Research Assistant Professor
605 Mary Ellen Jones, CB #7290
My research interests are focused on the interactions between T lymphocytes, a crucial arm of the immune system, and other arms of the immune system and ways that we can use these interactions to modulate the resultant T cell responses in a clinically useful way. I have studied this in the context of autoimmune process, graft transplantation and during trauma. My current interests involve i) the role of regulatory CD8lo T cells produced in vivo after incomplete antigen stimulation and ii) the role of homeostatic proliferation and apoptosis of T cells in causing a perturbed immune system in models of burn injury.
Neely CJ, Maile R, Wang MJ, Vadlamudi S, Meyer AA, Cairns BA (2011). Th17 (IFNγ- IL17+) CD4+ T cells generated after burn injury may be a novel cellular mechanism for postburn immunosuppression. J Trauma. 70(3):681-90.
Cairns BA, Barnes CM, Mlot S, Meyer AA, Maile R (2008). Toll-like receptor 2 and 4 ligation results in complex altered cytokine profiles early and late after burn injury. J Trauma. 64(4):1069-77.
Moore CB, Medina MA, van Deventer HW, O'Connor BP, Cameron S, Taxman DJ, Maile R, Ting JP, Cairns BA (2007). Downregulation of immune signaling genes in patients with large surface burn injury. J Burn Care Res. 28(6):879-87.
Tian S, Maile R, Collins EJ, Frelinger JA (2007). CD8+ T cell activation is governed by TCR-peptide/MHC affinity, not dissociation rate. J Immunol. 179(5):2952-60.
Buchanan IB, Maile R, Frelinger JA, Fair JH, Meyer AA, Cairns BA (2006). The effect of burn injury on CD8+ and CD4+ T cells in an irradiation model of homeostatic proliferation. J Trauma. 61(5):1062-8.
Cairns B, Maile R, Barnes CM, Frelinger JA, Meyer AA (2006). Increased Toll-like receptor 4 expression on T cells may be a mechanism for enhanced T cell response late after burn injury. J Trauma. 61(2):293-8.
Maile R, Barnes CM, Nielsen AI, Meyer AA, Frelinger JA, Cairns BA (2006). Lymphopenia-induced homeostatic proliferation of CD8+ T cells is a mechanism for effective allogeneic skin graft rejection following burn injury. J Immunol. 176(11):6717-26.
Maile R, Pop SM, Tisch R, Collins EJ, Cairns BA, Frelinger JA (2006). Low-avidity CD8lo T cells induced by incomplete antigen stimulation in vivo regulate naive higher avidity CD8hi T cell responses to the same antigen. Eur J Immunol. 36(2):397-410.
Maile R, Siler CA, Kerry SE, Midkiff KE, Collins EJ, Frelinger JA (2005). Peripheral "CD8 tuning" dynamically modulates the size and responsiveness of an antigen-specific T cell pool in vivo. J Immunol. 174(2):619-27.
Kerry SE, Maile R, Collins EJ, Frelinger JA (2005). Memory CD8 T cells require CD8 coreceptor engagement for calcium mobilization and proliferation, but not cytokine production. Immunology. 114(1):44-52.
Federation of Immunology Clinical Societies Travel Award (2005)
University of North Carolina at Chapel Hill Postdoctoral Award for Research Excellence (2004)
British Society for Immunology Travel Award (2003)
Wellcome Trust Studentship (1997-98)
Knowlson Trust Studentship (1995-98)