Department of Medicine
3330 Thurston-Bowles, CB #7280
Leukocyte migration to the joint is a critical step in the disease pathogenesis of rheumatoid arthritis (RA). Autoreactive inflammatory cells leave the circulation and are honed to their immunologic target through a process called chemotaxis. One of my research interests focuses on the regulation of chemokine receptors (in particular CX3CR1 and CXCR4) and downstream G-protein coupled receptor kinases (GRKs) as they pertain to leukocyte migration and the development of immune-mediated diseases.
The CXCR4 chemokine receptor and its ligand CXCL12 (SDF-1) play a critical role in homeostatic leukocyte migration and development, and have been implicated in numerous immune-mediated disease processes such as cancer, HIV, rheumatoid arthritis, and immunodeficiency. Chemokine receptors are G protein coupled receptors (GPCRs) and regulated by GRKs. My lab has particular focus on the selective regulatory role of GRK3 on the CXCL12/CXCR4 signaling axis as it pertains to RA, breast cancer, and bone marrow signaling interactions.
Rampersad RR, Esserman D, McGinnis MW, Lee DM, Patel DD, and Tarrant TK. S100A9 is not essential for disease expression in an acute (K/BxN) or chronic (CIA) model of inflammatory arthritis. Scan J Rheumatol 2009; 38(6):445-9.
Kim JS, An H, Rieter BJ, Sartor B, Lin W, Lin W*, Tarrant TK*. Multimodal optical and Gd-based nanoparticles for imaging in inflammatory arthritis. Clin Exp Rheumatol 2009; 27: 580-586. *Co- corresponding authors.
Jerath MR, Kwan M, Kannarkat M, Mirakhur B, Carey L, Platts-Mills TAE, and Tarrant TK. A desensitization protocol for the monoclonal antibody, cetuximab. J Aller Clin Immunol 2009;123(1):260-2.
Tarrant TK, Rampersad RR, Esserman D, Rothlein LR, Liu P, Lefkowitz RM, Lee DM, and Patel DD. Granulocyte chemotaxis and disease expression are differentially regulated by GRK subtype in an acute inflammatory arthritis model (K/BxN). Clin Immunol 2008;129(1):115-22.
Graziewicz M, Tarrant TK, Buckley B, Roberts J, Fulton L, Hansen H, Ørum H, Kole R, and Sazani P. An Endogenous TNF-alpha Antagonist Induced by Splice Switching Oligonucleotides Reduces Inflammation in Arthritis and Hepatitis Mouse Models. Molecular Therapy 2008;16(7):1316-22.
Rieter BJ, Kim JS, Taylor KML., An H, Lin W, Tarrant T, and Lin W. Hybrid Silica Nanoparticles for Multimodal Imaging. Angew. Chem 2007; 46: 1-4.
Xu H, Silver PB, Tarrant TK, Chan CC, and Caspi RR. TGF-beta inhibits activation and uveitogenicity of primary but not of fully polarized retinal antigen-specific memory/ effector T cells. Invest Ophthalmol Vis Sci 2003; 44: 4805-12.
Tarrant TK, Frazer DH, Aya-Ay JP, and Patel DD. B cell loss leading to remission in severe systemic lupus erythematosus. J Rheum 2003; 30: 412-4.
Silver PB, Tarrant TK, Chan CC, Wiggert B, and Caspi RR. Mice deficient in inducible nitric oxide synthase are fully susceptible to experimental autoimmune uveoretinitis. Invest Ophthalmol Vis Sci 1999; 40: 1280-1284.
Tarrant TK, Silver PB, Rizzo LV, Chan CC, Wiggert B, and Caspi RR. Interleukin-12 protects from a Th1-mediated autoimmune disease, experimental autoimmune uveitis, through a mechanism involving IFN-gamma and NO. J Exp Med 1999; 189: 219-230.
Tarrant TK, Silver PB, Chan CC, Wiggert B, Magram J, and Caspi RR. Endogenous IL-12 is required for induction and expression of experimental autoimmune uveitis. J Immunol 1998; 161: 122-127.
Pendergrast RA, Iliff CE, Coskuncan NM, Caspi RR, Sartini G, Tarrant TK, Lutty GA, and McLeod DS. T cell traffic and the inflammatory response in experimental autoimmune uveoretinitis. Invest Ophthalmol Vis Sci 1998; 39: 754-762.
Jones LS, Rizzo LV, Agarwal RK, Tarrant TK, Chan CC, Wiggert B, and Caspi RR. IFN-gamma-deficient mice develop experimental autoimmune uveitis in the context of a deviant effector response. J Immunol 1997; 158: 5997-6005.