L, Eason A, Chavakula V, Hilton IB, Tamburro KM, Damania B, Dittmer DP.
Cancer Res. 2013 Apr 1;73(7):2235-46. doi: 10.1158/0008-5472.CAN-12-1851. Epub 2013 Feb 4.
PMID: 23382046

Incidence and timing of cancer in HIV-infected individuals following initiation of combination antiretroviral therapy.
Yanik EL, Napravnik S, Cole SR, Achenbach CJ, Gopal S, Olshan A, Dittmer DP, Kitahata MM, Mugavero MJ, Saag M, Moore RD, Mayer K, Mathews WC, Hunt PW, Rodriguez B, Eron JJ.
Clin Infect Dis. 2013 Sep;57(5):756-64. doi: 10.1093/cid/cit369. Epub 2013 Jun 4.
PMID: 23735330

Moving forward in HIV-associated cancer.
Gopal S, Achenbach CJ, Yanik EL, Dittmer DP, Eron JJ, Engels EA.
J Clin Oncol. 2014 Mar 20;32(9):876-80. doi: 10.1200/JCO.2013.53.1376. Epub 2014 Feb 18. No abstract available.
PMID: 24550416

Relationship of immunologic response to antiretroviral therapy with non-AIDS defining cancer incidence.
Yanik EL, Napravnik S, Cole SR, Achenbach CJ, Gopal S, Dittmer DP, Olshan AF, Kitahata MM, Mugavero MJ, Saag M, Moore RD, Mathews WC, Hunt P, Eron JJ.
AIDS. 2014 Apr 24;28(7):979-87. doi: 10.1097/QAD.0000000000000167.
PMID: 24681415